Therapeutic Potential of Ginsenosides in Management of Atherosclerosis

Quantitative Characterization of Ginsenoside Biotransformation in Panax notoginseng Inflorescences and Leaves by Online Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry

“…Its roots have been widely used to prevent and treat hematological and cardiovascular diseases for more than 400 years. 1 The roots are the official medicinal parts recorded in Chinese Pharmacopoeia, and other parts, such as inflorescences and leaves, are commonly used as folk medicine and functional foods. 2 P. notoginseng inflorescences (PNI) and leaves (PNL) were approved to be the new food ingredients in Yunnan Province, China, 3 and PNI has been widely used for drinking as a flower tea.…”

Saponins as Modulators of the Blood Coagulation System and Perspectives Regarding Their Use in the Prevention of Venous Thromboembolic Incidents

“…In recent years, the structure, distribution, and pharmacological importance of saponins have been extensively analyzed, both as a pure compound and as an enriched crude plant extract. Literature data clearly indicate that these compounds have a high anticoagulant/antithrombotic potential that can be used in the prevention and treatment of thromboembolic disease; both in vitro and in vivo models have found steroidal and triterpenoid saponins isolated from various plants to have these properties [18,[79][80][81]. Xiong et al report that P. notoginseng root and rhizome (0.5-3.5 mg/mL) demonstrate anticoagulant activity in vitro [11].…”

“…Xiong et al report that P. notoginseng root and rhizome (0.5-3.5 mg/mL) demonstrate anticoagulant activity in vitro [11]. Zhang et al also note that saponins isolated from the roots and rhizomes of P. notoginseng may play an important function in treating cardiovascular diseases such as coronary heart diseases, cardiac arrhythmia and angina pectoris [79]. In addition, Dong et al found P. notoginseng saponins to protect human umbilical vein endothelial cells from H 2 O 2 -stimulated oxidative stress [14].…”

LC/MS Analysis of Saponin Fraction from the Leaves of Elaeagnus rhamnoides (L.) A. Nelson and Its Biological Properties in Different In Vitro Models

“…Oxidative stress is considered as one of the key mechanisms associated with human pathological processes, including cardiovascular diseases and cancers. Zhang et al [ 33 ] have described that saponins isolated from the roots and rhizomes of Panax notoginseng may play an important role in treating different cardiovascular diseases, including angina pectoris, coronary heart diseases, and arrhythmia cordis. Authors suggest that the main bioactive ingredients are dammarane triterpene saponins.…”