Global human genetics of HIV-1 infection and China

Zhu, Tuo Fu; Feng, Tie Jian; Xiao, Xiangning; Wang, Hui; Zhou, Baoyuan

doi:10.1038/sj.cr.7290355

Cited by 3 publications

(3 citation statements)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This allele results in a truncated protein of CCR5, which is retained in the endoplasmic reticulum instead of being expressed on the cell surface, subsequently blocking the entry of HIV-1 to the cells (Benkirane et al, 1997;Meyer et al, 1997;Michael et al, 1997;Theodorou et al, 1997;Venkatesan et al, 2002). Compared with the high frequency of 0.1 of CCR5-D32 allele in Caucasians, it is extremely low in Asians and Africans, indicating genetic heterogeneity of HIV-1 infection in different races (Galvani and Novembre, 2005;Zhu et al, 2005). A HIV-1-infected person with acute myeloid leukemia was transplanted with allogeneic CCR5-D32 +/+ homozygous stem cells and showed successful reconstitution of CD4 + T cells at the systemic level without any evidence of HIV-1 infection for more than 3.5 years after discontinuation of antiretroviral therapy (Allers et al, 2011).…”

Section: Introductionmentioning

confidence: 95%

A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

Gong

Liu

et al. 2015

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 95%

A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

Gong

Liu

et al. 2015

Infection, Genetics and Evolution

View full text Add to dashboard Cite

“…Interestingly, a study on one patient showed that HIV-1 infected patient treated with CCR5 Δ32/Δ32 stem cell transplantation reconstituted CD4 + T cell and remained without viral rebound after treatment [8,9]. However, a survey in a Chinese population found no homozygous CCR5 Δ32 individuals, and only about 0.36% (5 of 1406) were carriers of the CCR5 Δ32 allele [10,11]. Other CCR5 alleles and one CCR2 variant have shown varying levels of association with risk of HIV transmission and disease progression [12].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort

Zhu

Zhang

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

There is considerable variability between individuals in susceptibility to infection by human immunodeficiency virus (HIV). Many social, clinical and genetic factors are known to contribute to the likelihood of HIV transmission, but there is little consensus on the relative importance and potential interaction of these factors. Additionally, recent studies of several variants in chemokine receptors have identified alleles that may be predictive of HIV transmission and disease progression; however the strengths and directions of the associations of these genetic markers with HIV transmission have markedly varied between studies. To better identify factors that predict HIV transmission in a Chinese population, 180 cohabiting serodiscordant couples were enrolled for study by the Henan Center for Disease Prevention and Control, and transmission and progression of HIV infection were regularly measured. We found that anti-retroviral therapy, education level, and condom use were the most significant factors in determining likelihood of HIV transmission in this study. We also assessed ten variants in three genes (CXCL12, CCR2, and CCR5) that have been shown to influence HIV transmission. We found two tightly linked variants in CCR2 and CCR5, rs1799864 and rs1800024, have a significant positive association with transmission as recessive models (OR>10, P value=0.011). Mixed effects models showed that these genetic variants both retained significance when assessed with either treatment or condom use. These markers of transmission susceptibility may therefore serve to help stratify individuals by risk for HIV transmission.

show abstract

“…Despite multiple sexual exposures, some individuals remain seronegative, whereas some infected individuals become symptomatic within 2-3 years while others remain asymptomatic for more than 10-15 years [Fauci, 1996;Fauci et al, 1996;O'Brien et al, 2000]. Studies in the past few years have demonstrated that innate immunity including genetic polymorphism in host genes can affect the risk of HIV-1 infection and disease progression, although the effect of these alleles has been inconsistent [Zhu et al, 2005]. Evidence of strong epidemiological associations between cytokines and HIV disease progression has been limited and in some cases inconsistent across studies [Marmor et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Association of IL‐4 589 C/T promoter and IL‐4RαI50V receptor polymorphism with susceptibility to HIV‐1 infection in North Indians

Chatterjee

Rathore

Dhole

2009

Journal of Medical Virology

View full text Add to dashboard Cite

The clinical course and outcome of HIV-1 infection are highly variable among individuals. Interleukin 4 (IL-4) is a key T helper 2 cytokine with various immune-modulating functions including induction of immunoglobulin E (IgE) production in B cells, downregulation of CCR5 and upregulation of CXCR4, the main co-receptors for HIV. Our objective is to investigate whether single-nucleotide polymorphisms (SNPs) in the IL-4 promoter 589 C/T and IL-4 Ralpha I50V affect the susceptibility to HIV infection and its progression to AIDS in North Indian individuals. The study population consisted of 180 HIV-1 seropositive (HSP) stratified on the basis of disease severity (stage I, II, III), 50 HIV-1 exposed seronegative (HES), and 305 HIV-1 seronegative (HSN) individuals. The subjects were genotyped for IL-4 589 C/T promoter polymorphism and IL-4 Ralpha I50V by polymerase chain reaction restriction fragment length polymorphism. The results showed that IL-4 589 C/T was not associated with the risk of HIV infection and disease progression. However, the IL-4Ralpha I50 allele and genotype was significantly increased in HSP compared to HSN and HSP and was associated with risk of HIV infection. The frequency of IL-4Ralpha I50 allele in the HSP group was higher than in HSN (76.11 vs. 64.75%; P = 0.000; OR = 1.734) and HES (76.11% vs. 62.00%; P = 0.007; OR = 1.953). Homozygous IL-4Ralpha I50I genotype was significantly increased in HSP group compared with HSN (58.88% vs. 44.26%; P = 0.002; OR = 1.804) and HES (58.88% vs. 42.00%; P = 0.038; OR = 1.978). The present study for the first time suggests an association of IL-4Ralpha I50 allele with increased likelihood of HIV-1 infection in North Indian population. Further studies are required to confirm these findings and understand the effect of IL-4Ralpha polymorphism on the outcome of HIV-1 infection.

show abstract

Global human genetics of HIV-1 infection and China

Cited by 3 publications

References 131 publications

A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort

Association of IL‐4 589 C/T promoter and IL‐4RαI50V receptor polymorphism with susceptibility to HIV‐1 infection in North Indians

Contact Info

Product

Resources

About