A series of aryldiazonium tetrafluorborates dissolved in nitriles have been converted into the corresponding anilides in almost quantitative yield in 1 min by microwave irradiation. When bromoacetonitrile was used, 2,4-bis(bromophenyl)-quinazoline was formed. The reaction of malononitrile with the diazonium salt, in DMF as a solvent, afforded 2-(dimethylaminomethylene) malononitrile and phenylhydrazone propanedinitrile.
The adoption of new measures that preserve our environment, on which our survival depends, is a necessity. Electro‐organic processes are sustainable per se, by producing the activation of a substrate by electron transfer at normal pressure and room temperature. In the recent years, a highly crescent number of works on organic electrosynthesis are available. Novel strategies at the electrode are being developed enabling the construction of a great variety of complex organic molecules. However, the possibility of being scaled‐up is mandatory in terms of sustainability. Thus, some electrochemical methodologies have demonstrated to report the best results in reducing pollution and saving energy. In this personal account, these methods have been compiled, being organized as follows: • Direct discharge electrosynthesis • Paired electrochemical reactions. and • Organic transformations utilizing electrocatalysis (in absence of heavy metals). Selected protocols are herein presented and discussed with representative recent examples. Final perspectives and reflections are also considered.
Cyanoacetic acid is formed by cathodic reduction of CO(2) and anodic oxidation of the tetraalkylammonium salt anion; the process is conduced in acetonitrile using a divided cell with a medium porosity glass-frit diaphragm. A mechanism for this paired electrochemical reaction is proposed.
Hybrid nanoparticles appear to be a promising platform for long-term drug release, presenting the desired structure and a robust performance for targeted anticancer therapy.
The electrochemical reduction of phenacyl azides (1a−e) leads to the formation of 2-aroyl-4-arylimidazoles (2a−e) (70−80% yield). 1a−e were
prepared from phenacyl bromides and sodium azide and were reduced in aprotic DMF-LiClO4 medium at the mercury cathode in a divided cell
and under controlled potential.
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