Glucose hydrogenolysis over Cu-La2O3/Al2O3: Mechanistic insights

Yazdani, Parviz; Wang, Bo; Rimaz, Sajjad; Kawi, Sibudjing; Borgna, Armando

doi:10.1016/j.mcat.2018.12.016

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…No differences in mobility between control and healed SC could be detected at hydrated conditions, except for a slightly higher mobility of the lipid chain terminal ωCH 3 and Chol in healed SC. For healed SC, we observed an additional signal at 63.5 ppm and a few weak signals between 65 and 100 ppm, which could be attributed to the presence of a carbohydrate moiety from glycosphingolipids present in the sample [ 80 , 81 ]. Note, we did not notice any mobility in the protein segments even at 97% RH in either control or healed SC, which differed from previous observations from samples of pig ear SC [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs

Mojumdar

Madsen²,

Hansson

et al. 2021

Biomedicines

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Proper skin barrier function is paramount for our survival, and, suffering injury, there is an acute need to restore the lost barrier and prevent development of a chronic wound. We hypothesize that rapid wound closure is more important than immediate perfection of the barrier, whereas specific treatment may facilitate perfection. The aim of the current project was therefore to evaluate the quality of restored tissue down to the molecular level. We used Göttingen minipigs with a multi-technique approach correlating wound healing progression in vivo over three weeks, monitored by classical methods (e.g., histology, trans-epidermal water loss (TEWL), pH) and subsequent physicochemical characterization of barrier recovery (i.e., small and wide-angle X-ray diffraction (SWAXD), polarization transfer solid-state NMR (PTssNMR), dynamic vapor sorption (DVS), Fourier transform infrared (FTIR)), providing a unique insight into molecular aspects of healing. We conclude that although acute wounds sealed within two weeks as expected, molecular investigation of stratum corneum (SC) revealed a poorly developed keratin organization and deviations in lipid lamellae formation. A higher lipid fluidity was also observed in regenerated tissue. This may have been due to incomplete lipid conversion during barrier recovery as glycosphingolipids, normally not present in SC, were indicated by infrared FTIR spectroscopy. Evidently, a molecular approach to skin barrier recovery could be a valuable tool in future development of products targeting wound healing.

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Section: Resultsmentioning

confidence: 99%

Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs

Mojumdar

Madsen²,

Hansson

et al. 2021

Biomedicines

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“…As a result, a wide range of products is obtained. To enhance selectivity, many monometallic catalysts based on Cu, Ni, Pt or Ru were developed and tested in combination with a homogeneous base [8–14] . Additionally, recent research focused on the development of bimetallic catalysts to facilitate reactions with the addition of a solid base, without external hydrogen pressure or to further enhance selectivity [15–24] …”

Section: Introductionmentioning

confidence: 99%

Ru on N‐doped Carbon for the Selective Hydrogenolysis of Sugars and Sugar Alcohols

et al. 2022

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Glycols are accessible via metal-catalyzed hydrogenolysis of sugar alcohols such as xylitol obtained from hemicellulose. Rubased catalysts are highly active but also catalyze side-reactions such as decarbonylation and deoxygenation. To achieve high selectivity, these reactions need to be suppressed. In our study, we introduce heteroatom doped carbon materials as catalyst supports providing high selectivity. Heteroatom doping with nitrogen and oxygen was achieved by treating activated carbon with HNO 3 , NH 3 and H 2 or carbonization of organic precursors.For all N-doped materials a high glycol selectivity of �80 % for sorbitol and xylitol and 44 % for xylose and glucose was reached. XPS analysis confirms the presence of different nitrogen species at the carbon surface and varying ligand effects for oxygen and nitrogen. Oxygen has an electron withdrawing effect on ruthenium and leads to a decreased activity. Nitrogen has weaker electron withdrawing properties, resulting in an enhanced selectivity.

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“…The enzymatic production of d -fructose is highly selective, while it remains challenging because the application of this biocatalyst requires strict feed purification, careful temperature control, periodic catalyst change, and the use of buffer solutions. , Because these complex processing steps are demanded to prevent enzyme deactivation, considerable efforts have been devoted to finding nonenzymatic catalysts for the production of d -fructose or HFCS from d -glucose. Lewis acids, such as Sn-beta zeolite and metal halides (AlCl 3 , CrCl 3 , SnCl 4 , and so on), have been developed and employed as effective chemical catalysts for the isomerization of d -glucose. − Besides, a variety of homogeneous Brønsted bases and some heterogeneous base catalysts, for example, hydrotalcite and metal oxides, can also catalyze this isomerization reaction, which follows the Lobry de Bruyn–Alberda van Ekenstein (LdB–AvE) mechanism. − However, the above-mentioned catalysts still exhibit some disadvantages, for instance, some are environmentally unfriendly, toxic, and generate a lot of byproducts. Hence, there still is a demand for nontoxic, green, catalysts for the d -glucose isomerization reaction.…”

Section: Introductionmentioning

confidence: 99%

d-Glucose Isomerization with PAMAM Dendrimers as Environmentally Friendly Catalysts

Guo

Pedersen

Wang

et al. 2021

J. Agric. Food Chem.

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The isomerization of D-glucose to D-fructose plays a key role in the biochemical and chemical conversion of biomass, and it is therefore desirable to develop and improve catalysts for this reaction. In this study, the environmentally friendly polymer poly(amidoamine) (PAMAM) dendrimer's properties as catalysts for this isomerization are investigated. The experimental results showed that the PAMAM dendrimers, which have basic terminal groups, can effectively promote the D-glucose isomerization reaction. Under the optimized reaction conditions, D-fructose was generated with a 20% maximum yield and above 90% selectivity. 13C and 2 H isotope experiments by NMR were carried out to explore the reaction mechanism. When the reaction was performed in D 2 O, the C1 signal of D-fructose changed to a triplet, which confirmed that the C1 carbon binds to a deuterium atom, i.e., isotopic exchange. It was also found that the deuterium atom at the C2 position of D-glucose-2-d 1 cannot transfer to D-fructose. These data indicate that PAMAM dendrimers catalyze D-glucose isomerization through a mechanism, which includes deprotonation, formation of ene-diol intermediate, and proton exchange with the solvent.

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Glucose hydrogenolysis over Cu-La2O3/Al2O3: Mechanistic insights

Cited by 16 publications

References 27 publications

Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs

Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs

Ru on N‐doped Carbon for the Selective Hydrogenolysis of Sugars and Sugar Alcohols

d-Glucose Isomerization with PAMAM Dendrimers as Environmentally Friendly Catalysts

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