Glucose-responsive UV polymerised dextran–concanavalin A acrylic derivatised mixtures for closed-loop insulin delivery

Tanna, Sangeeta; Taylor, M. Joan; Sahota, Tarsem; Sawicka, Kirsty

doi:10.1016/j.biomaterials.2005.08.011

Cited by 69 publications

(41 citation statements)

References 26 publications

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“…In our study, a single-cell suspension was prepared from spleens harvested from the antea-diabetic NOD mice. Each recipient NOD.Rag 12/2 mouse received 30310 6 splenocytes via an intraperitoneal injection.…”

Section: Spleen Cell Transfer Experimentsmentioning

confidence: 99%

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Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model

et al. 2012

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Previously, we established a model in which physiologically adequate function of the autologous b cells was recovered in non-obese diabetic (NOD) mice after the onset of hyperglycemia by rendering them hemopoietic chimera. These mice were termed antea-diabetic. In the current study, we addressed the role of T regulatory (Treg) cells in the mechanisms mediating the restoration of euglycemia in the antea-diabetic NOD model. The data generated in this study demonstrated that the numbers of Treg cells were decreased in unmanipulated NOD mice, with the most profound deficiency detected in the pancreatic lymph nodes (PLNs). The impaired retention of the Treg cells in the PLNs correlated with the locally compromised profile of the chemokines involved in their trafficking, with the most prominent decrease observed in SDF-1. The amelioration of autoimmunity and restoration of euglycemia observed in the antea-diabetic mice was associated with restoration of the Treg cell population in the PLNs. These data indicate that the function of the SDF-1/CXCR4 axis and the retention of Treg cells in the PLNs have a potential role in diabetogenesis and in the amelioration of autoimmunity and b cell regeneration in the antea-diabetic model. We have demonstrated in the antea-diabetic mouse model that lifelong recovery of the b cells has a strong correlation with normalization of the Treg cell population in the PLNs. This finding offers new opportunities for testing the immunomodulatory regimens that promote accumulation of Treg cells in the PLNs as a therapeutic approach for type 1 diabetes (T1D).

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Section: Spleen Cell Transfer Experimentsmentioning

confidence: 99%

“…The major milestones in solving the problem of insulin deficiency are: (i) the discovery of insulin; 1,2 (ii) pancreata and islets of Langerhans transplantation; 3,4 and (iii) development of insulin-supplying devices. 5,6 All of these contribute to symptomatic therapies that restore the insulin deficiency.…”

Section: Introductionmentioning

confidence: 99%

Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model

et al. 2012

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“…Polymerization of the gel components has been shown previously to prevent component leach during in vitro tests. 36 Bacterial and cellular invasion are resisted because of the pore size of the confining membranes.…”

Section: Device Set-upmentioning

confidence: 99%

“…This was feasible because in vitro studies with this system, as fully described elsewhere, 36,37 show that an insulin surge from the system can be reversed by dialyzing the glucose from the gel membrane thus restoring the low permeability condition appropriately. However, a negative feedback effect and the ability to equilibrate biologically at normal glucose levels would be difficult to prove other than in vivo in diabetic but otherwise normally functional animals with implanted devices.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

Taylor

Tanna

Sahota

2010

Journal of Pharmaceutical Sciences

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“…In this concept, the insulin dosage would be governed by the blood glucose levels on an automatic and continuous basis. An approach for a chemical self-regulated insulin delivery system based on a polymeric glucose-responsive biomaterial has been reported previously [8,9]. In this approach, the novel glucose-responsive biomaterial responds reversibly to glucose triggers and is being developed for use as part of an implantable self-regulated insulin delivery system.…”

Section: Introductionmentioning

confidence: 99%

The effect of degree of acrylic derivatisation on dextran and concanavalin A glucose-responsive materials for closed-loop insulin delivery

et al. 2006

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Glucose-responsive UV polymerised dextran–concanavalin A acrylic derivatised mixtures for closed-loop insulin delivery

Cited by 69 publications

References 26 publications

Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model

Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model

In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

The effect of degree of acrylic derivatisation on dextran and concanavalin A glucose-responsive materials for closed-loop insulin delivery

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