Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects

Esfahrood, Zeinab Rezaei; Yadegari, Zahra; Veysari, Setareh Kazemi; Kadkhodazadeh, Mahdi

doi:10.5125/jkaoms.2018.44.6.289

Cited by 14 publications

(26 citation statements)

References 18 publications

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“…The main findings regarding the marker levels in periodontitis and health as well as the correlation between marker levels and clinical parameters are shown in Table 2. SOST showed greater levels in the GCF, serum, and gingival tissues of periodontitis sites when compared to healthy sites in four studies 45,53,57,58 . In addition, a fifth study demonstrated that when generalized moderate and severe periodontitis was considered, SOST exhibited significantly higher amounts in the GCF of periodontitis sites 50 .…”

Section: Resultsmentioning

confidence: 91%

“…Five studies were conducted in China, 46,52,54,59,60 3 in the USA, 50,51,55 2 in India, 48,58 2 in Turkey, 45,47 and the others were from Brazil, 57 Chile, 49 Thailand, 56 and Iran 53 . The majority of the studies were case–control studies ( n = 12), 45,50–60 while randomized clinical trials and non‐randomized clinical interventional studies were also included. The total number of periodontitis patients in the test groups ranged from 11 to 44 (periodontitis group), whereas the control group included 5 to 29 periodontally healthy individuals (healthy group).…”

Section: Resultsmentioning

confidence: 99%

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Expression of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after non‐surgical periodontal treatment: A systematic review

Chatzopoulos

Koidou

Wolff

2022

J of Periodontal Research

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Periodontitis is a preventable and treatable multifactorial chronic inflammatory disease that can lead to irreversible periodontal destruction and tooth loss. Wnt signaling and its regulators play an important role in periodontal inflammation, destruction, regeneration, and reconstruction. This systematic review aimed at investigating the involvement of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after periodontal treatment. Electronic searches were carried out using MEDLINE/PubMed, EMBASE, and Cochrane Library databases in addition to hand searches. Studies having different designs assessing the levels of Wnt signaling antagonist and agonist levels in gingival crevicular fluid, serum, and tissue in patients diagnosed with periodontitis or gingivitis, compared with healthy individuals were included. In addition, studies compared these levels in periodontitis patients before and after non‐surgical periodontal therapy were also eligible. Sixteen studies met the eligibility criteria. Sclerostin (SOST) has been mainly investigated in the literature (8 publications). Sclerostin (5 studies), Wnt‐5a (2 studies), secreted frizzled‐related protein 1 (SFRP1) (3 studies), and β‐catenin (3 studies) show increased levels in periodontitis compared with periodontal health. Strong correlations between marker levels and periodontal clinical parameters were identified for SOST (5 studies), SFRP1 (2 studies), and β‐catenin (2 studies). SOST (3 studies) and SFRP1 (1 study) levels significantly decrease following non‐surgical periodontal treatment. The present systematic review demonstrated an association between Wnt signaling agonist and antagonist levels and periodontitis. Wnt agonists and antagonists may serve as valuable diagnostic and prognostic markers for periodontitis onset and progression. Further case–control and longitudinal studies should be conducted for different Wnt signaling agonists and antagonists.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Expression of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after non‐surgical periodontal treatment: A systematic review

Chatzopoulos

Koidou

Wolff

2022

J of Periodontal Research

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“…Treatment with anti-Sclerostin antibody enhances alveolar bone mass, leads to the formation of cellular cementum and increases alveolar bone deposition [ 11 , 35 ]. Data from clinical studies have shown that SOST is upregulated in periodontal tissues, saliva and GCF of chronic periodontitis patients when compared to healthy sites [ 36 , 37 , 38 , 39 ]. In the present study, although there was a trend towards higher Sclerostin amounts in the gingivitis sites ( p = 0.09), no significant differences were observed between periodontitis, gingivitis and healthy sites in periodontitis patients ( p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues

