Analysis of oil‐based pharmaceuticals

Abstract

Oils of animal, mineral and vegetable origin are used in the formulation of pharmaceuticals. In most cases the analysis of these pharmaceuticals requires the separation of the drug substance from the oil components prior to its quantitation, the required degree of separation depending on the specificity of the quantitation method. When the physical properties of the drug substance are quite similar to those of components of the oil, the separation of the drug becomes complex. Column partition chromatography provides an excellent means of separating steroids from the vegetable oil vehicles used in injectables. Both reverse phase and direct phase techniques are applied to the separation of the steroids from the glyceride, stern and triterpenoid fractions of the oil. Illustrations are provided to demonstrate the application of thin layer chromatography, paper chromatography, gas chromatography, gel permeation chromatography and adsorption chromatography in the analysis of oil solutions, oil-based dermatological preparations and suppositories.

Stability-Indicating Analysis of Injectable Estrogen-Androgen Combinations in Formulations Containing Corn Oil

“…Drug determination in formulations containing vegetable oil usually requires separation of the drug substances from the oil components prior to quantitation (2)(3)(4)(5)(6). The added requirement that the method be stability indicating can add to the procedural complexity.…”

Progesterone Injection Assay by Liquid Chromatography

“…Analytical approaches to drugs in oil-based pharmaceuticals (2) and the pharmaceutical aspects of high-pressure liquid chromatography (HPLC) (3) have been reviewed. Specific, but cumbersome, progesterone determinations have been advanced including an IR partition column assay (4) and an extraction method followed by GLC (5).…”

Διεργασίες Μεταφοράς Ηλεκτρονίων Σε Νανο - Υβριδικά Υλικά

“…Οι μεταλλο-φκαλοκυανίνεσ εξαιτίασ τθσ δομισ τουσ και του πλικουσ των μετάλλων που μποροφν να ενςωματϊςουν ςτο κζντρο του φκαλοκυανικοφ τουσ δακτυλίου, ζχουν βρει πλικοσ εφαρμογϊν ςτθ βιομθχανία κυρίωσσ ωσ χρωςτικζσ 218,[220][221][222] , ωσ υγρά κρυςτάλλων 223,224 , ωσ θλεκτροκαταλφτεσ 225 , ωσ αιςκθτιρεσ 226 , ςε θλεκτροχρωμικζσ οκόνεσ 227,228 , ςτθν οπτοθλεκτρονικι 229 , ςτα φωτοβολταϊκά 230 και ςτθ φωτοδυναμικι κεραπεία (PDT) 231 ακόμθ και ςτθν θλεκτροκατάλυςθ 225 .…”