The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats

Jang, Hee‐Seong; Jang, Il‐Sung; Lee, Maan‐Gee

doi:10.4196/kjpp.2010.14.3.191

Cited by 8 publications

(3 citation statements)

References 34 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings revealed that abnormalities in the EEG were affected by dosage, duration of consumption, and the time interval between consumption and the occurrence of seizures. Although we did not have a comparable human article, animal studies show that tra-madol can cause seizures at all doses (26). Our study also had some limitations.…”

Section: Discussionmentioning

confidence: 84%

Tramadol Abuse-associated Seizure: An Epidemiological and Electroencephalographic Study

Iranmanesh

Arvan

Ahmadipour

et al. 2023

Int J High Risk Behav Addict

View full text Add to dashboard Cite

Background: Seizure is one of the most severe side effects of tramadol abuse that can be irreversible. Objectives: This study aimed to investigate the frequency of tramadol abuse-associated seizure and electroencephalogram findings in patients with seizures. Methods: This cross-sectional study was conducted on patients with generalized tonic-clonic seizures caused by tramadol abuse. After history examination and systemic and neurologic evaluation, patients with abnormality in the neurological examination, metabolic evaluation, or non-contrast CT scan were excluded. Electroencephalography was performed between the third and fifth days. Demographic data and electroencephalograph findings were recorded and analyzed. Results: A total of 356 patients with seizures were enrolled, and tramadol abuse-associated seizure was the initial diagnosis in 12.9% of the patients. Among them, 9.3% had tramadol abuse seizures, which followed the study protocol completely. Abnormal electroencephalography was found in 48.5% of the patients, and epileptic discharges were observed in 21.2% of them. The consumed amount of tramadol, the duration of consumption, and the time interval between the consumption of tramadol and the onset of seizure were associated with electroencephalogram abnormality. Conclusions: Tramadol abuse-associated seizures occurred in a significant number of the patients. Half of the patients had electroencephalogram abnormalities.

show abstract

Section: Discussionmentioning

confidence: 84%

Tramadol Abuse-associated Seizure: An Epidemiological and Electroencephalographic Study

Iranmanesh

Arvan

Ahmadipour

et al. 2023

Int J High Risk Behav Addict

View full text Add to dashboard Cite

show abstract

“…Neurotransmitter concentrations were measured in the frontal cortex, the main area of serotoninergic projections that exhibited the prominent number of spike-wave discharges after 10 to 40 mg/kg tramadol administration [ 63 ]. Following tramadol administration, rats were immediately placed for 10 min in an anesthesia induction chamber (Tem Sega, Pessac, France) with 4% isoflurane (Virbac, Carros, France).…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

et al. 2022

View full text Add to dashboard Cite

Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study’s aim was to identify the mechanisms involved in tramadol-induced seizures in overdose in rats. The investigations included (1) the effects of specific pretreatments on tramadol-induced seizure onset and brain monoamine concentrations, (2) the interaction between tramadol and γ-aminobutyric acid (GABA)A receptors in vivo in the brain using positron emission tomography (PET) imaging and 11C-flumazenil. Diazepam abolished tramadol-induced seizures, in contrast to naloxone, cyproheptadine and fexofenadine pretreatments. Despite seizure abolishment, diazepam significantly enhanced tramadol-induced increase in the brain serotonin (p < 0.01), histamine (p < 0.01), dopamine (p < 0.05) and norepinephrine (p < 0.05). No displacement of 11C-flumazenil brain kinetics was observed following tramadol administration in contrast to diazepam, suggesting that the observed interaction was not related to a competitive mechanism between tramadol and flumazenil at the benzodiazepine-binding site. Our findings do not support the involvement of serotoninergic, histaminergic, dopaminergic, norepinephrine or opioidergic pathways in tramadol-induced seizures in overdose, but they strongly suggest a tramadol-induced allosteric change of the benzodiazepine-binding site of GABAA receptors. Management of tramadol-poisoned patients should take into account that tramadol-induced seizures are mainly related to a GABAergic pathway.

show abstract

“…However, sedation was the side effect observed at a higher dose and no side effect at lower dose 17 . In our study we have taken a dose of 10 mg/kg 18 – 21 , as very lower dose of tramadol is not potent to relieve the pain in rats whereas higher dose of tramadol may induce sedation 17 and increased NSS (numerical seizure score) 19 . It has been seen that, during both at active and resting phase administration of tramadol in drinking water resulted in stable plasma concentration in mice 22 .…”

Section: Introductionmentioning

confidence: 99%

Post craniotomy pain management in Copenhagen rat by intraperitoneal or oral dosage of Tramadol: a comparative evaluation

Samal,

Barik,

Jena

2023

Sci Rep

View full text Add to dashboard Cite

Calvarial craniotomy in animal models involves pain and distress. Moderate to severe pain in laboratory animals requires adequate pain management strategies. According to previous studies, the options available for suitable analgesia for rat calvarial craniotomy are very few. For most analgesic treatments, injectable routes of administration are predominantly used. However, these routes require restraining the animals, which may cause unnecessary pain, distress and suffering. As a well-fare measure, we focused on pain management by oral administration of analgesia. In this particular study, which is a sub-study of a major experiment on bone regeneration with different polymeric scaffold materials, we have compared the analgesic efficacy of intraperitoneal (I/P) and oral administration of tramadol (10 mg/kg) over a period of 96 h post-surgery in rat craniotomy models. The focus of our study is to evaluate the potential pain reduction efficacy of orally administered Tramadol without any restraining involved. We have used various non-invasive methods to assess the pain-alleviating efficacy of tramadol administered through different methods. We found that the efficacy of oral administration of tramadol is comparable to I/P administration in alleviating pain. Additionally, oral administration through drinking water has the benefit of not putting the animal under unwanted restraining stress.

show abstract

The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats

Cited by 8 publications

References 34 publications

Tramadol Abuse-associated Seizure: An Epidemiological and Electroencephalographic Study

Tramadol Abuse-associated Seizure: An Epidemiological and Electroencephalographic Study

Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

Post craniotomy pain management in Copenhagen rat by intraperitoneal or oral dosage of Tramadol: a comparative evaluation

Contact Info

Product

Resources

About