A review on the interactions between gut microflora and digestive mucosal immunity. Possible ways to improve the health of rabbits

Fortun-Lamothe, Laurence; Boullier, Séverine

doi:10.1016/j.livsci.2006.09.005

Cited by 96 publications

(82 citation statements)

References 89 publications

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“…In the small intestine, GALT consists of organized lymphoid aggregates: Peyer's patches and isolated cells scattered in the lamina propria and the epithelium of the villi (for review Fortun-Lamothe and Boullier, 2007). Besides their barrier role, microbiota is involved in immune organs and cell development, diversification of antibodies and mechanisms of oral tolerance.…”

Section: Roles Of the Digestive Microbiotamentioning

confidence: 99%

Engineering the rabbit digestive ecosystem to improve digestive health and efficacy

Combes

Fortun-Lamothe

Cauquil

et al. 2013

Animal

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In rabbits, the bacterial and archaeal community of caecal ecosystem is composed mostly of species not yet described and very specific to that species. In mammals, the digestive ecosystem plays important physiological roles: hydrolysis and fermentation of nutrients, immune system regulation, angiogenesis, gut development and acting as a barrier against pathogens. Understanding the functioning of the digestive ecosystem and how to control its functional and specific diversity is a priority, as this could provide new strategies to improve the resistance of the young rabbit to digestive disorders and improve feed efficiency. This review first recalls some facts about the specificity of rabbit digestive microbiota composition in the main fermentation compartment, and its variability with some new insights based on recent molecular approaches. The main functions of the digestive microbiota will then be explained. Finally, some possible ways to control rabbit caecal microbiota will be proposed and a suitable timing for action will be defined.

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Section: Roles Of the Digestive Microbiotamentioning

confidence: 99%

Engineering the rabbit digestive ecosystem to improve digestive health and efficacy

Combes

Fortun-Lamothe

Cauquil

et al. 2013

Animal

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“…Qualitative and quantitative microbial colonization begin soon after birth, and develop gradually with age, rendering the maternal intestinal flora and surroundings as the main bacterial proliferation sources to the new-born digestive system (Fortun-Lamothe & Boullier, 2007;Steiner & Wegleitner, 2007). At this stage, this is a crucial process for all growing animals.…”

Section: Introductionmentioning

confidence: 99%

“…However, in commercially bred poultry the process of intestinal microflora development is delayed because of the lack of natural contact between chicks and mother hens (Applegate et al, 2010). Consequently, the digestive tract becomes burdened with distinguishing between nutrients and nonpathogenic microorganisms from harmful microorganisms while ensuring good nutrient absorption, but excluding digestive microorganisms, harmful and non-harmful (Fortun-Lamothe & Boullier, 2007;Leaphart & Tepas III, 2007).…”

Section: Introductionmentioning

confidence: 99%

Intestinal morphology, digestive organ size and digesta pH of broiler chickens fed diets supplemented with or without <i>Moringa oleifera</i> leaf meal

Nkukwana¹,

Muchenje²,

Masika³

et al. 2015

SA J. An. Sci.

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The intestinal morphology and pH of digesta of broiler chickens at 35 days old were studied. Birds were reared on these dietary treatments (T). T1, positive control, contained 668 g salinomycin and 500 g zinc bacitracin per kg of feed. Treatments, T2, T3 and T4, contained graded levels of Moringa oleifera leaf meal (MOLM) per kg of feed, namely starter (1, 3, 5 g), grower (3, 9, 15 g) and finisher (5, 15, 25 g). T5 was a negative control (without supplementation). Birds were provided feed and water ad libitum. Birds in T3 had the highest proventriculus digesta pH, and T5 birds the lowest. Birds that were supplemented with MOLMand surprisingly those from the negative control -had significantly higher caecal digesta pH, while T1 had the highest ileal digesta pH. Duodenal villous length was longest in T2, and shortest in T4. Jejunal villous length was longest in T3 and shortest in T2 birds. T3 and T4 jejunal villi were widest, with T1 birds having the shortest. Ileal villous was longest in T2 and T5 birds, while T3 birds had the shortest. Duodenal surface area for absorption was larger in T2 and T5, and smaller in T4, while T3 had the largest ileal surface area, and T1 the smallest. The jejunal surface area was largest in T3 (53.2) and T4 (50.7), and smallest in T1 (25.0). The current results reveal a regulatory effect of MOLM on the gastrointestinal tract, which could be attributed to the coarseness of the diets, thus raising the pH and resulting in thicker digesta viscosity, which is a clear sign of a healthy gut. ______________________________________________________________________________________

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“…application of stimulants, RNAi triggers or nucleic acid based recombinant viral coat proteins and antibodies to viral receptors), 3) the interest in the application of probiotics to promote health in cultured species (Verschuere et al, 2000), and 4) the rapid progress made with regard to the importance of gut immunity for regulating nutrition and disease in other vertebrate and invertebrate taxa (e.g. see Riddell et al, 2011 andreviews by Fortun-Lamothe &Boullier, 2007;Gomez & Balcazar, 2008;Fukatsu & Kudsk, 2011). From example Anthony et al…”

Section: The Importance Of Gut Immunitymentioning

confidence: 99%

The scope of the crustacean immune system for disease control

Hauton

2012

Journal of Invertebrate Pathology

133

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The culture or wild capture of marine and freshwater shellfish, including crustaceans, is without doubt a key source of protein for a burgeoning world population. Historically the expansion of aquaculture has, however, been accompanied by the increased incidence of economically significant diseases, most notably of viral and bacterial origin. Since the late 1970s great progress has been made in our understanding of the generalized protostome innate immune system. Distinct pathways, pathogen receptor proteins and effector molecules have since been identified that are not ancestral or homologous to those of the deuterostomes, including vertebrates. Within the past decade progress has accelerated with the rapid characterisation of new classes of recognition proteins, immune effectors and regulatory pathways. This paper provides a broad overview of our current understanding of invertebrate immunology, taking the crustacean decapod immune system as its focus. Recent developments in the field are described briefly and their implications and potential considered. These advances offer fundamental new insights in our efforts to understand disease in cultured populations and also to develop knowledge of environmental effects on host/pathogen interactions within a fishery context. Of course, challenges do remain, including the lack of an immortal cell line and the limited publically-available genomic resources. These are considered in this review as priorities for future research effort. With the continued application of more insightful technologies, coupled with associated investment, it is expected that the speed at which some of these issues are resolved will accelerate.

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A review on the interactions between gut microflora and digestive mucosal immunity. Possible ways to improve the health of rabbits

Cited by 96 publications

References 89 publications

Engineering the rabbit digestive ecosystem to improve digestive health and efficacy

Engineering the rabbit digestive ecosystem to improve digestive health and efficacy

Intestinal morphology, digestive organ size and digesta pH of broiler chickens fed diets supplemented with or without <i>Moringa oleifera</i> leaf meal

The scope of the crustacean immune system for disease control

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