GLC Analysis of Multicomponent Suppository Formulations

Cometti, A.; Bagnasco, G.; Maggi, N

doi:10.1002/jps.2600600717

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…Previous studies established the need for assay methods that are sufficiently sensitive to measure -2 ng of drug/ml of serum (1,2), a fact that contributed to the paucity of pharmacokinetic data. Although several analytical procedures are available to measure chlorpheniramine (1,2,(5)(6)(7)(8)(9)(10), most of the methods were developed to assay the drug in dosage forms or in urine; only a few of these methods have the necessary sensitivity to measure normal serum levels throughout a kinetic investigation.…”

Section: Introductionmentioning

confidence: 99%

Sensitive GLC–mass spectrometric determination of chlorpheniramine in serum

Thompson

Leffert

1980

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Sensitive GLC–mass spectrometric determination of chlorpheniramine in serum

Thompson

Leffert

1980

Journal of Pharmaceutical Sciences

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“…Cometti and coworkers (54) recently reported on gas chromatographic analysis of multicomponent suppositories. Depending on the composition of the vehicle, absolute ethanol, chloroform or a mixture of chloroform and alcohol-containing internal standards is added to the melted suppository to dissolve the sample.…”

mentioning

confidence: 99%

Analysis of oil‐based pharmaceuticals

Smith

1972

J Americ Oil Chem Soc

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Oils of animal, mineral and vegetable origin are used in the formulation of pharmaceuticals. In most cases the analysis of these pharmaceuticals requires the separation of the drug substance from the oil components prior to its quantitation, the required degree of separation depending on the specificity of the quantitation method. When the physical properties of the drug substance are quite similar to those of components of the oil, the separation of the drug becomes complex. Column partition chromatography provides an excellent means of separating steroids from the vegetable oil vehicles used in injectables. Both reverse phase and direct phase techniques are applied to the separation of the steroids from the glyceride, stern and triterpenoid fractions of the oil. Illustrations are provided to demonstrate the application of thin layer chromatography, paper chromatography, gas chromatography, gel permeation chromatography and adsorption chromatography in the analysis of oil solutions, oil-based dermatological preparations and suppositories.

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