2015
DOI: 10.1371/journal.pone.0129979
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Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort

Abstract: There is considerable variability between individuals in susceptibility to infection by human immunodeficiency virus (HIV). Many social, clinical and genetic factors are known to contribute to the likelihood of HIV transmission, but there is little consensus on the relative importance and potential interaction of these factors. Additionally, recent studies of several variants in chemokine receptors have identified alleles that may be predictive of HIV transmission and disease progression; however the strengths… Show more

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Cited by 5 publications
(5 citation statements)
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“… [31] Moreover, the most interesting agreement with the literature is the synergy between CCR2 rs1799864_814 and CCR5 rs1800024, both located on chromosome 3. Mutations in CCR2 rs1799864 and CCR5 rs1800024 were found to predict HIV transmission, [32] but nothing has been described in relation to immune recovery status until now. The multiple SNP analysis showed a high LD between CCR2 rs1799864_814 and CCR5 rs1800024, and the expression of the CCR2 rs1799864_814 AG genotype was significantly related to increased plasma RANTES concentrations in INR participants.…”
Section: Discussionmentioning
confidence: 99%
“… [31] Moreover, the most interesting agreement with the literature is the synergy between CCR2 rs1799864_814 and CCR5 rs1800024, both located on chromosome 3. Mutations in CCR2 rs1799864 and CCR5 rs1800024 were found to predict HIV transmission, [32] but nothing has been described in relation to immune recovery status until now. The multiple SNP analysis showed a high LD between CCR2 rs1799864_814 and CCR5 rs1800024, and the expression of the CCR2 rs1799864_814 AG genotype was significantly related to increased plasma RANTES concentrations in INR participants.…”
Section: Discussionmentioning
confidence: 99%
“…Various sociobehavioral factors along with biological, genetic, and immunological factors play a role in the risk of transmission between discordant couples. 9 Transmission among SDCs ranges from 5.0 to 16.7 per 100 person years. 1 The annual risk of transmission from an HIV-infected partner to an HIV-uninfected partner in a discordant state is around 20-25%.…”
Section: Discussionmentioning
confidence: 99%
“…[ 27 ] Rs1800024 in CCR5 is located on intron2 region and tightly linked to CCR2 rs1799864 for predicting HIV transmission. [ 28 ] Unfortunately, these polymorphisms are rarely studied for their association with PV development.…”
Section: Discussionmentioning
confidence: 99%