Glutathione—a review on its role and significance in Parkinson's disease

Martin, Heather L.; Teismann, Peter

doi:10.1096/fj.08-125443

Cited by 268 publications

(189 citation statements)

References 92 publications

Supporting

Mentioning

179

Contrasting

Unclassified

Order By: Relevance

“…Ballatori et al, 2009;Do et al, 2009;Martin and Teismann, 2009). However, antioxidant compounds generally exist in low concentration and non-invasive detection is therefore challenging.…”

Section: Antioxidant Defensementioning

confidence: 99%

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

et al. 2012

View full text Add to dashboard Cite

“…Ballatori et al, 2009;Do et al, 2009;Martin and Teismann, 2009). However, antioxidant compounds generally exist in low concentration and non-invasive detection is therefore challenging.…”

Section: Antioxidant Defensementioning

confidence: 99%

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

et al. 2012

View full text Add to dashboard Cite

“…[8][9][10][11] Supplementation with exogenous GSH has been suggested as a novel treatment for Parkinson's disease, 39) psychiatric disorders, 40) and diabetes. 41) In our previous study, the apparent molecular weight of RBPH was estimated around 300 Da, corresponding with the molecular weight of di-or tripeptides, and inhibitory peptides of DPP-IV from RBPH were successfully identified.…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidative Activity of Hydrolysate from Rice Bran Protein in HepG2 Cells

Moritani

Kawakami

Fujita

et al. 2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Glutathione (GSH) is an ubiquitous thiol-containing tripeptide, which plays important roles in cellular protection from oxidative stress. In our search for a dietary source that can increase GSH levels, we discovered that a 24 h treatment of HepG2 cells with rice bran protein hydrolysate (RBPH), prepared by Umamizyme G-catalyzed hydrolysis, increased the GSH content in a dose-dependent manner. RBPH elevated the expression levels of γ-glutamylcysteine synthetase (γ-GCS), which constitutes the rate-limiting enzyme of GSH synthesis, and of another two enzymes, hemeoxygenase-1 (HO-1) and reduced nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase 1 (NQO1). This induction was preceded by the accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) inside the nucleus, which is a key transcription factor for the expression of the γ-GCS, HO-1, and NQO1. Pre-treatment of cells with RBPH produced a significant protective effect against cytotoxicity caused by H 2 O 2 or ethanol. These results indicate that RBPH exerts a protective effect against oxidative stress by modulating GSH levels and anti-oxidative enzyme expression via the Nrf2 pathway.Key words rice bran; anti-oxidative; glutathione; nuclear factor erythroid 2-related factor 2 Rice is the most important cereal food in Japan. Rice bran (RB), which constitutes approximately 10% of the grain, is a major by-product of rice milling. RB is rich in protein, lipids, dietary fibers, and vitamins.1,2) Recently, RB was recognized as a functional ingredient, containing such antioxidants as tocopherols, tocotorienols, and γ-oryzanol.3,4) Moreover, enzymatically produced RB protein hydrolysates (RBPHs) were found to possess various biological functions with potential medical applications. In a previous study, we demonstrated that RBPH produced with Umamizyme G, a commercial protease from Aspergillus oryzae, from defatted RB protein exhibited the inhibitory activity of dipeptidylpetidase-IV (DPP-IV) that is a key regulator involved in the prevention and treatment of type 2 diabetes.5) RBPHs produced with other peptidases were shown to have an anti-proliferative effect on cancer cells, 6) and the ability to reduce micellar cholesterol levels. 7)

show abstract

“…In the brain tissue where there is paucity of antioxidant mechanisms, glutathione plays an important role in preventing oxidative stress and maintaining the redox equilibrium in the cell. Glutathione participates either by directly scavenging reactive oxygen and nitrogen intermediates (e.g., superoxide, nitric oxide, hydroxyl radical, and peroxynitrite) or by acting as a co-factor for glutathione peroxidase and glutathione reductase [44] [45]. In autistic children there is evidence for glutathione redox imbalance both in the peripheral blood and brain.…”

Section: Discussionmentioning

confidence: 99%

Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children

Abdel-Salam¹,

Youness²,

Mohammed³

et al. 2015

OJMIP

View full text Add to dashboard Cite

The aim of the present study was to investigate the status of oxidative stress in the serum of children affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched with 20 typically developing children. Changes in the levels of the redox-sensing transcription factor nuclear factor-kappa B (NF-κB) was measured in serum of autistic children and controls. Other oxidative stress biomarkers such as malondialdehyde, reduced glutathione, total antioxidant capacity, catalase activity, and paraoxonase 1 activity were determined in serum as well. Significant increase was observed in serum NF-κB of autistic children compared to that in controls (by 138.6%). There was also marked increase in malondialdehyde level by 87.3% in autistic patients. Meanwhile, there were significant decreases in reduced glutathione (by 24%), catalase activity (by 40.8%), paraoxonase 1 activity (by 36.6%), and total antioxidant capacity (by 36.5%) compared to the control group. These data clearly demonstrate increased oxidative stress in serum of autistic children and suggest that the NF-κB signaling pathway is activated in autism, possibly due to increased oxidative burden.

show abstract

Glutathione—a review on its role and significance in Parkinson's disease

Cited by 268 publications

References 92 publications

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

The neurochemical profile quantified by in vivo 1H NMR spectroscopy

Anti-oxidative Activity of Hydrolysate from Rice Bran Protein in HepG2 Cells

Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children

Contact Info

Product

Resources

About