Glucose Biosensor Based on Chitosan-Gold and Prussian Blue-Gold Nanoparticles

Kulys, Juozas; Stupak, Robert

doi:10.2174/1874140100802010034

Cited by 17 publications

(7 citation statements)

References 16 publications

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“…The sensor without CS protection showed the PB desorption from the electrode within 10 min. The CS nanocomposite matrix provides better surface protection for the immobilized enzyme when continuous functioning for more than 2 h. [132]. Furthermore, a homogenous CS with Fc and AuNPs-GOx biocomposite film was deposited by simple and controllable electro-catalytic methods to fabricate glucose sensor.…”

Section: Sol-gel Castingmentioning

confidence: 99%

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Bagal-Kestwal

Chiang

2019

Polymers

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The nanomaterial-integrated chitinous polymers have promoted the technological advancements in personal health care apparatus, particularly for enzyme-based devices like the glucometer. Chitin and chitosan, being natural biopolymers, have attracted great attention in the field of biocatalysts engineering. Their remarkable tunable properties have been explored for enhancing enzyme performance and biosensor advancements. Currently, incorporation of nanomaterials in chitin and chitosan-based biosensors are also widely exploited for enzyme stability and interference-free detection. Therefore, in this review, we focus on various innovative multi-faceted strategies used for the fabrication of biological assemblies using chitinous biomaterial interface. We aim to summarize the current development on chitin/chitosan and their nano-architecture scaffolds for interdisciplinary biosensor research, especially for analytes like glucose. This review article will be useful for understanding the overall multifunctional aspects and progress of chitin and chitosan-based polysaccharides in the food, biomedical, pharmaceutical, environmental, and other diverse applications.

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Section: Sol-gel Castingmentioning

confidence: 99%

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Bagal-Kestwal

Chiang

2019

Polymers

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“…Several examples report the growth of gold nanoparticles in the presence of chitosan for different applications. For instance, an amperometric glucose biosensor was constructed by incorporating GOD in the biocompatible hybrid matrix, which was deposited on an electrode previously modified with Au-Prussian Blue (PB) nanoparticles [195]. The Au-chitosan matrix was also employed for immobilization of leukemia cells on electrodes, in order to monitor cell adhesion, proliferation and apoptosis by impedance measurements [196].…”

Section: Bionanocomposites For Sensor Devices and Other Applicationsmentioning

confidence: 99%

Progress in Bionanocomposite Materials

Ruiz‐Hitzky

Darder

2009

Annual Review of Nano Research

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The present review chapter includes an overview on the current state-of-art of bionanocomposites, which are an emerging class of nanostructured biohybrid materials. In the same way than conventional nanocomposites, these biohybrid materials also exhibit both structural and functional properties together with biocompatibility and biodegradability, which can be of great interest for different applications. Three main areas of interest have been identified, those dealing with the development of green nanocomposites, bionanocomposites addressed to biomedical purposes, as well as bionanohybrids for uses in advanced devices.

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“…Several nanocomposites H935 which consist of a mixture of GRP, metal or metal oxide nanoparticles, and CHIT have been fabricated which, altogether, exhibit a new and unambiguous electrochemical behavior. 76,77 In the present work, a TiO 2 /GRP/CHIT nanocomposite modified GCE has been fabricated and shown to exhbit higher electrocatalytic behavior toward the electro-oxidation of TPT as compared to the other three electrodes; i.e., GCE, TiO 2 /GCE, and TiO 2 /GRP/GCE. Furthermore, the analytical application of the proposed method was extended toward its determination in pharmaceutical formulation without any interference from foreign species.…”

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confidence: 93%

TiO₂/Graphene/Chitosan-Nanocomposite-Based Electrochemical Sensor for the Sensing of Anti-HIV Drug Topotecan

Saxena

Shrivastava

Satsangee

et al. 2014

J. Electrochem. Soc.

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A highly sensitive and stable TiO 2 /graphene/chitosan (TiO 2 /GRP/CHIT) modified glassy carbon electrode was developed. The sensor exhibits excellent electrocatalytic activity with fast response and convenient determination of an anti-HIV drug Topotecan (TPT). Moreover, from the response characteristics of cyclic voltammetry(CV) and square wave voltammetry (SWV), it was observed that TPT could be effectively accumulated at TiO 2 /GRP/CHIT/GCE and resulted in a sensitive anodic peak current in Britton-Robinson buffer (pH 5.6). Under the optimized experimental conditions, electro-oxidation of TPT demonstrates linearity within a dynamic concentration of 100 to 1200 ng/mL, with a detection limit of 122.07 ng/mL (LOD) and a quantification limit of 369.9 ng/mL (LOQ). On the basis of the electrochemical measurements, electrode dynamics parameters have been evaluated and the sensor has been successfully employed for determination of TPT in pharmaceutical formulation. -ethyl-4,9-dihydroxy-1H-pyrano[3 ,4 :6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (Scheme 1), is a derivative of the plant alkaloid camptothecin. It has been found to decrease replication and is a potent and selective inhibitor of both acute and chronic human immunodeficiency virus type-1 infections. 1,2 TPT works on topoisomerase, which is found in both proliferating and non-proliferating cells. Furthermore, TPT also possesses a wide range of biological and therapeutic properties. [3][4][5][6] Because drug analysis has an extensive impact on public health, the development of a quick and sensitive method for the analysis of the active ingredients to avoid inappropriate dosing which can cause adverse side reactions is important. Several techniques have been explored for the determination of TPT, including liquid chromatography-mass spectrometry (LC-MS), 7,8 LC, 9 HPLC, and RP-HPLC. 10-14 However, these techniques are extremely time intensive as they are coupled with complicated preconcentration steps due to the complexity of the real samples and the low concentration of the analyte and above all they require expensive equipment which is not always available. Electrochemical methods are now being explored because of their immense advantages over the conventional techniques, such as high sensitivity, selectivity, and fast detection, and above all their being quite inexpensive. Additional application of electrochemistry includes the determination of the redox properties of drugs which provides an insight into their metabolic fate and the in-vivo redox process which makes it easier to understand the pharmacological activities. [15][16][17][18][19][20][21][22][23][24] The development of electrochemical sensors for the analysis of pharmaceutically important compounds with respect to their sensitivity, accuracy, and simplicity have been of greater interest in recent years.Modified electrodes have recently received tremendous interest largely because they have a wide range of potential applications in electrochemical technology, energy conversion, and, particul...

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Glucose Biosensor Based on Chitosan-Gold and Prussian Blue-Gold Nanoparticles

Cited by 17 publications

References 16 publications

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Progress in Bionanocomposite Materials

TiO₂/Graphene/Chitosan-Nanocomposite-Based Electrochemical Sensor for the Sensing of Anti-HIV Drug Topotecan

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Glucose Biosensor Based on Chitosan-Gold and Prussian Blue-Gold Nanoparticles

Cited by 17 publications

References 16 publications

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Exploration of Chitinous Scaffold-Based Interfaces for Glucose Sensing Assemblies

Progress in Bionanocomposite Materials

TiO2/Graphene/Chitosan-Nanocomposite-Based Electrochemical Sensor for the Sensing of Anti-HIV Drug Topotecan

Contact Info

Product

Resources

About

TiO₂/Graphene/Chitosan-Nanocomposite-Based Electrochemical Sensor for the Sensing of Anti-HIV Drug Topotecan