A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

Gong, Xiaohong; Liu, Yanyan; Liu, Feng-Liang; Jin, Li; Wang, Hongyan; Zheng, Yong‐Tang

doi:10.1016/j.meegid.2015.07.012

Cited by 4 publications

(4 citation statements)

References 41 publications

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“…After reviewing the title, abstract and the full paper, 23 studies were enrolled for meta-analysis. 16 studies were found to fulfill the eligibility criteria for the current meta-analysis with susceptibility to HIV infection including 2803 patients and 3697 healthy controls [ 2 , 4 , 5 , 7 , 8 , 10 , 12 – 22 ]. 7 studies were found to fulfill the eligibility criteria for the association analysis of SDF1 polymorphism and AIDS progression including 4239 HIV-infected patients [ 23 – 31 ].…”

Section: Resultsmentioning

confidence: 99%

Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis

et al. 2018

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ObjectivesGenetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies.MethodsArticles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017. Data were pooled by odds ratios (ORs) for HIV-1 infection with 95% confidence intervals (CIs) and summary relative hazards (RHs) for AIDS progression with 95% CIs using 1987 Center for Disease Control (CDC) case definition of AIDS (CDC87) and 1993 Center for Disease Control (CDC) case definition of AIDS (CDC93) and death as endpoints.ResultsAs a result, 16 studies regarding susceptibility to HIV-1 infection with 2803 HIV-infected patients and 3697 healthy individuals and 7 studies regarding disease progression with 4239 subjects were included in the meta-analysis. For risks of infection, no evidences indicated SDF1 polymorphism was associated with the risk of HIV-1 infection in all genetic models (recessive model: OR = 0.94, 95% Cl: 0.75–1.17; homozygous model: OR = 0.89, 95% Cl: 0.70–1.15; heterozygous model: OR = 1.06, 95% Cl: 0.83–1.35; allele model: OR = 0.95, 95% Cl: 0.79–1.13), Furthermore, we failed to find an delayed AIDS progression except in some specific cohorts including MACS cohorts (RH = 0.38, 95% Cl: 0.17–0.59 for time to AIDS; RH = 0.27, 95% Cl: 0.07–0.46 for time to death at the study entry).ConclusionsOverall, no significant association was found between SDF1 polymorphism and HIV susceptibility. A protective effect of SDF1 on AIDS progression and death was seen especially in two studies based on the same cohorts. In conclusion, SDF1 polymorphism exerts a moderate protective effect against AIDS disease deterioration in some specific populations.

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Section: Resultsmentioning

confidence: 99%

Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis

et al. 2018

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“…Furthermore, no statistical significance could be observed for SNPs and Indels in this review for: rs1800024, rs2856758, rs2734648, rs1799987 in Japanese population; 38 rs2734648, rs1799987, rs1799988, rs1800023, rs1800024 in Indian population; 63 Δ32 in Colombian population; 60 Δ32 in Nigerian population; 65 Δ32 in Iranian population; 66 rs2856758, rs2734648, rs41469351, rs1800023, rs1800024 in Malawi population; 49 Δ32 in another Indian population; 46 Δ32 in another U.S. population; 43 rs2856758, rs2734648, rs1799988, rs41469351, rs1800023, rs1800024 in populations of Papua New Guinea, the United States, Senegal, Guinea, Sierra Leone, Ivory Coast, and Ghana; 64 Δ32 in another Indian population; 39 rs184370729, rs1800024, Δ32 in Brazilian population; 44 Δ32 in Cameroon population; 59 rs2734225, rs1799988, rs1800452, rs746492 in Chinese population; 62 Δ32 in another Iranian population. 68 …”

Section: Discussionmentioning

confidence: 99%

The Influence Between C-C Chemokine Receptor 5 Genetic Polymorphisms and the Type-1 Human Immunodeficiency Virus: A 20-Year Review

