Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs

Kongara, Kavitha; Chambers, Paul; Johnson, Craig B.

doi:10.1111/j.1467-2995.2008.00430.x

Cited by 28 publications

(20 citation statements)

References 43 publications

(51 reference statements)

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“… GFR, glomerular filtration rate; CI, confidence intervals. a Finco et al, 1981; Krawiec et al, 1986; Watson et al, 2002 b Fettman et al, 1985; Watson et al, 2002 c Bovee and Joyce, 1979; Finco et al, 1981; Krawiec et al, 1986; Watson et al, 2002; Narita et al, 2006 d Finco et al, 1981; Labato and Ross, 1991; Watson et al, 2002 e Labato and Ross, 1991; Watson et al, 2002; Cortadellas et al, 2008; Panciera and Lefebvre, 2009 f Goy-Thollot et al, 2006b; Lefebvre et al, 2006; O’Dell Anderson et al, 2006; Bexfield et al, 2008; Kongara et al, 2009 g 95% CI only calculated for GFR techniques with a minimum of five reported mean measurements h Weighted mean GFR after exclusion of outlying study (Labato and Ross, 1991) = 3.30 i 95% CI after exclusion of outlying study (Labato and Ross, 1991) = 2.96–3.64. …”

Section: Figures and Tablesmentioning

confidence: 99%

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An overview of glomerular filtration rate testing in dogs and cats

Hendy-Willson

Pressler

2011

The Veterinary Journal

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Determination of glomerular filtration rate (GFR) is a valuable, yet underused, diagnostic tool for evaluating renal function in dogs and cats. This article first reviews the hormonal and hemodynamic factors which contribute to GFR, followed by a description of considerations when selecting a pharmacokinetic model and methods of animal-to-animal standardization. The bestcharacterized existing GFR markers, including creatinine, radiolabeled markers, and iohexol, are reviewed in depth, as well as alternative but lesser-used techniques. A weighted means analysis of reported GFR measurements in healthy dogs and cats and a review of selected studies that have examined GFR alterations in animals with naturally-occurring and experimental diseases provide the reader with preliminary guidelines on expected GFR results in these species and disease conditions.

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Section: Figures and Tablesmentioning

confidence: 99%

“… f Goy-Thollot et al, 2006b; Lefebvre et al, 2006; O’Dell Anderson et al, 2006; Bexfield et al, 2008; Kongara et al, 2009 …”

Section: Figures and Tablesmentioning

confidence: 99%

An overview of glomerular filtration rate testing in dogs and cats

Hendy-Willson

Pressler

2011

The Veterinary Journal

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“…In human and animal clinical treatment, tramadol has a relatively lower incidence of addiction and is considered a safe analgesic for the treatment of moderate to severe pain [2,[5][6][7][8]. In addition, tramadol is also used to reduce the anaesthetic requirements [9,10].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats

Jang

Lee

2010

Korean J Physiol Pharmacol

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ABBREVIATIONS: EEG, electroencephalogram; TFL, tail-flick latency; NSS, numerical seizure score; %MPE, a percentage of maximal possible effect; MPF, median power frequency; SEF95, spectral edge frequency 95; SWD, spike-wave discharge.Received May 31, 2010, Revised June 10, 2010, Accepted June 20, 2010 Corresponding to: Maan-Gee Lee, Department of Pharmacology, School of Medicine, Kyungpook National University, 2-101, Dongindong, The effects of different doses of tramadol on analgesia and electroencephalographic (EEG) spectral parameters were compared in rats. Saline or tramadol 5, 10, 20 or 40 mg/kg was administered. The degree of analgesia was evaluated by tail-flick latency, and the degree of seizure was measured using numerical seizure score (NSS). Additionally, band powers, median power frequency and spectral edge frequency 95 were measured to quantify the EEG response. All doses of tramadol produced spike-wave discharge. Tramadol significantly and dose-dependently increased the analgesia, but these effects did not correspond with the changes in the EEG spectral parameters. NSS significantly increased in the Tramadol 20 and 40 mg/kg treatment groups compared to the Control and TRA5 groups, and two rats given 40 mg/kg had convulsions. In conclusion, tramadol dose-dependently increased the analgesic effect, and the 10 mg/kg dose appears to be a reliable clinical dose for analgesia in rats, but dose-dependent increases in analgesia and seizure severity did not correlate with EEG spectral parameters.

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“…Tramadol is a centrally acting analgesic that is structurally related to codeine and morphine (Shilo et al 2008). It acts as a weak m-opioid agonist coupled with inhibition of synaptic reuptake of serotonin and norepinephrine, achieving spinal modulation of pain and preventing impulses reaching the brain (Kongara et al 2009). It had been used in several species, including cats (De et al 2008;Paulo et al 2008).…”

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Effects of tramadol with tiletamine/zolazepam-xylazine as anaesthesia in cats

Dong

et al. 2013

Acta Vet. Brno

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This study was conducted to investigate the effect of the combination of tiletamine/zolazepamxylazine-tramadol (TZXT) in cats and to compare its efficacy as an anaesthetic technique with tiletamine/zolazepam-xylazine (TZX). Fourteen healthy thirteen-month-old cats of both sexes were immobilized by TZXT or TZX on two different occasions. The cats' scores for immobilization, analgesia and baseline physiological indicators, heart rate, respiratory rate and rectal temperature, were recorded before and 5, 10, 15, 20, 30, 40, 50, 60, 80, 100 and 120 min after administration of TZXT or TZX. Animals in both groups became laterally recumbent within 3 min and physiological indicators changed after administration. These changes were within biologically acceptable limits; these measurements did not differ between the treatments. Induction and recovery quality in animals was better with TZXT than with TZX. Sedation, analgesia, muscle relaxation and posture scores was higher in TZXT group. During recovery, cats in TZXT group were more conscious than cats in TZX group. This study showed that in cats, addition of tramadol (T) to TZX improved the quality of anaesthetic induction and increased the analgesic effect without adversely affecting the physiological indicators. Thus tiletamine/ zolazepam-xylazine-tramadol shows to be more suitable for cat anaesthesia.

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Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs

Cited by 28 publications

References 43 publications

An overview of glomerular filtration rate testing in dogs and cats

An overview of glomerular filtration rate testing in dogs and cats

The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats

Effects of tramadol with tiletamine/zolazepam-xylazine as anaesthesia in cats

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