Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor‐κB Ligand in Periodontitis

Ballı, Umut; Aydoğdu, Ahmet; Dede, Figen Öngöz; Türer, Çiğdem Coşkun; Güven, Berrak

doi:10.1902/jop.2015.150270

Cited by 42 publications

(58 citation statements)

References 50 publications

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“…The mRNA and protein levels of SOST were statistically significantly up‐regulated in the gingival tissue and serum samples of patients with chronic periodontitis when compared to periodontally healthy patients. Chronic periodontitis patients have also shown increased SOST levels in GCF in a prospective cohort study from Turkey, while non‐surgical periodontal therapy resulted in decreased levels which was related to clinical improvement of the periodontal status . Although the study of Balli et al also used GCF samples, it did not completely agree with our findings.…”

Section: Discussioncontrasting

confidence: 80%

Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

Chatzopoulos

Mansky

Lunos

et al. 2019

J of Periodontal Research

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Background and Objective Wnt signaling pathways regulate osteoblast differentiation and bone formation and are associated with inflammatory responses driven by innate and adaptive immunity via the NF‐κB pathway. The aim of this study was to compare the levels of sclerostin (SOST), WNT‐5a, and TNF‐α between chronic periodontitis and periodontally healthy sites and determine their value as diagnostic markers of chronic periodontitis. Material and Methods In a cross‐sectional assessment 25 chronic periodontitis cases and 25 periodontally healthy controls were selected upon clinical and radiographic periodontal evaluation. Gingival crevicular fluid (GCF) was collected cross‐sectionally from diseased and healthy sites in periodontitis patients and from healthy sites in each control subject. In a subgroup analysis, ten patients with generalized moderate and severe chronic periodontitis and ten generalized periodontally healthy individuals were included. The protein levels of SOST, WNT‐5a, and TNF‐α in GCF were measured by sandwich ELISA. The Shapiro‐Wilk test was utilized to assess the normality of the distribution and non‐parametric comparisons were performed. Results The protein levels of SOST were significantly higher in the generalized moderate and severe chronic periodontitis subgroup when compared to the generalized healthy (P = 0.002), while the WNT‐5a and TNF‐α GCF total amounts were similar (P > 0.05). Diseased sites in the periodontitis patients exhibited significantly higher total protein levels of WNT‐5a than in healthy sites (P = 0.017), whereas no differences were detected for SOST and TNF‐α (P > 0.05). The total protein levels of SOST, WNT‐5a, and TNF‐α in GCF were similar in periodontitis and non‐periodontitis patients (P > 0.05). Conclusions Sclerostin and WNT‐5a gingival protein levels demonstrated a high diagnostic value for generalized moderate and severe chronic periodontitis, while a low accuracy was detected for localized chronic periodontitis.

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Section: Discussioncontrasting

confidence: 80%

Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

Chatzopoulos

Mansky

Lunos

et al. 2019

J of Periodontal Research

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“…GCF concentration of OPG was lower in chronic periodontitis, but increased after periodontal phase I therapy, although not significantly (31). The RANKL/OPG ratio was also reported unchanged at 2, 3, and 4 months after periodontal therapy (33,34). In accordance with these studies, the RANKL value was not altered in any of the treatment periods in the healthy periodontitis group (group B).…”

Section: Discussionsupporting

confidence: 77%

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

et al. 2017

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“…Three hundred and fifty microliters of phosphate‐buffered saline (pH 7.4) was added to tubes with the sample strips. Concentrations of VEGF‐A,** TNF‐α, †† and endocan ‡‡ in GCF and serum were determined using a sandwich enzyme‐linked immunosorbent assay method according to the protocol provided by the manufacturer, as described previously 35 . Concentrations in GCF and serum samples were determined from standard curves.…”

Section: Methodsmentioning

confidence: 99%

Effect of Non‐Surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor‐A, and Tumor Necrosis Factor‐Alpha Levels

Türer

Durmuş

Ballı

et al. 2017

Journal of Periodontology

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Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin, and Receptor Activator of Nuclear Factor‐κB Ligand in Periodontitis

Abstract: The GCF sclerostin level may be more reliable than the RANKL/OPG ratio as a diagnostic and prognostic marker of periodontal disease and treatment outcome. Regulation of sclerostin levels may aid the development of new therapeutic strategies for the treatment of periodontal disease.

Cited by 42 publications

References 50 publications

Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

Effect of Non‐Surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor‐A, and Tumor Necrosis Factor‐Alpha Levels

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