Glass contamination in parenterally administered medication

Preston, Stan T.; Hegadoren, Kathy

doi:10.1111/j.1365-2648.2004.03195.x

Cited by 32 publications

(31 citation statements)

References 20 publications

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“…Filter needles can reduce or eliminate particles in medication administered parenterally [2, 4, 9]. Therefore, many authors and organizations have recommended the use of filter needles for parenteral injections [2–4, 9–16].…”

Section: Introductionmentioning

confidence: 99%

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Applying Theory to Understand and Modify Nurse Intention to Adhere to Recommendations regarding the Use of Filter Needles: An Intervention Mapping Approach

Cassista

Payne-Gagnon

Martel³

et al. 2014

Nursing Research and Practice

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The manipulation of glass ampoules involves risk of particle contamination of parenteral medication, and the use of filter needles has often been recommended in order to reduce the number of particles in these solutions. This study aims to develop a theory-based intervention to increase nurse intention to use filter needles according to clinical guideline recommendations produced by a large university medical centre in Quebec (Canada). Using the Intervention Mapping framework, we first identified the psychosocial determinants of nurse intention to use filter needles according to these recommendations. Second, we developed and implemented an intervention targeting nurses from five care units in order to increase their intention to adhere to recommendations on the use of filter needles. We also assessed nurse satisfaction with the intervention. In total, 270 nurses received the intervention and 169 completed the posttest questionnaire. The two determinants of intention, that is, attitude and perceived behavioral control, were significantly higher after the intervention, but only perceived behavioral control remained a predictor of intention. In general, nurses were highly satisfied with the intervention. This study provides support for the use of Intervention Mapping to develop, implement, and evaluate theory-based interventions in order to improve healthcare professional adherence to clinical recommendations.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, many authors and organizations have recommended the use of filter needles for parenteral injections [2–4, 9–16]. However, they are still not the norm in many settings [13], and nurses do not always adhere to clinical guidelines and recommendations regarding their use [14].…”

Section: Introductionmentioning

confidence: 99%

Applying Theory to Understand and Modify Nurse Intention to Adhere to Recommendations regarding the Use of Filter Needles: An Intervention Mapping Approach

Cassista

Payne-Gagnon

Martel³

et al. 2014

Nursing Research and Practice

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“…Injected glass particles can travel through the blood vessels to arrive at various organs, and cause inflammatory responses. They are known to cause blockages, embolism, tissue necrosis, and sepsis (Brewer and Dunning 1947; Shaw and Lyall 1985; Carbone-Traber and Shanks 1986; Preston and Hegadoren 2004). In spite of these risks, glass ampules are commonly used for injections.…”

Section: Introductionmentioning

confidence: 99%

The effect of different methods of intravenous injection on glass particle contamination from ampules

2016

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There have been many studies on glass particle contamination from glass ampules during the injection of glass ampules, but only the contamination from direct IV bolus injection has been measured. This research aimed to study the difference in glass particle contamination from ampules with different intravenous administration methods commonly used in clinical practice. Four methods were studied: IV bolus injection directly after immediate aspiration, IV bolus injection directly after 2 min’ delayed aspiration, IV bolus injection directly after aspiration with a filter needle, and side shooting to an infusion set with an in-line filter. 45 ampules per method for a total of 180 ampules were used. The number and length of glass particles were measured using a slide scanner. Aspiration was performed without specifically using a slow aspiration method. The longest glass particle was observed in the immediate aspiration group. The side shooting group showed the lowest maximum number of glass particles per ampule. The side shooting group also showed the smallest number of glass particles, but it was statistically insignificant. Using a filter needle syringe and 2 min’ delayed aspiration, which are frequently recommended to minimize contamination, may not be as effective as commonly believed, unless combined with a slow and low pressure aspiration method. Using a side shooting to an infusion set with an in-line filter may minimize glass particle contamination from ampules even without a slow and low pressure aspiration method, but more evidence from a larger study is needed.

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“…Other studies demonstrated the effectiveness of filter needles and in-line filters to reduce glass particle contamination [21,22]. Preston et al [23] recovered glass particles larger than 130 µm in size in 57 % of controlled injectable solutions. Additionally, Lye et al [18] identified an average of 0.22 glass particles per unit in more than 500 glass ampoules analyzed.…”

Section: Particles From Glass Containersmentioning

confidence: 99%

“…The injection of these particles into the patient is therefore a major risk. Preston et al [23] therefore Table 1: Regulation limits on sub-visible particle diameters and counts according to the 2.9.19 monograph of the EP [5].…”

Section: Particles From Glass Containersmentioning

confidence: 99%

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

Perez

Maiguy-Foinard

Barthélémy

et al. 2016

Pharmaceutical Technology in Hospital Pharmacy

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AbstractOne of the fundamental principles guiding the pharmaceutical quality of parenteral products is to prevent injecting contaminants from microbiological, chemical or physical sources. It is just as difficult to ensure the absence of chemical and particulate contaminants in injectable products as it is to weigh up the microbiological risk. The problem of particulate matter is mainly related to the preparing and administrating of injectable drugs rather than through the contamination of marketed products. Particulate contamination also arises

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Glass contamination in parenterally administered medication

Cited by 32 publications

References 20 publications

Applying Theory to Understand and Modify Nurse Intention to Adhere to Recommendations regarding the Use of Filter Needles: An Intervention Mapping Approach

Applying Theory to Understand and Modify Nurse Intention to Adhere to Recommendations regarding the Use of Filter Needles: An Intervention Mapping Approach

The effect of different methods of intravenous injection on glass particle contamination from ampules

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

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