The effect of different methods of intravenous injection on glass particle contamination from ampules

Abstract

There have been many studies on glass particle contamination from glass ampules during the injection of glass ampules, but only the contamination from direct IV bolus injection has been measured. This research aimed to study the difference in glass particle contamination from ampules with different intravenous administration methods commonly used in clinical practice. Four methods were studied: IV bolus injection directly after immediate aspiration, IV bolus injection directly after 2 min’ delayed aspiration, IV bolus injection directly after aspiration with a filter needle, and side shooting to an infusion set with an in-line filter. 45 ampules per method for a total of 180 ampules were used. The number and length of glass particles were measured using a slide scanner. Aspiration was performed without specifically using a slow aspiration method. The longest glass particle was observed in the immediate aspiration group. The side shooting group showed the lowest maximum number of glass particles per ampule. The side shooting group also showed the smallest number of glass particles, but it was statistically insignificant. Using a filter needle syringe and 2 min’ delayed aspiration, which are frequently recommended to minimize contamination, may not be as effective as commonly believed, unless combined with a slow and low pressure aspiration method. Using a side shooting to an infusion set with an in-line filter may minimize glass particle contamination from ampules even without a slow and low pressure aspiration method, but more evidence from a larger study is needed.

Parenteral İlaçlardaki Gizli Tehdit: Cam Partikül Kontaminasyonu

“…18 Parenteral ilaç uygulamalarında filtreli iğne kullanımı ile hastalarda cam partikül kontaminasyonuna bağlı gelişebilecek sağlık sorunlarını yaşama riski azaltılarak hasta güvenliği arttırılabilir. 15,19 Cam ampul formu ilaçların açılması esnasında partikül kontaminasyonunun geliştiğini ortaya koyan ve bu kontaminasyonun önlenmesinde filtreli iğne kullanımını öneren çeşitli çalışmalar mevcuttur. 7,20 Amerika Sağlık Sistemi Eczacılar Derneği ilaçların güvenli bir şekilde hazırlanması ile ilgili standartlarında tek dozlu cam ampullerin içindeki ilacın enjektöre aspire edilmesi için 5 µm filtre iğnesi kullanılması gerektiği bildirilmektedir.…”

Particulate Matter in Injectable Drugs: Evaluation of Risks to Patients

“…Sabon et al [20] showed that various types of aspirating techniques and ampoules have no effect on glass particle contamination. Other studies demonstrated the effectiveness of filter needles and in-line filters to reduce glass particle contamination [21,22]. Preston et al [23] recovered glass particles larger than 130 µm in size in 57 % of controlled injectable solutions.…”

Helyi érzéstelenítők antibakteriális hatása

“…Az üvegampullák kinyitásakor üvegrészecskék kerülnek a folyadékba. Ha nem tartjuk be maradéktalanul a higiéniás előírásokat, az üvegrészecskékkel baktériumok is kerülnek az oldatba [9]. Azok a gyógyszerek, amelyek támogatják a baktériumok növekedését, súlyos kórházi fertőzést okozhatnak [10], míg az antibakteriális hatásúakban elpusztulnak a kontaminált csírák [8,11,12].…”