In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

Taylor, M. Joan; Tanna, Sangeeta; Sahota, Tarsem

doi:10.1002/jps.22138

Cited by 70 publications

(40 citation statements)

References 37 publications

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“…The aim of the solubility testing reported herein was to solubilize both drugs using the lowest concentration of excipients to minimize excipient-related toxicity [25][26][27][28]. NE and EE are poorly soluble drugs in aqueous solutions.…”

Section: Optimizing Concentrations Of the Excipientsmentioning

confidence: 99%

Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis

Abdallah

Hammell

Hassan

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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Section: Optimizing Concentrations Of the Excipientsmentioning

confidence: 99%

Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis

Abdallah

Hammell

Hassan

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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“…Based on the results of the biodistribution study, DTE, DTI, and DTP values were calculated for both intranasal 99m Tc-CZ solution and intranasal 99m Tc-PM7 (Table 7). DTE% represents time average partitioning of drug between brain and blood (Haque et al, 2014), while DTI is a measure of the differential targeting between intranasal and intravenous delivery (Taylor et al, 2010) and DTP% represents the percent of drug directly transported to the brain by the olfactory and trigeminal neural pathway (Haque et al, 2014). Their values were 242.…”

Section: Biodistribution Studymentioning

confidence: 99%

Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies

et al. 2016

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Clonazepam (CZ) is an anti-epileptic drug used mainly in status epilepticus (SE). The drug belongs to Class II according to BCS classification with very limited solubility and high permeability and it suffers from extensive first-pass metabolism. The aim of the present study was to develop CZ-loaded polymeric micelles (PM) for direct brain delivery allowing immediate control of SE. PM were prepared via thin film hydration (TFH) technique adopting a central composite face-centered design (CCFD). The seventeen developed formulae were evaluated in terms of entrapment efficiency (EE), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and in vitro release. For evaluating the in vivo behavior of the optimized formula, both biodistrbution using 99m Tc-radiolabeled CZ and pharmacodynamics studies were done in addition to ex vivo cytotoxicty. At a drug:Pluronic Õ P123:Pluronic Õ L121 ratio of 1:20:20 (PM7), a high EE, ZP, Q8h, and a low PDI was achieved. The biodistribution studies revealed that the optimized formula had significantly higher drug targeting efficiency (DTE ¼ 242.3%), drug targeting index (DTI ¼ 144.25), and nose-to-brain direct transport percentage (DTP ¼ 99.30%) and a significant prolongation of protection from seizures in comparison to the intranasally administered solution with minor histopathological changes. The declared results reveal the ability of the developed PM to be a strong potential candidate for the emergency treatment of SE.

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“…A disadvantage of water as antisolvent successfully circumvented by US application is a delayed mixing rate between the solution and antisolvent owing to a low diffusivity of water in organic solutions. [37,38] …”

Section: Antisolvent Sonocrystallizationmentioning

confidence: 99%

A Review: Meltsonocrystallization Technique Used for Improvement of Solubility

Sardar¹

2017

WJPPS

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Melt sonocrystallization method have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. It is a novel particle engineering technique to enhance dissolution of hydrophobic drugs that is having less water solubility and to study its effect on crystal properties of drug. It forms agglomerates with number of shallow circular pits on the surface leads to increase solubility by improving its shape from crystalline to amorphous that is obtain circular shape. Melt sonocrystallization process was developed for poorly soluble drugs in which these poorly soluble drugs melt was poured in deionized water maintained at 60 0 C and simultaneously subjected to ultrasonic energy.The agglomerates obtained after solidification of dispersed droplets were separated by filtration and dried at room temperature. Hence this review gives valuable information about on melt-sonocrystallization shows that there is increase in solubility of poorly water soluble drugs.

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In Vivo Study of a Polymeric Glucose-Sensitive Insulin Delivery System Using a Rat Model

Cited by 70 publications

References 37 publications

Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis

Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis

Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies

A Review: Meltsonocrystallization Technique Used for Improvement of Solubility

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