Glucose and lipid metabolism after liver transplantation in inbred rats: consequences of hepatic denervation

Kißler, Hermann; Hauffen, Jürgen; Hennig, René; Gepp, H.; Schwille, P. O.

doi:10.1016/j.metabol.2005.01.036

Cited by 14 publications

(9 citation statements)

References 39 publications

(56 reference statements)

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“…4C), reinforcing our dysbalance hypothesis. The results, obtained after complete hepatic denervation, are also in agreement with studies performed after liver transplantation in which no abnormal liver metabolism has been reported, confirming that the ANS is not essential for hepatic glucose metabolism (31)(32)(33). The absence of a glucose rhythm in HSx or HPx animals subjected to a noncircadian feeding regimen, despite an intact corticosterone rhythm (Fig.…”

Section: Autonomic Regulation Of Blood Glucose Rhythmsupporting

confidence: 89%

Daily Rhythms in Metabolic Liver Enzymes and Plasma Glucose Require a Balance in the Autonomic Output to the Liver

et al. 2008

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Daily variations in plasma glucose concentrations are controlled by the biological clock, located in the suprachiasmatic nucleus. Our previous studies indicated an important role for the sympathetic innervation of the liver in the generation of the daily glucose rhythm. In the present study, we investigated further the role of the autonomic nervous system (ANS) in the genesis of the plasma glucose rhythm. First, we showed that complete removal of the autonomic inputs to the liver did not impair the plasma glucose rhythm or the daily expression of the glucoregulatory enzymes in the liver. Consequently, we studied whether the daily glucose rhythm is driven by the daily feeding activity in denervated animals. Surprisingly, complete denervation combined with a noncircadian feeding schedule also did not abolish the 24-h profile in plasma glucose or all daily rhythms in the gene expression of liver enzymes. These results demonstrate that the mechanisms used by the suprachiasmatic nucleus to control the rhythmic expression of glucose-metabolizing enzymes and the 24-h rhythm in plasma glucose concentrations are highly versatile and the glucose rhythm can be maintained in absence of hepatic ANS input and/or a day/night rhythm in feeding activity. Interestingly, a hepatic sympathectomy or parasympathectomy did abolish the plasma glucose rhythm, demonstrating that a unilateral denervation of the liver is more deleterious to maintaining the rhythmic liver metabolism than a complete removal of both branches. This observation supports the notion that an unbalanced ANS in obesity and diabetes accounts for the disturbed glucose balance in these disorders.

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Section: Autonomic Regulation Of Blood Glucose Rhythmsupporting

confidence: 89%

Daily Rhythms in Metabolic Liver Enzymes and Plasma Glucose Require a Balance in the Autonomic Output to the Liver

et al. 2008

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“…Vagal afferents in the hepatic portal contain glucagon-like peptide-1 receptors that convey information about peripheral glucose status to the brain. In addition, vagal efferent fibers innervate the liver and the kidneys and play a role in glucose regulation [ 49 – 51 ]. The association between vagal activity and glucose levels has been previously shown to be stronger during nighttime [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Associations of Self-Rated Health: Heart Rate Variability Is More Strongly Associated than Inflammatory and Other Frequently Used Biomarkers in a Cross Sectional Occupational Sample

et al. 2015

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The present study aimed to investigate the possible mechanisms linking a single–item measure of global self-rated health (SRH) with morbidity by comparing the association strengths between SRH with markers of autonomic nervous system (ANS) function, inflammation, blood glucose and blood lipids. Cross–sectional comprehensive health–check data of 3947 working adults (age 42±11) was used to calculate logistic regressions, partial correlations and compare correlation strength using Olkins Z. Adjusted logistic regression models showed a negative association between SRH (higher values indicating worse health) and measures of heart rate variability (HRV). Glycemic markers were positively associated with poor SRH. No adjusted association was found with inflammatory markers, BP or lipids. In both unadjusted and adjusted linear models Pearson’s correlation strength was significantly higher between SRH with HRV measures compared to SRH with other biomarkers. This is the first study investigating the association of ANS function and SRH. We showed that a global measure of SRH is associated with HRV, and that all measures of ANS function were significantly more strongly associated with SRH than any other biomarker. The current study supports the hypothesis that the extent of brain–body communication, as indexed by HRV, is associated with self-rated health.

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“…Pretreatment with 95% hydroalcoholic extract of Barleria Montana restored the level of bilirubin to near normal, suggesting that Barleria Montana stabilizes biliary dysfunction of rat liver. The cholesterol levels are increased which might be due to uptake of LDL from the blood by the tissues 26 . Thus, 95% hydroalcoholic extract of Barleria Montana may be effective on reduced cholesterol synthesis, and there by causes increased HDL levels.…”

Section: Discussionmentioning

confidence: 99%

Antihepatotoxic Effect of Barleria Montana Leaves Against Anti-Tb Drugs Induced Hepatotoxicity

Basini¹,

Lakshmi²,

Anitha³

2013

Int. Res. J. Pharm.

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Introduction: The present study was undertaken to evaluate the protective activity of 95% hydroalcoholic extract of Barleria Montana leaves against anti-TB drugs induced hepatotoxicity. Methods: Hepatotoxicity was induced by anti-TB drugs once daily for 35 days and simultaneously 95% hydroalcoholic extract of Barleria Montana (250 & 500 mg/kg p.o.) was administered one hour prior administration of anti-TB drugs. Silymarin was used as standard drug (100 mg/kg p.o.). Results: Elevated levels of SGOT, SGPT, ALP, TB & total cholesterol and decreased total HDL following anti-TB drugs administration. Pretreatment of 95% hydroalcoholic extract of Barleria Montana with anti-TB drugs were significantly reduced biochemical markers and increased total HDL. In vivo antioxidant parameters such as SOD, CAT, GSH, GPx and GRx were suppressed in hepatic control animals. Pre treatment of 95% hydroalcoholic extract of Barleria Montana with anti-TB drugs significantly reduced lipid per oxidation and increased antioxidant activities. Conclusion: The result of the present study was indicated that Barleria Montana showed protective effect on liver toxicity induced by anti-TB drugs might be attributed to its antioxidant activity.

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Glucose and lipid metabolism after liver transplantation in inbred rats: consequences of hepatic denervation

Cited by 14 publications

References 39 publications

Daily Rhythms in Metabolic Liver Enzymes and Plasma Glucose Require a Balance in the Autonomic Output to the Liver

Daily Rhythms in Metabolic Liver Enzymes and Plasma Glucose Require a Balance in the Autonomic Output to the Liver

Investigating the Associations of Self-Rated Health: Heart Rate Variability Is More Strongly Associated than Inflammatory and Other Frequently Used Biomarkers in a Cross Sectional Occupational Sample

Antihepatotoxic Effect of Barleria Montana Leaves Against Anti-Tb Drugs Induced Hepatotoxicity

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