Association of gene polymorphism of SDF1(CXCR12) with susceptibility to HIV-1 infection and AIDS disease progression: A meta-analysis

Abstract

ObjectivesGenetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies.MethodsArticles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017. Data were pooled by odds ratios (ORs) for HIV-1 infection with 95% confidence intervals (CIs) and summary relative hazards (RHs) for AIDS progression with 95% CIs using 1987 Center for Disease Control (CDC) case definition of AIDS (CDC87) and 1993 Center for Disease Control (CDC) case definition of AIDS (CDC93) and death as endpoints.ResultsAs a result, 16 studies regarding susceptibility to HIV-1 infection with 2803 HIV-infected patients and 3697 healthy individuals and 7 studies regarding disease progression with 4239 subjects were included in the meta-analysis. For risks of infection, no evidences indicated SDF1 polymorphism was associated with the risk of HIV-1 infection in all genetic models (recessive model: OR = 0.94, 95% Cl: 0.75–1.17; homozygous model: OR = 0.89, 95% Cl: 0.70–1.15; heterozygous model: OR = 1.06, 95% Cl: 0.83–1.35; allele model: OR = 0.95, 95% Cl: 0.79–1.13), Furthermore, we failed to find an delayed AIDS progression except in some specific cohorts including MACS cohorts (RH = 0.38, 95% Cl: 0.17–0.59 for time to AIDS; RH = 0.27, 95% Cl: 0.07–0.46 for time to death at the study entry).ConclusionsOverall, no significant association was found between SDF1 polymorphism and HIV susceptibility. A protective effect of SDF1 on AIDS progression and death was seen especially in two studies based on the same cohorts. In conclusion, SDF1 polymorphism exerts a moderate protective effect against AIDS disease deterioration in some specific populations.

Hematopoietic Stem/Progenitor Cells and the Pathogenesis of HIV/AIDS

“…The polymorphisms of SDF-1 might affect the ability to prevent HIV-1 infection (Winkler et al, 1998;Kuipers et al, 1999). However, the effect of SDF-1 polymorphisms on the susceptibility of the host to HIV-1 infection might be moderate (Ding et al, 2018). In contrast to the popularity of the topics of CXCR4 as an HIV-1 coreceptor and SDF-1 as an inhibitor of HIV-1 infection (Arenzana-Seisdedos, 2015), relatively few articles have addressed the intrinsic functions of SDF-1 and CXCR4 in the pathogenesis of HIV-1 infection and AIDS (Ikegawa et al, 2001;Tsukamoto, 2018).…”

Treatment with Antiviral Drugs Will Significantly Inhibit the HIV-1 RNA POL Gene Expression and Viral Load in AIDS Patients

“…Monotherapy quickly leads to the emergence of resistant strains and treatment failure due to the high mutation rate of the HIV genome during viral replication. Inhibition of many different enzymes and blocking of important host-virus interactions during the virus life cycle are the key to completely blocking viral replication and preventing the development of drug resistance [7].…”

Study of gene polymorphism for stromal cell-derived factor 1 (SDF1/ XCL12) and its elevation in plasma of women of reproductive age with pelvic inflammatory diseases in Babylon province

“…(38) reported that these genotypes showed no significant difference in the levels of the SDF-1α and β mRNA,so suggested that SDF-1α and SDF-1β may act as tumor markers as well as no alteration of the ratio of SDF-1 β mRNA to SDF-1α mRNA . However, (39) and (40), demonstrated no clear association between SDF-1α and β mRNA expression and SDF-1-3 ' A genotype in normal donors, but significantly excessive SDF-1 expression in HIV-1 infected children with SDF-1-3 ' A polymorphism compared to those with SDF-1-wild-type. Their finding was comparable to this result that SDF-1-3 ' A polymorphism was associated with the elevated CXCL12-α expression in patients with PID.…”