Magnetic iron oxide nanomaterials: A key player in cancer nanomedicine

Liang, Chunyong; Zhang, Xinglin; Cheng, Zijin; Yang, Moon-Sik; Huang, Wei; Dong, Xiaochen

doi:10.1002/viw.20200046

Cited by 32 publications

(19 citation statements)

References 82 publications

(98 reference statements)

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“…However, to date, only iron oxide nanoparticles have been approved for the magnetic response diagnosis and the magnetic hyperthermia tumor therapy (Park et al, 2017 ; Shi et al, 2017 ). Few clinical trials have been reported for any tumor therapy based on ferrite nanoparticle-induced ROS (Liang et al, 2020 ). The ferrite nanoparticle-induced ROS can kill the cancer cell and also can trigger the toxic effect on the normal tissues and vasculature.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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Ferrite nanoparticles have been widely used in the biomedical field (such as magnetic targeting, magnetic resonance imaging, magnetic hyperthermia, etc.) due to their appealing magnetic properties. In tumor acidic microenvironment, ferrite nanoparticles show intrinsic peroxidase-like activities, which can catalyze the Fenton reaction of hydrogen peroxide (H2O2) to produce highly toxic hydroxyl free radicals (•OH), causing the death of tumor cell. Recent progresses in this field have shown that the enzymatic activity of ferrite can be improved via converting external field energy such as alternating magnetic field and near-infrared laser into nanoscale heat to produce more •OH, enhancing the killing effect on tumor cells. On the other hand, combined with other nanomaterials or drugs for cascade reactions, the production of reactive oxygen species (ROS) can also be increased to obtain more efficient cancer therapy. In this review, we will discuss the current status and progress of the application of ferrite nanoparticles in ROS-mediated cancer therapy and try to provide new ideas for this area.

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Section: Conclusion and Future Outlookmentioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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“…[ 148 ] Fe 3 O 4 was found with property of peroxidase‐mimicking in 2007, [ 149 ] leading to its broad range of biomedical applications. [ 150–152 ] The successful development of Fe 3 O 4 also triggers the developing transition metal‐based nanozymes and noble metal based nanozymes as well as their biomedical applications, such as Co, [ 153 ] Zr, [ 154 ] V, [ 155 ] Pt, [ 156 ] and Au. [ 157 ] Notably, the well‐designed carbon nanomaterials are considered as ideal candidates for nanozyme and have exhibited with enhanced biocatalytic performance as peroxidase mimics, superoxide dismutase (SOD) mimics and hydrolase mimics.…”

Section: The Application Of Sustainable Carbon Materials In Catalysismentioning

confidence: 99%

Sustainable Carbon Materials toward Emerging Applications

Lan

Yang

et al. 2021

Small Methods

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It is desirable for a sustainable society that the production and utilization of renewable materials are net‐zero in terms of carbon emissions. Carbon materials with emerging applications in CO2 utilization, renewable energy storage and conversion, and biomedicine have attracted much attention both academically and industrially. However, the preparation process of some new carbon materials suffers from energy consumption and environmental pollution issues. Therefore, the development of low‐cost, scalable, industrially and economically attractive, sustainable carbon material preparation methods are required. In this regard, the use of biomass and its derivatives as a precursor of carbon materials is a major feature of sustainability. Recent advances in the synthetic strategy of sustainable carbon materials and their emerging applications are summarized in this short review. Emphasis is made on the discussion of the original intentions and various sustainable strategies for producing sustainable carbon materials. This review provides basic insights and significant guidelines for the further design of sustainable carbon materials and their emerging applications in catalysis and the biomedical field.

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“…Nanomedicine can be characterized into three broad categories: regenerative medicine, nano-diagnosis and nano-therapy (Figure 5). Regenerative medicine utilizes nanomaterials such as carbon nanostructures, diamond polymers, polymeric nanoparticles and silica nanoparticles to replace or repair damaged tissues or organs through surface modeling [84,87]. In nano-diagnostics, nanoparticles are used both in vitro and in vivo as imaging sensors to detect abnormal cells or diseases that can be detected outside of the host in biological fluids [85].…”

Section: The Age Of Nanomedicinementioning

confidence: 99%

Nanomedicine-Mediated Optimization of Immunotherapeutic Approaches in Cervical Cancer

Venkatas

Singh

2021

Nanomedicine (Lond.)

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Cervical cancer shows immense complexity at the epigenetic, genetic and cellular levels, limiting conventional treatment. Immunotherapy has revolutionized nanomedicine and rejuvenated the field of tumor immunology. Although several immunotherapeutic approaches have shown favorable clinical responses, their efficacies vary, with subsets of patients benefitting. The success of cancer immunotherapy requires the enhancement of cytokines and antitumor effector cell production and activation. Recently, the feasibility of nanoparticle-based cytokine approaches in tumor immunotherapy has been highlighted. Immunotherapeutic nanoparticle-based platforms form a novel strategy enabling researchers to co-deliver immunomodulatory agents, target tumors, improve pharmacokinetics and minimize collateral toxicity to healthy cells. This review looks at the potential of immunotherapy and nanotechnologically enhanced immunotherapeutic approaches for cervical cancer.

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Magnetic iron oxide nanomaterials: A key player in cancer nanomedicine

Cited by 32 publications

References 82 publications

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Sustainable Carbon Materials toward Emerging Applications

Nanomedicine-Mediated Optimization of Immunotherapeutic Approaches in Cervical Cancer

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