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Ce‐doped Lu3Al5O12 optical ceramics co‐doped with Mg2+ are fabricated by solid‐state reaction method and further optimized by an air‐annealing process. Mg2+ co‐doping leads to a significant decrease of thermoluminescence intensity above room temperature and an increase of scintillation light yield (LY) value and fast component content even if the overall scintillation efficiency decreases. Scintillation LY of ∼21900 ph/MeV has been achieved with a short shaping time of 1 μs, and the ratio of LY values for 1 μs and 10 μs shaping times was as high as 79%. The acceleration of scintillation response induced by Mg2+ co‐doping and the role of Ce4+ ions in the scintillation mechanism are discussed.magnified image(© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

The research findings suggest that the majority of Chinese patients with RR-LSM are caused by a mild type of MADD with unique myopathy which is due to ETFDH gene mutation.

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Circulating tumor cells (CTCs) are important indicators for tumor diagnosis and tumor metastasis. However, the extremely low levels of CTCs in peripheral blood challenges the precise detection of CTCs. Herein, we report DNA generated electrochemical current combined with rolling circle amplification (RCA) as well as magnetic nanospheres for highly efficient magnetic capture and ultrasensitive detection of CTCs. The antiepithelial cell adhesion molecule (EpCAM) antibody-modified magnetic nanospheres were used to capture and enrich CTCs. The following binding of an aptamer onto the CTC surface and the subsequent RCA assembled a significant amount of DNA molecules onto the electrode. The reaction of the DNA molecules with molybdate can then form redox molybdophosphate and produce an electrochemical current. Using the breast cancer cell MCF-7 as a model, the sensor displays good performances toward detection of MCF-7 that was spiked into peripheral blood. The signal amplification strategy integrated with a magnetic nanosphere platform exhibits good performance in the efficient capture and detection of CTCs, which may find wide potential in cancer diagnostics and therapeutics.

ChiCTR-RRC-17014152.