Multicentric Cerebellopontine Angle Glioblastoma Multiforme

Kasliwal, Manish K.; Gupta, Deepak K.; Mahapatra, Ashok Kumar; Sharma, Mehar Chand

doi:10.1159/000121380

Cited by 17 publications

(21 citation statements)

References 19 publications

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“…However primary GBM arising in the CPA is further rare with a few reported cases1,2,5–7,9–11). To our knowledge, six cases have been reported in the literatures2,5–7,9,10). Table 1 summarizes the cases of primary GBMs in the CPA.…”

Section: Discussionmentioning

confidence: 99%

“…The first category of the CPA glioblastoma is an intraaxial tumor originated from brain stem or cerebellum with an exophytic growth into the CPA4–7,9,11). This type of GBM is rare, and especially cerebellar GBM with the exophytic growth pattern is very rare, and up to date, four cases have been reported in the literature2,4,5,11). Two cases showed exophytic growth into CPA, and the other two cases were in the crural/quadrigeminal cistern and cisterna magna, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Primary infratentorial GBM is an uncommon disease in adults and rarely found in cerebellopontine angle (CPA), especially8,10). A few cases of GBM arising in CPA have been reported in the literature1,2,5–7,9,11). Most of cases reported are primary intraaxial GBM arising from cerebellar hemisphere or brainstem, with exophytic extension into CPA.…”

Section: Introductionmentioning

confidence: 99%

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Primary Glioblastoma of the Cerebellopontine Angle : Case Report and Review of the Literature

Lee

Kim

Kwon

2017

J Korean Neurosurg Soc

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Glioblastoma multiforme (GBM) is located most frequently in the cerebral hemispheres. Glioblastoma presenting as an extraaxial mass of cerebellopontine angle (CPA) is very rare in adults. We report a rare case of GBM arising in the CPA. The patient was a 71-year-old female, who complained of progressive gait disturbance and poor memory. Initial magnetic resonance imaging (MRI) revealed a 1.4×1.3 cm mass in the left CPA, with broad base to the petrous bone, showing homogenous enhancement. Follow-up MRI showed a rapid increase in size of mass (2.7×2.2 cm) with a necrotic portion. A stereotactic biopsy was done under the guidance of navigation system, and the histopathologic diagnosis was GBM, World Heath Organization grade IV. Further surgical resection was not performed considering her general condition, and the patient underwent concurrent chemotherapy with radiation therapy. Although rare, the possibility of glioblastoma should be included in the differential diagnosis of atypical CPA tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Glioblastoma of the Cerebellopontine Angle : Case Report and Review of the Literature

Lee

Kim

Kwon

2017

J Korean Neurosurg Soc

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“…We searched PubMed and Google Scholar and found only two English-language articles reporting the coexistence of multiple lesions and a CPA lesion [13, 14]. According to the literature, CPA glioblastomas may have different origins [15].…”

Section: Discussionmentioning

confidence: 99%

Progressive multifocal exophytic pontine glioblastoma: a case report with literature review

Chen

Weng

et al. 2017

Chin J Cancer

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Multifocal pontine glioblastoma exhibiting an exophytic growth pattern in the cerebello-pontine angle (CPA) is rare. We present a case of a 5-year-old girl with consecutive neurological imaging and other clinical findings indicating progressive multifocal exophytic pontine glioblastoma. Three lesions were reported, of which two were initially presented, and one was developed 2 months later. One lesion demonstrated a progressing exophytic extension in the cistern of the left side of the CPA. The other two lesions were located and confined within the pons. Initial magnetic resonance imaging and positron emission tomography–computed tomography indicated low-grade glioma or inflammatory disease. However, 2 and 3 months later, subsequent magnetic resonance spectroscopy (MRS) displayed elevated choline and depressed N-acetyl aspartate peaks compared with the peaks on the initial MRS, indicating a high-grade glioma. Subtotal resection was performed for the CPA lesion. Histopathologic examination showed discrepant features of different parts of the CPA lesion. The patient received no further chemotherapy or radiotherapy and died 2 months after surgery. The multifocal and exophytic features of this case and the heterogeneous manifestations on neurological images were rare and confusing for both diagnosis and surgical decision-making. Our case report may contribute knowledge and helpful guidance for other medical doctors.

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“…In addition, malignant primary CPA gliomas had also been described so far. Breshears et al [7] and Kasliwal et al [23] described a case of a primary glioblastoma multiforme (GBM) of the trigeminal nerve root entry zone and primary GBM of the oculomotor nerve [34,45], and the VIII cranial nerve [47] had also been reported.…”

Section: Primary Cpa Gliomamentioning

confidence: 99%

Surgical management of primary and secondary pilocytic astrocytoma of the cerebellopontine angle (in adults and children) and review of the literature

et al. 2020

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Glial tumors in the cerebellopontine angle (CPA) are uncommon and comprise less than 1% of CPA tumors. We present four cases of pilocytic astrocytoma of the CPA (PA-CPA) that were treated in our department. Patients who received surgical treatment for PA-CPA from January 2004 to December 2019 were identified by a computer search of their files from the Department of Neurosurgery, Tübingen. Patients were evaluated for initial symptoms, pre-and postoperative facial nerve function and cochlear function, complications, and recurrence rate by reviewing surgical reports, patient documents, neuroradiological data, and follow-up data. We identified four patients with PA-CPA out of about 1500 CPA lesions (~0.2%), which were surgically treated in our department in the last 16 years. Of the four patients, three were male, and one was a female patient. Two were adults, and two were children (mean age 35 years). A gross total resection was achieved in three cases, and a subtotal resection was attained in one case. Two patients experienced a moderate facial palsy immediately after surgery (House-Brackmann grade III). In all cases, the facial function was intact or good (House-Brackmann grades I-II) at the long-term follow-up (mean follow-up 4.5 years). No mortality occurred during follow-up. Three of the patients had no recurrence at the latest follow-up (mean latest follow-up 4.5 years), while one patient had a slight recurrence. PA-CPA can be safely removed, and most complications immediately after surgery resolve in the long-term follow-up.

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Multicentric Cerebellopontine Angle Glioblastoma Multiforme

Cited by 17 publications

References 19 publications

Primary Glioblastoma of the Cerebellopontine Angle : Case Report and Review of the Literature

Primary Glioblastoma of the Cerebellopontine Angle : Case Report and Review of the Literature

Progressive multifocal exophytic pontine glioblastoma: a case report with literature review

Surgical management of primary and secondary pilocytic astrocytoma of the cerebellopontine angle (in adults and children) and review of the literature

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