Gingival Crevicular Fluid Leptin Levels in Periodontitis Patients With Long‐Term and Heavy Smoking

Bozkurt, Fatma Yeşim; Ay, Zühal Yetkin; Sütçü, Recep; Delibaş, Namık; Demirel, Reha

doi:10.1902/jop.2006.050277

Cited by 46 publications

(50 citation statements)

References 65 publications

(77 reference statements)

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“…16 Leptin is also involved in antiosteogenic effects by acting centrally on the hypothalamus. 17 Thus, leptin at high local concentrations protects the host from inflammation and infection and maintains bone levels.…”

Section: Introductionmentioning

confidence: 99%

Leptin Levels in Gingival Crevicular Fluid During Orthodontic Tooth Movement

Dilsiz¹,

Kılıç²,

Aydın³

et al. 2010

The Angle Orthodontist

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Objectives: To test if leptin can be detected in the gingival crevicular fluid (GCF) around moving teeth, and to determine whether any changes occur during orthodontic tooth movement. Materials and Methods: An upper canine requiring distal movement served as the test tooth; the contralateral canine was used as a control tooth. The control tooth was included in the orthodontic appliance, but was not subjected to the orthodontic force. GCF sampling from the distal sites of the test and control teeth was done at baseline, 1 hour, 24 hours, and 168 hours. Results: Leptin concentrations of the test teeth decreased in a time-dependent manner. When compared with the baseline measurement, the decrease was significant at 168 hours (P , .05). Conclusions:The concentration of leptin in GCF is decreased by orthodontic tooth movement; the results of the present study also suggest that leptin may have been one of the mediators responsible for orthodontic tooth movement. (Angle Orthod. 2010;80:504-508.)

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Section: Introductionmentioning

confidence: 99%

Leptin Levels in Gingival Crevicular Fluid During Orthodontic Tooth Movement

Dilsiz¹,

Kılıç²,

Aydın³

et al. 2010

The Angle Orthodontist

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“…Resimbozkurt et al, in 2006 evaluated the concentration of leptin in GCF of heavy smokers [28] . They showed that high concentration of leptin in GCF collected from the healthy gingival tissues of periodontal patients might serve a protective role.…”

Section: Discussionmentioning

confidence: 99%

Assessment of leptin concentration in peri-implant sulcular fluid during osseointegration of implants: Does it really vary?

Hassani¹,

Professor²,

Motamedi³

et al. 2017

Int J Dentistry Res

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Aim: Adequate bone healing is a prerequisite for implant success. Leptin plays an important role in regulating energy balance, increasing the activity of osteoblasts and decreasing the activity of osteoclasts. This study sought to assess the concentration of leptin in peri-implant sulcular fluid (PISF) during the process of osseointegration. Materials and Methods: This descriptive study was conducted on 20 patients qualified for implant placement. Samples were obtained from PISF at 10, 30 and 60 days following the placement of implants. A sample was also obtained from the gingival crevicular fluid (GCF) around a sound natural tooth in the opposite quadrant of the same jaw. The implant and the natural control tooth were isolated and samples of the PISF and GCF were obtained by inserting an absorbent paper strip into the sulcus for 30 seconds. Absorbent paper strips were then stored in microtubes at -20°C until the experiment. Samples were analyzed using leptin ELISA kit. Descriptive statistics were computed and the P value was set at .05. Results: The patients had a mean age of 45.1±12.6 years (range 21-68 years). The mean concentration of leptin in PISF was 1771.5±694.7 pg/mL at 10, 1675.9±423.9 pg/mL at 30 and 1651.5±608.6 pg/mL at 60 days. The mean concentration of leptin was 1754.9±625.2 pg/mL in GCF of the natural tooth on the day of surgery. Conclusions: Although leptin concentration varied and there is some difference in samples, it was not significantly different in PISF at 10, 30 and 60 days post-implantation.

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“…This was further supported by the study of Bozkurt 2006, who suggested that an elevated level of leptin in gingival crevicular fluid of healthy periodontium prolonging the life span of human primary osteoblasts by inhibiting apoptosis 8 .…”

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confidence: 84%