Research Article In vivo antimutagenic activity of the medicinal plants Pfaffia glomerata (Brazilian ginseng) and Ginkgo biloba.

Almeida, Igor Vivian de; Düsman, Elisângela; Mattge, Giselle Ivone; Toledo, Fernando; Reusing, A F; Vicentini, Verônica Elisa Pimenta

doi:10.4238/gmr16039785

Cited by 9 publications

(1 citation statement)

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“…Moreover, some reports showed that the hydroethanolic extract of P. glomerata roots exhibits anti‐inflammatory and analgesic activity similar to the effects observed for drugs such as nonsteroidal drug as indomethacin (Neto et al, ). Recent studies showed that P. glomerata have no cytotoxic or mutagenic potential, and they significantly reduce the percentage of chromosomal aberrations induced by the chemotherapy cyclophosphamide (Almeida et al, ). Further, Freitas et al () demonstrated that P. glomerata extract has cytoprotective effect of gastric mucosa by increasing the nitric oxide (NO), which was corroborated by the increased levels of endogenous NO followed by activation of the guanylate cyclase in P. glomerata ‐treated mice (Teixeira, Piccolil, Costa, Soares, & Silva‐Santos, ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the testis function of mice exposed in utero and during lactation to Pfaffia glomerata (Brazilian ginseng)

et al. 2019

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Pfaffia glomerata (Spreng.) Pedersen, popularly known as “Brazilian ginseng,” is used as medicinal plant in Brazil to treat inflammatory diseases in general. Previous studies showed that its extract increases the nitric oxide (NO) levels. Knowing that NO downregulates steroidogenesis and that alterations in the action/production of androgens during perinatal life could alter testis development, the present studies sought to investigate the reproductive toxicity of Pfaffia glomerata on male mice exposed to hydroalcoholic extract in utero and during lactation. The present study shows that P. glomerata extract does not alter body weight, tubular diameter and testis function in male mice. Although a reduction in the testis weight was observed in the animals that received the highest dose directly in early post‐natal life, our findings show clearly that P. glomerata may not act as an endocrine disruptor, and it is not an “antiandrogenic” compound that could lead to testicular dysgenesis syndrome.

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Section: Introductionmentioning

confidence: 99%