Glioblastoma of the cerebellum. Computed tomographic and pathologic considerations

Cerebellar Glioblastoma Multiforme in an Adult

“…Solid tumors with contrast enhancement or those with central hypodensity suggesting necrosis were described in cerebellar GBM. Occhiogrosso et al 16) found little peritumoral edema in patients with cerebellar GBM, and Zito et al 23) stated that CT was helpful in differentiating GBM from metastasis of the cerebellum via peritumoral edema or mass effect. The use of MRI has increased the accuracy of the definition of the nature of the lesion because of its good tissue resolution and lack of major bone artifacts 2,5) .…”

Primary cerebellar glioblastoma multiforme

“…All published reports of adult cerebellar glioblastomas were reviewed [1,[3][4][5][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. The criteria for selection of our patients included: a) 16 years of age or older, b) published histopathology of a Grade III or IV cerebellar glioma without significant brainstem involvement (that would suggest primary brainstem origin), c) the cerebellum was the primary location of the glioblastoma multiforme, d) no previous history of a lower grade or benign juvenile cerebellar astrocytoma, and e) no previous history of metastatic disease to the cerebellum.…”

Multicentric Cerebellopontine Angle Glioblastoma Multiforme

“…The outcome following the diagnosis of a cerebellar GBM is very poor with very short survival in spite of all forms of therapy [1, 3,6,7,8,9,12,13,14,15], althoughHegedus et al [5] reported a significantly long survival in a case of cerebellar GBM. The outcome is further worsened by the increased tendency of leptomeningeal metastases by CSF dissemination in pediatric patients as compared to adults [16, 18, 19].…”

“…The reason for the rarity of GBM in the cerebellum is undefined. Since the review of primary cerebellar glioblastomas in 1975 by Dohrmann and Dunsmore [4], very few cases of primary cerebellar GBM have been reported in the literature [1,5,6,7,8,9,12,13,14,15]. Most of these patients presented with symptoms of cerebellar involvement along with headache and vomiting [5, 7, 12].…”

“…Primary cerebellar GBM is a rare tumor in children with only few truly documented cases reported in the literature [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Posterior fossa astrocytomas are the predominant glial neoplasm seen in children most of which are benign low-grade astrocytomas and have a very good prognosis [16].…”