Sensitive GLC–mass spectrometric determination of chlorpheniramine in serum

Thompson, John A.; Leffert, Fred

doi:10.1002/jps.2600690626

Cited by 26 publications

(8 citation statements)

References 10 publications

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“…Only four research teams (O'Brien et al , ; Giachetti et al , ; Hattori et al , ; Nishikawa et al , ) managed to determine simultaneously different antihistamines along with other drugs in biological samples using NPD or FID. MS detection by chemical ionization (CI) (Fouda et al ., ; Kageura et al , ; Seno et al , ) and electron impact‐selected ion monitoring (EI‐SIM) (Kintz et al , ; Thompson and Leffert, ; Seno et al , ; Tonn et al , ; Martens, ; Hasegawa et al , ; Pujadas et al , ) have also been used for the determination of antihistamines after GC separation. These methods gave satisfactory results concerning the LODs (Table ).…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

“…These methods gave satisfactory results concerning the LODs (Table ). The analyzed antihistamines were screened and quantitated using scan (Maurer and Pfleger, ; Seno et al , ) or SIM (Kintz et al, ; Fouda et al , ; Thompson and Leffert, ; Kageura et al , ; Tonn et al , ; Martens, ; Hasegawa et al , ; Pujadas et al , ) mode.…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

“…Nitrogenselective FID LOD = 10 60 10-5000 Thioridazine (external standard) Thompson and Leffert (1980)…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

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Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

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Antihistamines are a class of drugs that inhibit the action of histamine and are used to alleviate symptoms associated with allergic reactions, but some of them can cause side effects, the most unpleasant and dangerous of which are the sedative effects that may hinder important psychological functions and impair skilled performance. These side effects could decrease safety in certain common and critical tasks, such as driving or operating machinery, leading to accidents. Antihistamines can also cause intoxications, sometimes lethal, especially when co-administered with alcohol or other sedative drugs. Thus, the development of analytical methods for their determination in biological fluids is considered to be useful for the investigation of clinical and forensic cases. These methodologies could also be used for pharmacokinetic studies. Several liquid and a few gas chromatographic methods have been developed for the determination of antihistamines in biological matrices after proper pretreatment procedures. This article reviews the published analytical methodologies that were gathered through the search in PubMed database and the recent developments on isolation or determination of antihistamines in biological materials. Current trends and future perspectives on bioanalysis of antihistamines are also discussed. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Chromatographic Techniquesmentioning

confidence: 99%

Section: Chromatographic Techniquesmentioning

confidence: 99%

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Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

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“…The tetrabromophenolphthalein ethyl ester indicator is a monoprotic acid and can form ion associates or charge transfer complexes with amines or alkaloids (8). The initial mixture of the amines…”

Section: Resultsmentioning

confidence: 99%

“…A highly sensitive assay procedure for chlorpheniramine was recently developed (8). The distribution and elimination of chlorpheniramine following intravenous administration of the drug to children were examined using this technique.…”

mentioning

confidence: 99%

Pharmacokinetics of Intravenous Chlorpheniramine in Children

Thompson¹,

Bloedow²,

Leffert³

1981

Journal of Pharmaceutical Sciences

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High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study

Peng

Chen

et al. 2018

Luminescence

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A highly sensitive and selective method of high performance liquid chromatography (HPLC) combined with resonance Rayleigh scattering (RRS) spectra was developed for the detection of three antihistamine drugs, including pyrilamine (PY), carbinoxamine (CAR) and tripelennamine (TRI). The three antihistamines were separated by a C18 column. The mobile phase contained 25% acetonitrile (ACN) and 75% phosphate buffered solution (pH 3.2) with the flow rate of 0.4 ml min . In medium of Britton-Robinson (BR) buffer solution (pH 4.6), the PY, CAR and TRI separated by HPLC and then reacted with Erythrosine B (EryB), forming 1:1 ion-association complexes, which led to significant signal enhancement of RRS spectra. The RRS spectra was detected at the wavelength λ =λ = 370 nm. The calibration curves of PY, CAR and TRI were linear in the range from 0.02 to 25 μg ml , and the detection limit [signal-to-noise ratio (S/N) = 3] were 3.38, 4.48 and 5.50 ng ml , respectively. In addition, under the optimum experiment condition, the reaction mechanism and the reasons for RRS enhancement were investigated in this work. The developed method was applied to the simultaneous detection of three antihistamines in water samples with satisfying results.

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Sensitive GLC–mass spectrometric determination of chlorpheniramine in serum

Cited by 26 publications

References 10 publications

Bioanalysis of antihistamines for clinical or forensic purposes

Bioanalysis of antihistamines for clinical or forensic purposes

Pharmacokinetics of Intravenous Chlorpheniramine in Children

High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study

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