Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries

Sing, Chor‐Wing; Lin, Tzu‐Chieh; Bartholomew, Sharon; Bell, J. Simon; Bennett, Corina; Beyene, Kebede; Bosco‐Lévy, Pauline; Chan, Amy Hai Yan; Chandran, Manju; Cheung, Ching‐Lung; Doyon, Caroline Y.; Droz–Perroteau, C.; Ganesan, Ganga; Hartikainen, Sirpa; Ilomäki, Jenni; Jeong, Han Eol; Kiel, Douglas P.; Kubota, Kiyoshi; Lai, Edward Chia‐Cheng; Lange, Jeffrey L.; Lewiecki, E. Michael; Liu, Jiannong; Man, Kenneth K C; Abreu, Mirhelen Mendes de; Moore, Nicholas; O’Kelly, James; Ooba, Nobuhiro; Pedersen, Alma B; Prieto‐Alhambra, Daniel; Shin, Ju‐Young; Sørensen, Henrik Toft; Tan, Kelvin Bryan; Tolppanen, Anna‐Maija; Verhamme, Katia; Wang, Grace Hsin-Min; Watcharathanakij, Sawaeng; Zhao, Hong; Wong, Ian C. K.

doi:10.1136/bmjopen-2020-047258

Cited by 22 publications

(14 citation statements)

References 26 publications

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“…An estimated 2.6 million individuals will suffer a hip fracture by the year 2025, and 7 to 21 million by 2050 [2] . The morbidity associated with hip fracture is high, with 30 to 50% of patients losing functional independence, and mortality is such that it has been called the last fracture of life [3] . Within one year after hip fracture surgery mortality is as high as 30% (21% in the United States, and 17.9% in Asia) [4] .…”

Section: Introductionmentioning

confidence: 99%

Prognostic nomogram for risk of mortality after hip fracture surgery in geriatrics

Pan¹,

Ning²,

Wu³

et al. 2022

Injury

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Hip fracture is a significant public health problem, with associated high morbidity and mortality. Orthopedic surgeons are concerned to improve prognosis and stratify mortality risk after hip fracture surgery. This study established a nomogram that combines the Charlson Comorbidity Index (CCI) with specific laboratory parameters to predict mortality risk after hip fracture surgery in geriatrics. Methods: The records of consecutive patients who underwent hip fracture surgery from January 2015 through May 2020 at one medical center were reviewed for perioperative factors and mortality. Patients with age ≥ 70 years who were diagnosed with intertrochanteric or femoral neck fractures were included. Patients who were diagnosed with pathological fracture, received only conservative treatment or lost to follow-up were excluded. A multivariate Cox proportional hazards regression model was used to identify risk factors. A nomogram was established with R software and evaluated using concordance (C)-index, area under receiver operating characteristic (AUC), calibration curves, and decision curve analysis (DCA). Results: In total, 454 patients were included with a mean age of 81.6 years. The mean follow-up and oneyear mortality rate were 37.2 months and 10.4%, respectively. Five identified risk variables for mortality after hip fracture surgery in geriatrics comprised age (HR 1.05, 95% CI 1.01-1.08; P = 0.003), CCI (HR 1.38, 95% CI 1.24-1.54; P = 0.0 0 0), albumin (HR 1.78, 95% CI 1.31-2.43; P = 0.0 0 0), sodium (HR 1.59, 95% CI 1.18-2.15; P = 0.002) and hemoglobin (HR 1.46, 95% CI 1.07-2.00; P = 0.02). A nomogram was proposed and evaluated, showing a C-index of 0.76 ± 0.02. The AUCs for 6-month, 1-year, and 3-year mortality predictions were 0.83, 0.79, and 0.77, respectively. The calibration curve and DCA showed good discrimination and clinical usefulness. Conclusion: This novel nomogram for stratifying the mortality risk after hip fracture surgery in geriatrics incorporated age, CCI, serum albumin, sodium, and hemoglobin. Internal validation indicated that the model has good accuracy and usefulness. This nomogram had improved convenience and precision compared with other models. External validation is warranted to confirm its performance.

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Section: Introductionmentioning

confidence: 99%

Prognostic nomogram for risk of mortality after hip fracture surgery in geriatrics

Pan¹,

Ning²,

Wu³

et al. 2022

Injury

View full text Add to dashboard Cite

show abstract

“…Between 1986 and 2005, the annual mean number of hip fractures has been reported in the United States as 957.3 per 100,000 for women and 414.44 per 100,000 for men [1]. However, there is wide variation in incidence of hip fracture in the 50 years and older patient grouping world-wide [2].…”

Section: Hip Fracturementioning

confidence: 99%

Hip Fracture As A Potential Contributor To Cognitive Decline And Dementia

Thompson¹

2022

Neuro Neurosci

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This paper reviews the possible link between hip fracture and cognitive decline and dementia. There is a growing body of clinical research literature that indicates that cognitive decline is associated with the presence of delirium and that delirium is a predictor of dementia. Hip fracture is thought to be an independent factor that may lead to cognitive decline and dementia. It is suggested that cost implications should not become an obstacle to determining the best course of rehabilitation when delirium signals the need for preventive measures to protect the welfare of patients with hip fracture.

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“…Hip fracture in the elderly is a common problem worldwide. In many developed societies, the incidence of hip fractures is expected to increase over years in aging population 1. Patients with hip fractures often have significant pain, particularly with movement 2.…”

Section: Introductionmentioning

confidence: 99%

Pericapsular nerve group (PENG) block for early pain management of elderly patients with hip fracture: a single-center double-blind randomized controlled trial

Lin

Liu

Goh

et al. 2023

Reg Anesth Pain Med

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BackgroundThe pericapsular nerve group block (PENG) is a novel technique that blocks the articular branches of the hip joint. This study aimed to compare its effectiveness to a sham block in elderly patients with hip fractures.MethodA randomized double-blind controlled trial was conducted in elderly patients with intertrochanteric and neck of femur fractures. Patients were randomized to receive either PENG block or a sham block. Postblock, systemic analgesia was titrated using a standardized protocol of acetaminophen, oral morphine or patient-controlled analgesia. The primary outcome was the dynamic pain score (Numerical Rating Scale 0–10) at 30 min postblock. Secondary outcomes included pain scores at multiple other time points and 24-hour opioid consumption.Results60 patients were randomized and 57 completed the trial (PENG n=28, control n=29). Patients in PENG group had significantly lower dynamic pain scores at 30 min compared with control group (median (IQR) 3 (0.5–5) vs 5 (3–10), p<0.01). For the secondary outcomes, dynamic pain scores were lower in PENG group at 1 hour (median (IQR) 2 (1–3.25) vs 5 (3–8), p<0.01) and 3 hours postblock (median (IQR) 2 (0–5) vs 5 (2–8), p<0.05). Patients in PENG group had lower 24-hour opioid consumption (median (IQR) oral morphine equivalent dose 10 (0–15) vs 15 (10–30) mg, p<0.05).ConclusionPENG block provided effective analgesia for acute traumatic pain following hip fracture. Further studies are required to validate the superiority of PENG blocks over other regional techniques.Trial registration numberNCT04996979.

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Global epidemiology of hip fractures: a study protocol using a common analytical platform among multiple countries

Cited by 22 publications

References 26 publications

Prognostic nomogram for risk of mortality after hip fracture surgery in geriatrics

Prognostic nomogram for risk of mortality after hip fracture surgery in geriatrics

Hip Fracture As A Potential Contributor To Cognitive Decline And Dementia

Pericapsular nerve group (PENG) block for early pain management of elderly patients with hip fracture: a single-center double-blind randomized controlled trial

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