Giant Magnetic Heat Induction of Magnesium‐Doped γ‐Fe₂O₃ Superparamagnetic Nanoparticles for Completely Killing Tumors

Abstract

Magnetic fluid hyperthermia has been recently considered as a Renaissance of cancer treatment modality due to its remarkably low side effects and high treatment efficacy compared to conventional chemotheraphy or radiotheraphy. However, insufficient AC induction heating power at a biological safe range of AC magnetic field (H ·f < 3.0-5.0 × 10 A m s ), and highly required biocompatibility of superparamagnetic nanoparticle (SPNP) hyperthermia agents are still remained as critical challenges for successful clinical hyperthermia applications. Here, newly developed highly biocompatible magnesium shallow doped γ-Fe O (Mg -γFe O ) SPNPs with exceptionally high intrinsic loss power (ILP) in a range of 14 nH m kg , which is an ≈100 times higher than that of commercial Fe O (Feridex, ILP = 0.15 nH m kg ) at H ·f = 1.23 × 10 A m s are reported. The significantly enhanced heat induction characteristics of Mg -γFe O are primarily due to the dramatically enhanced out-of-phase magnetic susceptibility and magnetically tailored AC/DC magnetic softness resulted from the systematically controlled Mg cations distribution and concentrations in octahedral site Fe vacancies of γ-Fe O instead of well-known Fe O SPNPs. In vitro and in vivo magnetic hyperthermia studies using Mg -γFe O nanofluids are conducted to estimate bioavailability and biofeasibility. Mg -γFe O nanofluids show promising hyperthermia effects to completely kill the tumors.

Antimicrobial spray nanocoating of supramolecular Fe(III)-tannic acid metal-organic coordination complex: applications to shoe insoles and fruits

“…The XPS spectra (Figure S2b ) confirmed the presence of Fe(III) in the film with peaks at 710 and 724 eV (Fe 2p 1/2 and 2p 3/2 ), and the disappearance of peaks around 91 eV (for gold) indicated that the SM( 5 )-[ 5 ] 5 film was stable against X-ray irradiation, and the film thickness was greater than the sampling depth of XPS (8~10 nm) 29 . In addition, the stoichiometry of Fe(III) and TA in the films was calculated to be about 4:1 based on narrow-scan XPS spectra, which was similar to the Fe(III)-TA-MOC films formed by multi-step LbL deposition 14 and biphasic interfacial assembly 23 .…”

“…The material-independent, universal Fe(III)-TA nanocoating has been demonstrated with a multitude of substrates, including planar and particulate ones 13 – 16 , viruses 18 and living cells 19 – 21 , and dentinal tubules 22 . The Fe(III)-TA-MOC also has recently been utilized for biphasic interfacial film formation, such as hollow microcapsules in the water-oil biphasic system 23 .…”

Non‐Magnetic Injectable Implant for Magnetic Field‐Driven Thermochemotherapy and Dual Stimuli‐Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics

“…Recently, special attention has been paid to the development of high‐performance thermal agents. However, it seems such research was only restricted to the MNPs . Though termed as “magnetic‐mediated hyperthermia,” it should be clarified that “magnetic” does not necessarily limit the choice of the thermal agents only within magnetic materials.…”

Magnetic iron oxide nanomaterials: A key player in cancer nanomedicine

“…One of the aims in developing magnetothermal therapies is to enhance the heating efficiency of MIONs in order to reach desirable temperature with minimum dosage and power density. Recent progress in optimizing MIONs, such as synthesizing anisotropic MIONs, 31 nanoassembly, 70 core‐shell nanostructures, 71 and ion‐doped MIONs, 72 has achieved unprecedented magnetic heating efficiency (>1 kW/g). However, the dynamical magnetic response of MIONs is confined by the complex biological environments.…”