2021
DOI: 10.2217/nnm-2021-0044
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Nanomedicine-Mediated Optimization of Immunotherapeutic Approaches in Cervical Cancer

Abstract: Cervical cancer shows immense complexity at the epigenetic, genetic and cellular levels, limiting conventional treatment. Immunotherapy has revolutionized nanomedicine and rejuvenated the field of tumor immunology. Although several immunotherapeutic approaches have shown favorable clinical responses, their efficacies vary, with subsets of patients benefitting. The success of cancer immunotherapy requires the enhancement of cytokines and antitumor effector cell production and activation. Recently, the feasibili… Show more

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Cited by 13 publications
(9 citation statements)
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References 125 publications
(163 reference statements)
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“…This malleability of nanoparticles (NPs) allows for the attachment of various biomolecules, thereby allowing for the efficient and safe transportation of pharmacologically active agents, such as genes or drugs. NP delivery vehicles of 1-100 nm in size have the ability to penetrate significant physiological barriers such as those found in the lungs, liver, gastrointestinal fluid, blood, tumour vasculature, mucosal membranes, and the blood-brain barrier [57][58][59]. Various NPs have been utilized in this regard, each portraying their unique characteristics as a therapeutic, diagnostic or theranostic tool.…”
Section: Nanoparticles and Nanomedicinementioning
confidence: 99%
“…This malleability of nanoparticles (NPs) allows for the attachment of various biomolecules, thereby allowing for the efficient and safe transportation of pharmacologically active agents, such as genes or drugs. NP delivery vehicles of 1-100 nm in size have the ability to penetrate significant physiological barriers such as those found in the lungs, liver, gastrointestinal fluid, blood, tumour vasculature, mucosal membranes, and the blood-brain barrier [57][58][59]. Various NPs have been utilized in this regard, each portraying their unique characteristics as a therapeutic, diagnostic or theranostic tool.…”
Section: Nanoparticles and Nanomedicinementioning
confidence: 99%
“…One of the most popular uses of NPs is as de-livery vehicles for therapeutic agents to tumour sites. NPs less than 100 nm in size have the ability to penetrate physiological barriers, including those found in the lung, blood, nervous system, and tumour vasculature [39] . Thus, the development of nanodelivery systems can potentially improve cancer therapy and overcome challenges faced by conventional treatments such as chemotherapy and radiation therapy.…”
Section: Nanomedicinementioning
confidence: 99%
“…The principal use of NPs is to overcome challenges faced by commonly used drugs, such as poor stability, potential immunogenicity, solubility, and reduced plasma half-life [ 37 ]. Nanodelivery systems can increase the therapeutics circulation time, allow several different administration routes, circumvent potential solubility issues using hydrophobic molecules, and cater for favorable biodistribution of the therapeutic gene or drug [ 38 ]. Overall, their ideal size, quantum properties, ability to be conjugated to pharmacologically active agents, and favorable surface-to-mass ratio assures their potential as therapeutic delivery systems [ 39 ].…”
Section: Nanomedicinementioning
confidence: 99%
“…Overall, their ideal size, quantum properties, ability to be conjugated to pharmacologically active agents, and favorable surface-to-mass ratio assures their potential as therapeutic delivery systems [ 39 ]. Nanoscale particles (<100 nm) favor the passage through biological barriers, such as those found in the nervous system, lung, and vasculature surrounding tumors [ 38 , 40 ]. Nanomaterials have shown the ability to facilitate the stability and protection of genetic materials such as DNA, mRNA, and siRNA and to enhance transfection efficacy with low cytotoxicity [ 41 , 42 , 43 ].…”
Section: Nanomedicinementioning
confidence: 99%