Cerebellar Glioblastoma Multiforme in an Adult

Hur, Hyuk; Jung, Shin; Jung, Tae‐Young; Kim, In-Young

doi:10.3340/jkns.2008.43.4.194

Cited by 29 publications

(31 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relative cerebral blood volumes choline levels in the peritumoural areas calculated with perfussion-weighted MR imaging and MR-spectroscopy are clearly higher in gliomas than in metastases. Inspite of primary or metastatic tumours, GB could be seen high signal intensity on diffusion-weighted MR images and decreased centrally signal intensity on ADC map [2]. The biological behavior of posterior fossa and supratentorial GB is similar.…”

Section: Case Reportmentioning

confidence: 91%

“…GBs located in posterior fossa are not yet completely understood for their pathogenesis and prognosis due to their rarity [2]. Here we report a posterior fossa GB in an adult patient.…”

Section: Introductionmentioning

confidence: 88%

“…They also concluded that the lost of the entire chromosome 10, no TP53 mutation and EGFR/ PTEN/Akt/ mTor signaling pathway is typical for primary glioblastomas [1,3]. There is no apparent reason why these tumours rarely occur in the cerebellum and posterior fossa [2]. Although our patient's immunohistochemical findings were not enough to demonstrate the tumour subset, we have thought that her tumour was de novo because of no other brain involvement, staining with GFAP, vimentin, and nearly abscent p53 mutation.…”

Section: Case Reportmentioning

confidence: 99%

“…Although our patient's immunohistochemical findings were not enough to demonstrate the tumour subset, we have thought that her tumour was de novo because of no other brain involvement, staining with GFAP, vimentin, and nearly abscent p53 mutation. Although the development of GB following pilocytic astrocytoma, medulloblastoma and other poste- rior fossa midline tumours has been described [2], this description of this transformation could be difficult by possibility to anaplastic astrocytic evolution of those cells. On the other hand there is controversy concerning the primary origin of GB or secondary anaplastic change from diffuse astrocytomas to GB.…”

Section: Case Reportmentioning

confidence: 99%

“…The biological behavior of posterior fossa and supratentorial GB is similar. The median survival for this tumour is approximately 19 months [2]. In literature, it has been suggested that achievement of the complete tumour extirpation increases the survival especially in patients with recurrent high grade gliomas.…”

Section: Case Reportmentioning

confidence: 99%

See 4 more Smart Citations

Glioblastoma Located in Posterior Fossa

Bakar¹,

Yazici²,

Kose³

et al. 2013

Ann Clin Anal Med

View full text Add to dashboard Cite

ÖzetSekiz ay önce posterior fossa yerleşimli glioblastoma (GB) tümörü nedeni ile opere edilmiş 63 yaşında kadın hasta baş ağrısı, stupor, bulantı ve kusma şikayetleri ile acil servise getirildi. Çekilen beyin BT ve MR tetkiklerinde posterior fossada kistik-nekrotik görünümlü tümör nüksü tespit edildi. Tümör ameliyatla tama yakın çıkarıldı. Ancak operasyon yerinde dirençli beyin omurilik suyu (BOS) fistülü oluştu ve daha sonra çoklu antibiyotik drenci olan Acinetobacter baumanii tarafından enfekte edildi. İki ay sonra hasta septisemiden kaybedildi. Posterior fossa yerleşimli GB, yetişkin ve çocukta oldukça nadir olup iki farklı şekilde ortaya çıkar:de novo (primer tip) ve sekonder GB. Her ne kadar bizim hastamızın tümör alt tipini immunhistokimyasal olarak yeterince aydınlatılamasa da hastadaki tümö-rün beyinde başka tutulum alanının olmaması, GFAP, vimentin gibi boyalarla güçlü boyanması ancak p53 mutasyonunun olmaması gibi nedenlerle de novo kökenli olduğu düşünüldü. Anahtar KelimelerGlioblastoma; De Novo; Fistül; Menenjit. AbstractA 63-year-old woman operated eight months ago for glioblastoma (GB) located in posterior fossa was admitted to emergency room for stuporous, nausea, vomiting and headache. CT and MR showed recurrence of posterior fossa cysticnecrotic tumour without any other intracranial contrast enhancing lesion. Tumour was removed near totally. Perseverative cerebrospinal fluid (CSF) fistula from the incision was occurred and contaminated by multidrug resistant Acinetobacter baumannii. Two months after the tumour removal she was expired because of the septicaemia. GB located in posterior fossa is uncommon in both adults and children; and it appears as two different subsets: de novo (primary type) and secondary glioblastomas. Although our patient's immunohistochemical findings werenot enough to demonstrate the tumour subset, we have thought that her tumour was de novo because of no other brain involvement, staining with GFAP, vimentin, and nearly absent p53 mutation.

show abstract

Section: Case Reportmentioning

confidence: 91%

“…GBs located in posterior fossa are not yet completely understood for their pathogenesis and prognosis due to their rarity [2]. Here we report a posterior fossa GB in an adult patient.…”

Section: Introductionmentioning

confidence: 88%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 3 more Smart Citations

Glioblastoma Located in Posterior Fossa

Bakar¹,

Yazici²,

Kose³

et al. 2013

Ann Clin Anal Med

View full text Add to dashboard Cite

show abstract

Anything but Little: a Pictorial Review on Anatomy and Pathology of the Cerebellum

2023

View full text Add to dashboard Cite

Characteristics of cerebellar glioblastomas in adults

et al. 2017

View full text Add to dashboard Cite

Adult cerebellar glioblastomas (cGBM) are rare and their characteristics remain to be fully described. We analyzed the characteristics of 17 adult patients with cGBM and compared them to a series of 103 patients presenting a supra-tentorial glioblastoma (stGBM). The mean age at GBMc diagnosis was 53.4 years (range 28-77). A history of neurofibromatosis type I was noted in 3 patients. cGBM were hemispheric in 10 patients (58.8%), only vermian in 4 patients (23.5%), and both vermian and hemispheric in 3 patients (17.7%). A H3 K27M mutation was identified in 3/14 patients, a TERT promoter mutation in 3/14 patients and a methylated MGMT promoter in 3/14 patients. None of the patients (0/14) harbored an EGFR amplification, an IDH or a BRAF mutation. Association with neurofibromatosis type I and H3K27M mutations were mutually exclusive. Compared with stGBM, cGBM occurred in younger patients (53.4 vs. 63.2, p = 0.02), were more frequently associated with neurofibromatosis type I (18 vs. 1%, p = 0.009) and with a H3 K27M mutation (21 vs. 3%, p = 0.02). They also tended to have a more frequent multifocal presentation at diagnosis (21 vs. 4.3%, p = 0.06), more frequently resulted in leptomeningeal or intra-axial metastasis (44.5 vs. 5%, p = 0.002) and were associated with a shorter median overall survival (5.9 vs. 14.2 months, p = 0.004). The present study suggests that adult cGBM differ from their supra-tentorial counterpart and constitute a heterogeneous group of IDH wild-type gliomas with at least two subgroups, one associated with H3K27M mutations and the other with neurofibromatosis type I.

show abstract

Cerebellar Glioblastoma Multiforme in an Adult

Cited by 29 publications

References 16 publications

Glioblastoma Located in Posterior Fossa

Glioblastoma Located in Posterior Fossa

Anything but Little: a Pictorial Review on Anatomy and Pathology of the Cerebellum

Characteristics of cerebellar glioblastomas in adults

Contact Info

Product

Resources

About