The effect of degree of acrylic derivatisation on dextran and concanavalin A glucose-responsive materials for closed-loop insulin delivery

Tanna, Sangeeta; Sahota, Tarsem; Sawicka, Kirsty; Taylor, M. Joan

doi:10.1016/j.biomaterials.2006.04.007

Cited by 62 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The release rate of model proteins through the glucose-sensitive hydrogel membrane was found to be well modulated by the concentration of free glucose. The release rate of the proteins did not remain constant, however, due to the change in free glucose concentration resulting from diffusion of glucose from the receptor chamber to the donor chamber [236][237][238]. For any glucose-sensitive insulin delivery system to be practically useful, fast removal of glucose after activating the glucose-sensitive hydrogel system is essential.…”

Section: Glucose-sensitive Gels-mentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

552

364

View full text Add to dashboard Cite

This review describes recent progresses in the development and applications of smart polymeric gels, especially in the context of biomedical devices. The review has been organized into three separate sections: defining the basis of smart properties in polymeric gels; describing representative stimuli to which these gels respond; and illustrating a sample application area, namely, microfluidics. One of the major limitations in the use of hydrogels in stimuli-responsive applications is the diffusion rate limited transduction of signals. This can be obviated by engineering interconnected pores in the polymer structure to form capillary networks in the matrix and by downscaling the size of hydrogels to significantly decrease diffusion paths. Reducing the lag time in the induction of smart responses can be highly useful in biomedical devices, such as sensors and actuators. This review also describes molecular imprinting techniques to fabricate hydrogels for specific molecular recognition of target analytes. Additionally, it describes the significant advances in bottom-up nanofabrication strategies, involving supramolecular chemistry. Learning to assemble supramolecular structures from nature has led to the rapid prototyping of functional supramolecular devices. In essence, the barriers in the current performance potential of biomedical devices can be lowered or removed by the rapid convergence of interdisciplinary technologies.

show abstract

Section: Glucose-sensitive Gels-mentioning

confidence: 99%

Smart polymeric gels: Redefining the limits of biomedical devices

Chaterji

Kwon

Park

2007

Progress in Polymer Science

552

364

View full text Add to dashboard Cite

show abstract

“…37 Briefly, methacrylated derivatives of dextran (RMM 70 kDa) and con A, to give each at a final content of 8.3% (w/w), were polymerized by UV irradiation for 70 min in the presence of the initiator Irgacure 1 2959 (0.178 mmol) and stored aseptically. Inactive control gels were produced using dex-MA (500 kDa) and bovine albumin-MA (Irgacure 1 2959 at 0.89 mmol for 70 min.…”

Section: Gel Manufacturementioning

confidence: 99%

“…This was feasible because in vitro studies with this system, as fully described elsewhere, 36,37 show that an insulin surge from the system can be reversed by dialyzing the glucose from the gel membrane thus restoring the low permeability condition appropriately. However, a negative feedback effect and the ability to equilibrate biologically at normal glucose levels would be difficult to prove other than in vivo in diabetic but otherwise normally functional animals with implanted devices.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

Taylor

Tanna

Sahota

2010

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…This approach could avoid modification of insulin which cost expensively and might bring associated problems. Some other researches [15][16][17][18][19] have developed Con A covalent-binding gels by using carbodiimide reaction, ring-opening reaction with methacrylic anhydride and other methods to covalently immobilize Con A to polymer matrix. As a result, the loss of Con A was restricted and the glucose-responsive properties of these systems were improved.…”

Section: Introductionmentioning

confidence: 99%