Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices

Pullano, Salvatore A.; Greco, Marta; Bianco, Maria Giovanna; Foti, Daniela; Brunetti, Antonio; Fiorillo, Antonino S.

doi:10.7150/thno.64035

Cited by 89 publications

(43 citation statements)

References 169 publications

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“…Although an old patent based on an assumptive fluorescence of glucose excited at 308 nm is reported, glucose actually has no detectable fluorescence when excited in the visible or near-UV range ( Khalil, 2004 ; Pullano et al, 2022 ). Fluorescence technologies make instead use of fluorophores that, once bound to the analyte (e.g., glucose), are able to emit fluorescent light with distinctive optical properties (mostly, excitation and detection wavelengths).…”

Section: Blood Glucose Monitoring Devicesmentioning

confidence: 99%

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Todaro

Begarani²,

Sartori³

et al. 2022

Front. Chem.

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Diabetes has no well-established cure; thus, its management is critical for avoiding severe health complications involving multiple organs. This requires frequent glycaemia monitoring, and the gold standards for this are fingerstick tests. During the last decades, several blood-withdrawal-free platforms have been being studied to replace this test and to improve significantly the quality of life of people with diabetes (PWD). Devices estimating glycaemia level targeting blood or biofluids such as tears, saliva, breath and sweat, are gaining attention; however, most are not reliable, user-friendly and/or cheap. Given the complexity of the topic and the rise of diabetes, a careful analysis is essential to track scientific and industrial progresses in developing diabetes management systems. Here, we summarize the emerging blood glucose level (BGL) measurement methods and report some examples of devices which have been under development in the last decades, discussing the reasons for them not reaching the market or not being really non-invasive and continuous. After discussing more in depth the history of Raman spectroscopy-based researches and devices for BGL measurements, we will examine if this technique could have the potential for the development of a user-friendly, miniaturized, non-invasive and continuous blood glucose-monitoring device, which can operate reliably, without inter-patient variability, over sustained periods.

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Section: Blood Glucose Monitoring Devicesmentioning

confidence: 99%

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Todaro

Begarani²,

Sartori³

et al. 2022

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…Specific oxidases are immobilised onto the electrode surface, converting the non-electroactive biological target to H 2 O 2 for the subsequent in vitro detection of the attendant targeted molecule. This type of screening has been mainly used in the enzymatic detection of glucose by involving glucose oxidase (GOx) assistance in biosensing due to their crucial role in controlling glucose in diabetic patients [ 49 ].…”

Section: Hydrogen Peroxide Electrochemical Detectionmentioning

confidence: 99%

Low Platinum-Content Electrocatalysts for Highly Sensitive Detection of Endogenously Released H2O2

et al. 2022

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The commercial viability of electrochemical sensors requires high catalytic efficiency electrode materials. A sluggish reaction of the sensor’s primary target species will require a high overpotential and, consequently, an excessive load of catalyst material to be used. Therefore, it is essential to understand nanocatalysts’ fundamental structures and typical catalytic properties to choose the most efficient material according to the biosensor target species. Catalytic activities of Pt-based catalysts have been significantly improved over the decades. Thus, electrodes using platinum nanocatalysts have demonstrated high power densities, with Pt loading considerably reduced on the electrodes. The high surface-to-volume ratio, higher electron transfer rate, and the simple functionalisation process are the main reasons that transition metal NPs have gained much attention in constructing high-sensitivity sensors. This study has designed to describe and highlight the performances of the different Pt-based bimetallic nanoparticles and alloys as an enzyme-free catalytic material for the sensitive electrochemical detection of H2O2. The current analysis may provide a promising platform for the prospective construction of Pt-based electrodes and their affinity matrix.

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“…In healthcare modern diagnostic approaches and therapies, implantable bioelectronic devices can improve the clinical outcome of the patient, obtaining a large amount of data [ 7 , 8 , 9 ]. Innovative devices are usually light, allowing the patient to conduct normal daily activities [ 10 , 11 , 12 ]. Energy storage is by far one of the bottlenecks, preventing efficient energy management [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Reflective Zeolite Coating for Implantable Bioelectronic Devices

et al. 2022

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Since sunlight is one of the most easily available and clean energy supplies, solar cell development and the improvement of its conversion efficiency represent a highly interesting topic. Superficial light reflection is one of the limiting factors of the photovoltaic cells (PV) efficiency. To this end, interfacial layer with anti-reflective properties reduces this phenomenon, improving the energy potentially available for transduction. Nanoporous materials, because of the correlation between the refractive index and the porosity, allow low reflection, improving light transmission through the coating. In this work, anti-reflective coatings (ARCs) deposited on commercial PV cells, which were fabricated using two different Linde Type A (LTA) zeolites (type 3A and 4A), have been investigated. The proposed technique allows an easier deposition of a zeolite-based mixture, avoiding the use of chemicals and elevated temperature calcination processes. Results using radiation in the range 470–610 nm evidenced substantial enhancement of the fill factor, with maximum achieved values of over 40%. At 590 and 610 nm, which are the most interesting bands for implantable devices, FF is improved, with a maximum of 22% and 10%, respectively. ARCs differences are mostly related to the morphology of the zeolite powder used, which resulted in thicker and rougher coatings using zeolite 3A. The proposed approach allows a simple and reliable deposition technique, which can be of interest for implantable medical devices.

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Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices

Cited by 89 publications

References 169 publications

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Is Raman the best strategy towards the development of non-invasive continuous glucose monitoring devices for diabetes management?

Low Platinum-Content Electrocatalysts for Highly Sensitive Detection of Endogenously Released H2O2

Anti-Reflective Zeolite Coating for Implantable Bioelectronic Devices

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