Ginkgo biloba extract protects against ionizing radiation-induced oxidative organ damage in rats

Şener, Göksel; Kabasakal, Levent; Atasoy, Beste Melek; Erzik, Can; Velioğlu-Öğünç, Ayliz; Çetınel, Şule; Gedik, Nursal; Yeğen, Berrak Ç.

doi:10.1016/j.phrs.2005.11.006

Cited by 52 publications

(35 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Gamma irradiation showed an increase in the level of serum AST, ALT and ALP activities indicative to the toxicity induced by radiation exposure (Table 4). These results are in agreement with those previously reported by Fiener et al [36]. The increase in serum levels of these enzymes may be due to alteration in the dynamic permeability of membranes by ionizing radiation, allowing leakage of biological active material out of the injured cell, which may be associated with cell death or injuries [37].…”

Section: Parameterssupporting

confidence: 93%

Effect of Gamma Ray on Reactive Oxygen Species at Experimental Animals

Km¹

2017

OMICS J Radiol

View full text Add to dashboard Cite

The present study was designed to investigate the oxidative stress, which is due to the effect of low doses of gamma irradiation. Animals were divided into 6 groups, where the first group kept as control group, while 2 nd , 3 rd , 4 th , 5 th and 6 th groups were exposed to gamma ray at 1.5 Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy once weekly for one month respectively. Rats were subjected to gamma radiation and nitric oxides (NO), superoxide dismutase (SOD), malondialdehyde, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and white blood cells (WBCs) were measured. SOD recorded highly significant decrease with percent change -22.7%, -25.01%, -55.01% -55.4% and -56.38% respectively in groups which were exposed to 1.5, 2, 2.5, 3 and 3.5 Gy. MDA serum level have a significant increase in groups which were exposed to successive doses of 1.5 Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively with percent change 25.7% , 41.8% 59.1% 65.6% 75.8% consequently as compared to control group. Nitric oxide serum level is markedly showed highly significant increase in rats exposed to successive dose of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively with percent change 59.69%, 74.17%, 87.1%, 120.1% and 130.6% consequently as compared to control group. ALT and AST recorded highly significant increase in rats exposure to successive doses of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively. On the other hand WBCs recorded highly significant decreased in rats exposed to successive dose of 1.5, Gy, 2 Gy, 2.5 Gy, 3 Gy and 3.5 Gy respectively. WBCs recorded percent change -26.11%, -32.3%, -47.8%, -50.1% and -53.6% respectively as compared to control group.

show abstract

Section: Parameterssupporting

confidence: 93%

Effect of Gamma Ray on Reactive Oxygen Species at Experimental Animals

Km¹

2017

OMICS J Radiol

View full text Add to dashboard Cite

show abstract

“…Thiol-based antioxidants also have protective effects in the radiation-induced lung injury and fibrosis, including NAC (143) and amifostine (211). A number of flavonoids have also been used successfully to attenuate radiation-induced lung injury and fibrosis, including curcumin (200) and Ginko biloba extracts (175).…”

Section: Radiation Antioxidants and Oxidative Stressmentioning

confidence: 99%

Antioxidants as Potential Therapeutics for Lung Fibrosis

Day

2008

Antioxidants & Redox Signaling

120

View full text Add to dashboard Cite

Interstitial lung disease encompasses a large group of chronic lung disorders associated with excessive tissue remodeling, scarring, and fibrosis. The evidence of a redox imbalance in lung fibrosis is substantial, and the rationale for testing antioxidants as potential new therapeutics for lung fibrosis is appealing. Current animal models of lung fibrosis have clear involvement of ROS in their pathogenesis. New classes of antioxidant agents divided into catalytic antioxidant mimetics and antioxidant scavengers are being developed. The catalytic antioxidant class is based on endogenous antioxidant enzymes and includes the manganese-containing macrocyclics, porphyrins, salens, and the non-metal-containing nitroxides. The antioxidant scavenging class is based on endogenous antioxidant molecules and includes the vitamin E analogues, thiols, lazaroids, and polyphenolic agents. Numerous studies have shown oxidative stress to be associated with many interstitial lung diseases and that these agents are effective in attenuating fibroproliferative responses in the lung of animals and humans.

show abstract

“…It was found that supplementation reduces the genotoxic damage induced by radiation, without compromising the clinical recovery of the patients (Dardano et al, 2007). Sener et al (2006) analyzed the same radioprotective effect in which the G. biloba extract reduced the oxidative damage induced by ionizing radiation and the level of DNA fragmentation in the ileum of rats supplemented for 15 days before exposure to radiation.…”

Section: Resultsmentioning

confidence: 99%