et al. 2021

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Background and Objectives: Wnt signaling leads to stimulation of osteoblasts and it reduces osteoclastogenesis and bone resorption via the regulation of the osteprotegrin and receptor activator of nuclear factor kappa-Β ligan (RANKL). Wnt signaling pathways are regulated by their physiological antagonists such as sclerostin (SOST) as well as WNT-5a. The aim of this study was to determine the total amount of Sclerostin and WNT-5a in the gingival crevicular fluid (GCF) in sites with a continuum from a healthy to diseased periodontium. Materials and Methods: In this cross-sectional study, a total of 20 patients with generalized periodontitis, 10 subjects with gingivitis as well as 14 individuals with a healthy periodontium were recruited upon clinical and radiographic periodontal examination. In patients diagnosed with periodontitis, GCF samples were collected from periodontitis, gingivitis and healthy sites, while gingivitis patients provided samples from gingivitis and healthy sites. In healthy patients, only healthy sites were sampled. Protein total amount of SOST and WNT-5a were quantified by sandwich enzyme-linked immunosorbent assay (ELISA). Results: A total of 108 GCF samples were collected from a total of 44 individuals. When all periodontitis (n = 51), gingivitis (n = 12) and healthy (n = 45) sites were analyzed regardless of the patient diagnosis, periodontitis sites demonstrated significantly elevated WNT-5a total amounts (p = 0.03) when compared to gingivitis sites. Gingivitis sites demonstrated a trend of more total SOST (p = 0.09) when compared to periodontitis and healthy sites. Within each patient diagnostic category, sites showed similar SOST and WNT-5a total amounts (p > 0.05). Conclusions: WNT-5a levels in GCF depend on the stage of periodontitis sites. SOST trended higher in the GCF of gingivitis sites but similar in chronic periodontitis and healthy sites. WNT-5a and SOST play a crucial role in periodontal tissue remodeling and depend on the inflammatory and osteoclastogenic activities.

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“…The sclerostin content in gingival crevicular fluid from chronic periodontitis patients markedly exceeds that of healthy subjects [ 52 ], and the protein levels of sclerostin and DKK1 in gingival biopsy tissue and serum are relatively increased [ 53 , 54 ]. In animal experiments, an increase in sclerostin-positive osteocytes within alveolar bone was linked to a decrease in bone formation in a mouse model of periodontitis [ 55 , 56 ]; in parallel, the administration of sclerostin- and DKK1-specific antibodies markedly improved alveolar bone volume and structure [ 57 , 58 ].…”

Section: The Altered Secretory Function Of Osteocytes In Periodontitimentioning

confidence: 99%

The roles of osteocytes in alveolar bone destruction in periodontitis

Huang

Xie

et al. 2020

J Transl Med

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Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis. Classically, bone cells, such as osteoclasts, osteoblasts and bone marrow stromal cells, are thought to dominate the development of bone destruction in periodontitis. Recently, osteocytes, the cells embedded in the mineral matrix, have gained attention. This review demonstrates the key contributing role of osteocytes in periodontitis, especially in alveolar bone loss. Osteocytes not only initiate physiological bone remodeling but also assist in inflammation-related changes in bone remodeling. The latest evidence suggests that osteocytes are involved in regulating bone anabolism and catabolism in the progression of periodontitis. The altered secretion of receptor activator of NF-κB ligand (RANKL), sclerostin and Dickkopf-related protein 1 (DKK1) by osteocytes affects the balance of bone resorption and formation and promotes bone loss. In addition, the accumulation of prematurely senescent and apoptotic osteocytes observed in alveolar bone may exacerbate local destruction. Based on their communication with the bloodstream, it is noteworthy that osteocytes may participate in the interaction between local periodontitis lesions and systemic diseases. Overall, further investigations of osteocytes may provide vital insights that improve our understanding of the pathophysiology of periodontitis.

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Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects

Cited by 14 publications

References 18 publications

Expression of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after non‐surgical periodontal treatment: A systematic review

Expression of Wnt signaling agonists and antagonists in periodontitis and healthy subjects, before and after non‐surgical periodontal treatment: A systematic review

WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues

The roles of osteocytes in alveolar bone destruction in periodontitis

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