Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway

Choi, Yoon-Hee; Yoon, Ji-Hae; Cha, Seon‐Woo; Lee, Seong-Gene

doi:10.1016/j.fitote.2011.05.005

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…G-Rh1 at the concentrations of 10 and 20 µM significantly attenuated the toxicity on SH-SY5Y cells exposed to 60 µM of sixhydroxydopamine. This was partially because of the reduction of ERK1/2 phosphorylation by G-Rh1 pretreatment, as could be seen in other cell lines such as HepG2, U87MG, U937, and THP-1 cells [21,23,30,40]. G-Rh1 increased the percentage of PC-12 cells with neurites compared to that of the control.…”

Section: Effect On Nervous Systemssupporting

confidence: 52%

“…In addition, G-Rh1 markedly suppressed the CXCL-10 expression in TNF-α-induced human promonocytic U937 cells, which may be related to the inactivation of the ERK1/2 signaling pathway [40]. In THP-1 cells, G-Rh1 did not only inactivate ERK1/2, but also attenuated the phosphorylation and activation of MAPK signaling, p38MAPK and JNK activation of PKB/Akt through lowering the expression of MCP-1 and CCR2, and deactivating integrins, the fibronectin receptor VLA-5 and CD29 [21]. Li et al [22] found that after long-term dexamethasone treatment in RAW264.7 cells, it also induced the activation of DUSP1, resulting in the downregulation of proinflammatory cytokines (IL-6, IL-17, MMP-1, TNF-α).…”

Section: Anticancer Effectsmentioning

confidence: 96%

“…This compound has been additionally reported to effectively stimulate the central nervous system and enhance mental acuity and intellectual performance [20]. Several studies have shown that G-Rh1 possesses neuroprotective effects, potential antineoplastic effects, and the ability to be adjuvant therapy in chronic inflammatory diseases to dexamethasone [21][22][23]. Nonetheless, there is no critically evaluated review of the pharmacological effects of G-Rh1 based on summarizing the current reliable evidence.…”

Section: Introductionmentioning

confidence: 99%

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2018

Planta Med

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Supporting information available online at http://www.thieme-connect.de/products ABSTR AC TGinsenoside Rh1 is one of major bioactive compounds extracted from red ginseng, which has been increasingly used for enhancing cognition and physical health worldwide. The objective of this study was to review the pharmacological effects of ginsenoside Rh1 in a systematic manner. We performed searches on eight electronic databases including MEDLINE (Pubmed), Scopus, Google Scholar, POPLINE, Global Health Library, Virtual Health Library, the System for Information on Grey Literature in Europe, and the New York Academy of Medicine Grey Literature Report to select the original research publications reporting the biological and pharmacological effects of ginsenoside Rh1 from in vitro and in vivo studies regardless of publication language and study design. Upon applying the inclusion and exclusion criteria, we included a total of 57 studies for our systemic review. Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system. The cytotoxic effects of ginsenoside Rh1 were dependent on different types of cell lines. Other pharmacological effects including estrogenic, enzymatic, anti-microorganism activities, and cardiovascular effects have been mentioned, but the results were considerably diverged. A higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenoside Rh1.

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Section: Effect On Nervous Systemssupporting

confidence: 52%

Section: Anticancer Effectsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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2018

Planta Med

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“…For monocyte migration to occur integrins must be activated to provide docking sites at the blood-epithelial cell barrier. 19,20 Interestingly, the AQ ginseng extract downregulated two integrins: integrin alpha 8 and integrin, beta-like 1. This would suggest that polysaccharides in ginseng may trigger an inflammatory response in differentiated preadipocytes, but simultaneously prevent macrophage adhesion; however, this can only be elucidated by using a co-culture experimental system.…”

mentioning

confidence: 99%

“…The regulation of adipocyte integrins may offer a partial explanation for the previously reported whole-body anti-inflammatory effects in mice and humans treated with various ginsenosides. 20,21 More importantly, it suggests further research is needed to determine if ginseng is stimulating a local inflammatory event in adipocytes or, alternatively, whether adipocytes are contributing to an overall systemic response.…”

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confidence: 99%

Unraveling the adipocyte inflammomodulatory pathways activated by North American ginseng

et al. 2012

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BACKGROUND: North American (NA) ginseng (Panax quinquefolius) is a popular natural health product (NHP) that has been demonstrated to regulate immune function, inflammatory processes and response to stress and fatigue. Recent evidence suggests that various extracts of NA ginseng may have different bioactivities because of distinct profiles of ginsenosides and polysaccharides. To date, the bioactive role of ginseng on adipocytes remains relatively unexplored. OBJECTIVE: The goal of this work was to study the extract-specific bioactivity of NA ginseng on differentiated preadipocyte gene expression and adipocytokine secretion. METHODS: In vitro differentiated 3T3-L1 preadipocytes were treated with 25 and 50 mg ml À 1 of either crude ethanol (EtOH) or aqueous (AQ) NA ginseng extracts, or polysaccharide and ginsenoside extracts isolated from the AQ extract. Global gene expression was studied with microarrays and the resulting data were analyzed with functional pathway analysis. Adipocytokine secretion was also measured in media. RESULTS: Pathway analysis indicated that the AQ extract, and in particular the polysaccharide extract, triggered a global inflammomodulatory response in differentiated preadipocytes. Specifically, the expression of Il-6 (interleukin 6), Ccl5 (chemokine (C-C motif) ligand 5), Nfkb (nuclear factor-kappaB) and Tnfa (tumor necrosis factor alpha) was increased. These effects were also reflected at the protein level through the increased secretion of IL-6 and CCL5. No effect was seen with the EtOH extract or ginsenoside extract. Using a specific toll-like receptor 4 (TLR4) inhibitor reduced the upregulation of inflammatory gene expression, indicating the relevance of this pathway for the signaling capacity of NA ginseng polysaccharides. CONCLUSION: This work emphasizes the distinct bioactivities of different ginseng extracts on differentiated preadipocyte signaling pathways, and highlights the importance of TLR4 for mediating the inflammomodulatory role of ginseng polysaccharides.

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Therapeutic Potential of Ginsenosides in Management of Atherosclerosis

Zhang

Wang

et al. 2015

Phytotherapies

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Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway

Cited by 28 publications

References 27 publications

Untitled

Untitled

Unraveling the adipocyte inflammomodulatory pathways activated by North American ginseng

Therapeutic Potential of Ginsenosides in Management of Atherosclerosis

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