Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu–Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer

Kaynar, Hasan; Meral, Mehmet; Turhan, Hamdullah; Keleş, Mustafa; Çelik, Gülnaz; Akçay, Fatih

doi:10.1016/j.canlet.2004.12.005

Cited by 113 publications

(90 citation statements)

References 34 publications

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“…In a recent case-control study, erythrocyte CuZn SOD and catalase activities were significantly increased in subjects with NSCLC compared with healthy controls, while GPx activity was only numerically higher in NSCLC subjects [17]. However, the apparently discrepant results from the present study could be related to lack of measurement of Mn SOD and ethnic differences in functional polymorphisms of antioxidant genes [18,19].…”

Section: Discussioncontrasting

confidence: 89%

Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

Chan‐Yeung²,

Ho³

et al. 2006

European Respiratory Journal

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The present study aimed to determine the alterations of antioxidant activities in erythrocytes from patients with nonsmall cell lung carcinoma (NSCLC).A comparative study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects was conducted. The antioxidants catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured using chemical kinetic reactions under spectrophotometry.In total, 189 cases of mostly advanced-stage IIIB or stage IV NSCLC and 202 healthy controls were studied. In subjects with lung cancer, there was similar catalase activity, lower SOD activity (median (interquartile range) 13.4 (9.0-27.2) versus 48. ) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, sex, smoking status, or tumour cell types. However, more advanced disease (stage IV compared with stage IIIB) was associated with lower SOD activity. Using multivariable analysis, the presence of lung cancer independently predicted SOD and GPx activities.In conclusion, nonsmall cell lung carcinoma in Chinese subjects is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis.

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Section: Discussioncontrasting

confidence: 89%

Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

Chan‐Yeung²,

Ho³

et al. 2006

European Respiratory Journal

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“…Kaynar et al studied the activities of antioxidant enzymes and demonstrated that erythrocyte malondialdehyde, nitric oxide, total glutathione levels and erythrocyte superoxide dismutase, catalase and xanthine oxidase activities were significantly higher in patients with LC than in controls. This study indicates significant changes in antioxidant defense system in LC patients, which may lead to enhanced action of oxygen radicals, resulting in lipid peroxidation [29]. One of the lipid peroxidation end products, malondialdehyde level in patients with LC has been found significantly higher than those in controls [30].…”

Section: Discussionmentioning

confidence: 64%

Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

et al. 2007

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“…Measurement of GSH-Px activity was based on the method described by Kaynar et al (13). The whole activity of GSH-Px was evaluated using the oxidation of glutathione (GSH) reacted with cumene hydroperoxide.…”

Section: Activity Detection Of Serum Superoxide Dismutase (Sod) and Gmentioning

confidence: 99%

Aged black garlic extract induces inhibition of gastric cancer cell growth inï¿½vitro and inï¿½vivo

et al. 2011

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Abstract. There is mounting evidence that garlic extracts possess significant anticancer actions. However, no studies have been reported on the effects of aged black garlic extracts (ABGE) on gastric cancer in vitro or in vivo. To examine the potential action of ABGE against gastric cancer, the present study evaluated its effect on the inhibition of cell proliferation and induction of apoptosis in SGC-7901 human gastric cancer cells. Additionally, we performed an in vivo study by inoculating the murine foregastric carcinoma cell line in Kunming mice and treating them with various doses of ABGE (0, 200, 400 and 800 mg/kg, intraperitoneally) for 2 weeks. Dosedependent apoptosis was detected in ABGE-treated cells in in vitro studies. In tumor-bearing mice, significant antitumor effects of ABGE were observed, such as growth inhibition of inoculated tumors. Further investigation of serum superoxide dismutases, glutathione peroxidase, interleukin-2 and the increased indices of spleen and thymus indicated that the anticancer action of ABGE may be partly due to its antioxidant and immuno modulative effects.

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Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu–Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer

Cited by 113 publications

References 34 publications

Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

Disturbance of systemic antioxidant profile in nonsmall cell lung carcinoma

Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Aged black garlic extract induces inhibition of gastric cancer cell growth inï¿½vitro and inï¿½vivo

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