Giant neuroendocrine (Merkel cell) carcinoma of the skin

Tada, Joji; Toi, Yôichiro; Yamada, Taku; Yasutomi, Hiroshi; Nagao, Yo; Arakawa, Kiyoshi; Arata, Jirô

doi:10.1016/0190-9622(91)70125-l

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…Giant cases of MCC at the lower limbs, such as ours, are rarely reported and usually affect patients in the eighth decade or older. A review of the literature searching for patients with giant MCC revealed eleven reported cases (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Giant forms are still treated as typical cases of MCC.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy

Chatzinasiou

Papadavid

Korkolopoulou

et al. 2015

Dermatologic Therapy

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Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine carcinoma of the skin. MCC should be included in the diagnosis of a rapidly growing infiltrating mass and histology as well as laboratory investigations such as Merkel cell polyoma virus (MCPyV) detection are valuable in its diagnosis. We present an unusual case of giant MCC-positive MCPyV in a Greek woman located on the lower leg. Our patient is very unusual in terms of her extensive MCC and her rapid and complete response to radiotherapy.

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Section: Discussionmentioning

confidence: 99%

An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy

Chatzinasiou

Papadavid

Korkolopoulou

et al. 2015

Dermatologic Therapy

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“…Su aparición es de preferencia en la piel expuesta de varones de edad avanzada. Sólo un 10% de los casos se origina en zonas de piel no expuestas, siendo estos casos oncológica-mente más agresivos 4,5 . Clínicamente es indistingui-CARCINOMA DE CÉLULAS DE MERKEL EN LA REGIÓN PERIANAL.…”

Section: Discussionunclassified

Carcinoma de células de Merkel en la región perianal: Reporte de un caso

et al. 2009

Rev Chil Cir

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Merkel cell carcinoma. Report of one caseMerkel cell carcinoma is a rare neuroendocrine tumor typically found on sun-exposed areas such as face and extremities. We report a 57 years old male presenting with a tumor in the left perianal region that prior to surgery was catalogued as a perianal teratoma. The pathological study informed a Merkel cell tumor. It was locally excised and a cutaneous flap was made. Two years after surgery, the patient had pulmonary metastases and chemotherapy was started. Due to lack of response, it was discontinued after four cycles.Key words: Merkel cell tumor, local excision, pulmonary metastases. ResumenLos tumores de células de Merkel, son raros tumores neuroendocrinos que típicamente son encontrados en zonas expuestas al sol como cara y extremidades. Describimos un caso de un paciente de 57 años de edad con una tumoración en la región perianal que inicialmente se catalogó como un teratoma, cuya histopatología informó un tumor de células de Merkel. Se manejo con resección local amplia y colgajo cutáneo. Después de 2 años de la cirugía, el paciente evolucionó con claros signos de enfermedad metastásica pulmonar y actualmente se encuentra en manejo paliativo con quimioterapia.Palabras clave: Tumor de células de Merkel, resección local, enfermedad metastásica. IntroducciónEl carcinoma de células de Merkel o carcinoma neuroendocrino cutáneo es un tumor poco frecuente y agresivo, asociado a una elevada tendencia a invasión ganglionar, recurrencia y metástasis a distancia. La etiología de éste, así como en muchos de los tumores cutáneos descritos, es desconocida. La hipótesis más aceptada es aquella que describe el efecto oncogénico de las radiaciones solares aso- CASOS CLÍNICOS

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“…12 The behavior of Merkel cell tumors seems to be exceptionally aggressive when they appear in unusual locations such as the buttocks, scrotal sac, and vulva, with systemic metastases present either at presentation or soon thereafter. [1][2][3][4][5] The diagnosis of this tumor in our patient was based on histologic identification of the biopsy specimen and subsequent confirmation by immunohistochemistry and electron microscopy. Although Merkel cell carcinomas are a type of small-cell neuroendocrine carcinoma, they are primarily cutaneous and are distinguishable from neuroendocrine tumors found in the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

“…Merkel cell tumors are rare neuroendocrine small-cell tumors of skin that typically arise on sun-exposed areas and seem to have a more aggressive nature when found in atypical locations. [1][2][3][4][5] Biopsy is the only method of distinguishing and diagnosing these tumors. Although neuroendocrine tumors of the rectum have been described, we report what we believe is the first recorded case of a Merkel cell tumor arising in the anal canal.…”

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confidence: 99%

Merkel Cell (Neuroendocrine) Carcinoma of the Anal Canal

Paterson

Musselman²,

Chorneyko³

et al. 2003

Diseases of the Colon &Amp; Rectum

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Merkel cell tumors are rare neuroendocrine tumors typically found on sun-exposed areas such as extremities. We describe the case of a 42-year-old female with a Merkel cell tumor arising in the anal canal. The tumor was initially thought to represent a hemorrhoid arising during pregnancy and was excised locally after confirmation of extensive metastatic disease. The patient died 13 months after diagnosis with extensive metastatic disease involving the liver. In our search of the world literature there are several reports of neuroendocrine tumors in the rectum; however, no cases of documented Merkel cell tumors arising in the anal canal have been reported. These tumors seem to behave in a very aggressive manner when found in other atypical areas. The presentation symptoms were perianal discomfort and bleeding. Local excision may be the only surgical treatment necessary to control symptoms, given the propensity to early metastases and short life expectancy.

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Giant neuroendocrine (Merkel cell) carcinoma of the skin

Cited by 10 publications

References 22 publications

An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy

An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy

Carcinoma de células de Merkel en la región perianal: Reporte de un caso

Merkel Cell (Neuroendocrine) Carcinoma of the Anal Canal

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