Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Elkıran, Emin Tamer; Mar, Nefsal; Aygen, Bilge; Gürsu, Ferit; Karaoğlu, Aziz; Koca, Süleyman Serdar

doi:10.1186/1471-2407-7-48

Cited by 105 publications

(94 citation statements)

References 37 publications

(28 reference statements)

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“…Paraoxonase (PON-1) and arylesterase (ARE) are esterase enzymes with antioxidant properties in a complementary structure. PON-1 shows a structure that binds to high-density lipoprotein (HDL) and protects low-density lipoprotein (LDL) and HDL from oxidative stress by contributing to the destruction of organophosphorus compounds, such as paraoxone and lipid peroxidation products (11). In humans, PON-1 has been shown to play a role in the pathophysiology of many diseases (23).…”

Section: Praca Oryginalnamentioning

confidence: 99%

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Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Gültekin

Ural

Paşa

et al. 2017

Medycyna Weterynaryjna

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SummaryVector-borne diseases in dogs are a major health problem of zoonotic importance. Canine monocytic ehrlichiosis (CME) is one of the most common vector-borne infections in dogs. Co-infections with vectorborne diseases are reported to cause more severe pathological effects than mono-infections. The current study investigates the effects of mono-and co-infections with CME on oxidative status and lipid profiles in dogs. Dogs with vector-borne diseases were divided into two groups, mono-infected (n = 22) and co-infected (n = 23) with CME, and compared to a healthy group (n = 20). Double and triple co-infections with other vector-borne diseases included A. phagocytophilum, L. infantum, and D. immitis. The serum lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglycerides) and the total and individual markers of oxidative status (total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), paraoxonase (PON-1), and arylesterase (ARE)) were evaluated. Significant decreases in PON-1 and ARE enzyme activities and HDL concentration, as well as increases in TOS level, MDA, LDL, and triglyceride concentrations were determined in both mono-and co-infected groups compared to the healthy control group. No significant differences between the groups were found in the TAC level or cholesterol concentration. In conclusion, alterations in lipid profile and increase in oxidative stress were observed in dogs with CME compared to the healthy control group, however, no significant differences were detected between mono-and co-infected dogs.

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Section: Praca Oryginalnamentioning

confidence: 99%

“…The enzymes PON-1 and ARE are part of an antioxidant system that protects HDL and LDL particles from oxidation (11,23). The significantly decreased activity of PON-1 has been demonstrated in dogs diagnosed with leishmaniosis, babesiosis, parvoviral enteritis, and acute pancreatitis (17,24,31,39).…”

Section: Co-infected (N = 23)mentioning

confidence: 99%

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Gültekin

Ural

Paşa

et al. 2017

Medycyna Weterynaryjna

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“…18 In recent years, number of the studies investigating the relation between PON1 activity and cancer are increasing. Compared to the healthy controls, lower serum levels of PON1 were measured in patients suffering from breast 19,20 , lung 20,21 , laryngeal 22 , gastric 23 , pancreatic 24 and colorectal cancer. 20 Variations due to the presence of single nucleotide polymorphisms in antioxidant enzymes may contribute to the inter-individual differences between the transcript levels and enzyme activities, which might play a significant role in the development of cancer.…”

Section: Introductionmentioning

confidence: 99%

Association Between PON1 L55M Polymorphism and PON1 Enzyme Activity in Patients with Leukemia.

Eras¹,

Tombak²,

Yalın³

et al. 2017

UHOD

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Paraoxonase 1 (PON1) is an important antioxidant enzyme which has a role in preventing the effects of systemic oxidative stress. The purpose of our study was to investigate the possible association between PON1 L55M polymorphism and leukemia development and to determine the relationship between PON1 genotypes and PON1 enzyme activities. Genotypes of 102 cases and 112 healthy controls were determined by PCR-RFLP. PON1 enzyme activity was determined according to Eckerson's method. The ratio of MM genotype belonging to PON1 L55M polymorphism in control group was 6.3% and was 7.8% in patients with leukemia (p= 0.39). PON1 enzyme activity was 118.8 ± 115.1 U/mL in control group, while decreased to 75.6 ± 64.4 U/mL in patients with leukemia (p= 0.004). PON1 enzyme activities of the individuals with MM genotypes belonging to PON1 L55M polymorphism was 57.43 ± 21.61 U/ mL in control group and decreased to 39.18 ± 45.61 U/mL in leukemic patients. Our results suggest that, PON1 L55M polymorphism genotype ratios do not affect leukemia development. However, reduced PON1 enzyme activity and also the combination of PON1 L55M polymorphism with reduced PON1 enzyme activity are associated with the increased risk of leukemia. Furthermore, older age may be a risk factor for developing leukemia. PON1 enzim aktivitesi Eckerson yöntemi ile ölçüldü. PON1 L55M polimorfizmine ait MM genotip oranları kontrol grubunda %6.3 iken lösemili hastalarda % 7.8 idi (p= 0.39). PON1 enzim aktivitesi kontrol grubunda 118.8 ± 115.1 U/mL iken lösemili hastalarda düşük olarak saptandı (75.6 ± 64.4 U/mL, p= 0.004). PON1 L55M polimorfizmine ait MM genotipli bireylerin PON1 enzim aktivitesi kontrol grubunda 57.43 ± 21.61 U/mL iken lösemili hastalarda düşük olarak saptandı (39.18 ± 45.61 U/mL). Bizim bulgularımız PON1 L55M polimorfizmi genotip oranlarının lösemi gelişimini etkilemediğini göstermektedir. Bununla birlikte, düşük PON1 enzim aktivitesi tek başına ve PON1 L55M polimorfizmi ile birlikte lösemi riski artışı ile ilişkilidir. Ayrıca ileri yaş lösemiye yakalanma olasılığını yükseltir.

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“…A atividade enzimática da PON1 ainda exibe uma variação entre os indivíduos de diferentes etnias, de aproximadamente 10 a 40 vezes (Cataño et al, 2006;Elkiran et al, 2007;Eng et al, 2009;Eom et al, 2011).…”

Section: Pon1 E Hdlunclassified

“…Alterações na circulação dos níveis de PON1 podem também ser encontradas numa variedade de doenças que envolvem o estresse oxidativo, incluindo doença cardiovascular (Mackness et al, 2004;Gupta et al, 2011), diabetes (Iborra, 2006;Flekac et al, 2008), cânceres (Stevens et al, 2006;Elkiran et al, 2007;Camuzcuoglu et al, 2009), ou até mesmo entre indivíduos saudáveis (Ferreira, 2007;Parra et al, 2010;Singh et al, 2011).…”

Section: Pon1 E Hdlunclassified

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

Macedo¹

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Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population

Cited by 105 publications

References 37 publications

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

Association Between PON1 L55M Polymorphism and PON1 Enzyme Activity in Patients with Leukemia.

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

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