Glutamine supplementation enhances mucosal immunity in rats with Gut-Derived sepsis

Lai, Yu Ni; Yeh, Sung Ling; Lin, Ming Tsan; Shang, Hung‐Sheng; Yeh, Chiu Li; Chen, Wei-Jen

doi:10.1016/j.nut.2003.11.015

Cited by 39 publications

(23 citation statements)

References 28 publications

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“…Finally, GLN improves the survival of animals after visceral or gut ischemia-reperfusion but not to the degree that normal oral feeding does, whereas arginine (ARG) may deteriorate the function of the mucosal barrier and enhance permeability [106,107]. GLN-enriched TPN preserved both extraintestinal and intestinal IgA levels and had a normalizing effect on Th2-type IgA-stimulating cytokines [105,108,109,110]. TPN reduced intestinal and respiratory IgA along with decreases in intestinal IL-4 and IL-10 compared with chow-fed animals.…”

Section: Glutamine-argininementioning

confidence: 99%

“…TPN reduced intestinal and respiratory IgA along with decreases in intestinal IL-4 and IL-10 compared with chow-fed animals. GLN significantly improves respiratory and intestinal IgA levels, significantly improved IL-4 compared with TPN animals, and maintained IL-10 levels midway between chow-fed and TPN animals [105,108,109,110]. Table 5 summarizes evidence about the role of GLN to the intestine and immune system [111,112,113,114,115,116,117].…”

Section: Glutamine-argininementioning

confidence: 99%

See 1 more Smart Citation

Artificial Nutrition and Intestinal Mucosal Barrier Functionality

Anastasilakis¹,

Ioannidis

Gkiomisi

et al. 2013

Digestion

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The gastrointestinal tract has a major role in digestion and absorption of nutrients while playing a leading role in defense of the body. It forms a shield against the invasion of various microorganisms or their products (e.g. antigens, toxins) and therefore it is important to establish its integrity and functionality. That depends on the route of administration and the composition of the artificial nutrition. This study concentrates on the influences of different kinds of artificial nutrition in the functionality of the intestinal mucosal barriers. It seems that full macromolecular solutions of enteral nutrition ensure an adequate mucous immune response, while a lack of nutritional stimulus in the lumen leads rapidly to a dysfunction of gastric-associated lymphatic tissue and mucosal immune system. This dysfunction renders the patients susceptible to infections in distant organs, hospital pneumonia, and multiorgan failure of non-infectious etiology. In patients with indication of total parenteral nutrition administration, addition of bombesin or glutamine preserves mucosal immune response and may limit the adverse effects.

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Section: Glutamine-argininementioning

confidence: 99%

Section: Glutamine-argininementioning

confidence: 99%

Artificial Nutrition and Intestinal Mucosal Barrier Functionality

Anastasilakis¹,

Ioannidis

Gkiomisi

et al. 2013

Digestion

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show abstract

“…That confers a key role to the level (quantity) and quality (amino acids) of proteins in the diet to optimise the immune response. The immunomodulatory roles of arginine, glutamine and taurine have been demonstrated and discussed (Evoy et al, 1998;Redmond et al, 1998;Shang et al, 2003. Lai et al, 2004.…”

Section: Proteins and Amino Acidsmentioning

confidence: 99%

A review on the interactions between gut microflora and digestive mucosal immunity. Possible ways to improve the health of rabbits

Fortun-Lamothe¹,

Boullier²

2007

Livestock Science

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“…This amino acid is also capable of regulating gene expression and cell signaling pathways in various cell types, including immunocytes (Li et al 2007). Results of recent compelling studies have indicated that glutamine regulates the general defense responses, including the production of cytokines (Ren et al 2013e), the function of immune cells Lai et al 2004), and the expression of innate immune regulators, e.g., like toll-like receptors (Ren et al 2013e) in various animal models. However, little is known about effects of dietary glutamine on general or specific defense responses in an animal model immunized with a vaccine.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

et al. 2014

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Little is known about effects of dietary glutamine supplementation on specific and general defense responses in a vaccine-immunized animal model. Thus, this study determined roles for dietary glutamine supplementation in specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine. The measured variables included: (1) the production of pathogen-specific antibodies; (2) mRNA levels for pro-inflammatory cytokines, toll-like receptors and anti-oxidative factors; and (3) the distribution of P. multocida in tissues and the expression of its major virulence factors in vivo. Dietary supplementation with 0.5 % glutamine had a better protective role than 1 or 2 % glutamine against P. multocida infection in vaccine-immunized mice, at least partly resulting from its effects in modulation of general defense responses. Dietary glutamine supplementation had little effects on the production of P. multocida-specific antibodies. Compared to the non-supplemented group, dietary supplementation with 0.5 % glutamine had no effect on bacterial burden in vivo but decreased the expression of major virulence factors in the spleen. Collectively, supplementing 0.5 % glutamine to a conventional diet provides benefits in vaccine-immunized mice by enhancing general defense responses and decreasing expression of specific virulence factors.

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Glutamine supplementation enhances mucosal immunity in rats with Gut-Derived sepsis

Cited by 39 publications

References 28 publications

Artificial Nutrition and Intestinal Mucosal Barrier Functionality

Artificial Nutrition and Intestinal Mucosal Barrier Functionality

A review on the interactions between gut microflora and digestive mucosal immunity. Possible ways to improve the health of rabbits

Effects of dietary l-glutamine supplementation on specific and general defense responses in mice immunized with inactivated Pasteurella multocida vaccine

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