Santana

Silva

Marin

et al. 2023

AIDS Research and Human Retroviruses

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Acquired immune deficiency syndrome (AIDS) is an infectious disease caused by the types 1 and 2 human immunodeficiency virus (HIV-1 and HIV-2). Clinical outcomes in patients are highly varied and delineated by complex interactions between virus, host, and environment, such as with help of co-receptors, for example, the C-C chemokine receptor 5 (CCR5). This work aimed to describe the scientific evidence relating the influence of CCR5 polymorphisms in association studies for HIV-1 disease susceptibility, severity, and transmissibility. This is a systematic review of the literature on single nucleotide polymorphisms (SNPs) and the deletion [Insertion and Deletion (Indel)] Δ32 of CCR5 . The search for articles was based on the ScienceDirect, PubMed, and Coordination for the Improvement of Higher Education Personnel (CAPES) databases for the period between 2001 and 2021. The final sample consisted of 32 articles. Correction: This article has been updated on December 22, 2022 after first online publication of November 9, 2022 to clarify two sentences in the Abstract: † This phrase formerly read: “The SNP rs1799987 is the genetic polymorphism most associated with HIV-1 susceptibility and severity criteria,”. ‡ This sentence formerly read: “Furthermore, the results about the Indel Δ32 corroborate the non-association of this variant with the protective role in HIV-1 infection.” SNP rs1799987 is one of the genetic polymorphisms most associated with the criteria of susceptibility and severity of HIV-1, having distinct consequences in genotypic, allelic, and clinical analysis in the variability of investigated populations. As for the transmission character of the disease, the G mutant allele of rs1799987 corresponds to the highest positive association. Correction: This article has been updated on December 22, 2022 after first online publication of November 9, 2022 to clarify two sentences in the Abstract: † This phrase formerly read: “The SNP rs1799987 is the genetic polymorphism most associated with HIV-1 susceptibility and severity criteria,”. ‡ This sentence formerly read: “Furthermore, the results about the Indel Δ32 corroborate the non-association of this variant with the protective role in HIV-1 infection.” Furthermore, the results on Indel Δ32 corroborate the absence and rarity of this variant in some populations. Finally, mitigating the severity of cases, SNPs rs1799988 and rs1800023 obtained significant attribution in individuals in the studied populations. It is shown that the reported polymorphisms express significant influences for the evaluation of diagnostic, therapeutic, and prophylactic measures for HIV-1 having fundamental particularities in the molecular, genetic, and transcriptional aspects of CCR5 .

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“…Apparently, Asians and Africans with CCL5-403A/A genotype (chemotactic chemokine ligand 5), also called RANTES (regulated on activation, normal, T cell expressed and secreted), could be resistant to HIV-1 but controlled studies are still lacking to confirm this observation [ 50 ]. In China, a genetic variant of SDF-1, the primary ligand of CXCR4 ((C-X-C motif) receptor 4), was associated with resistance to HIV infection in intravenous drug users [ 51 ].…”

Section: Genes and Susceptibility To Hiv Infectionmentioning

confidence: 99%

Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections

Assone

Paiva²,

Fonseca

et al. 2016

Viruses

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Human T-cell leukemia virus type 1 (HTLV-1), hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) are prevalent worldwide, and share similar means of transmission. These infections may influence each other in evolution and outcome, including cancer or immunodeficiency. Many studies have reported the influence of genetic markers on the host immune response against different persistent viral infections, such as HTLV-1 infection, pointing to the importance of the individual genetic background on their outcomes. However, despite recent advances on the knowledge of the pathogenesis of HTLV-1 infection, gaps in the understanding of the role of the individual genetic background on the progress to disease clinically manifested still remain. In this scenario, much less is known regarding the influence of genetic factors in the context of dual or triple infections or their influence on the underlying mechanisms that lead to outcomes that differ from those observed in monoinfection. This review describes the main factors involved in the virus–host balance, especially for some particular human leukocyte antigen (HLA) haplotypes, and other important genetic markers in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other persistent viruses, such as HIV and HCV.

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A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China

Cited by 4 publications

References 41 publications

Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis

Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis

The Influence Between C-C Chemokine Receptor 5 Genetic Polymorphisms and the Type-1 Human Immunodeficiency Virus: A 20-Year Review

Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections

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