Non‐Magnetic Injectable Implant for Magnetic Field‐Driven Thermochemotherapy and Dual Stimuli‐Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics

Abstract

Scheme 1. Schematic illustration of combined therapy in breast cancer with liquid metal (LM) and drug loaded mesoporous silica hybrid (DOX-MS/LM) 1900511 (10 of 11) www.advancedsciencenews.com Small 2019, 15, 1900511cytotoxic and anti-tumor effect, both in vitro and in vivo. The high density of LM enabled it to be scanned for CT scan, and the CT-enhanced effect can last for a longer time, up to 5 days. The systematic biological evaluation of LM according to ISO10993 and GB/T16886 proved the ideal biocompatibility of LM as an implantable device. This study explored a new transformable LMbased biomedical platform as an effective candidate for low-toxic and multifunctional cancer theranostic applications.

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

“…Cumulative release of DPLGA@[RAW-4T1] NPs at 72 h approached 70% and 79% at pH 5.5 and 4.7, respectively, which was much higher than that at pH 7.4 (approximately 40%). This unexpected result may be due to the increased solubility of Dox under low pH, which can cause Dox to diffuse from the membrane-coated NPs to the surrounding medium [63,64].…”

Galvanic replacement reaction for in situ fabrication of litchi-shaped heterogeneous liquid metal-Au nano-composite for radio-photothermal cancer therapy

“…Rapid progress on the biomedical application of liquid metals (LM) has witnessed the tremendous research advance of these novel functional materials [ [1] , [2] , [3] , [4] , [5] ]. Simultaneously owning multi-properties such as high fluidity, excellent thermal and electrical conductivities, ideal biocompatibility, good radiopacity, controllable behaviors and conformability associated with reversible liquid-solid phase transition, facile manufacture and along with affordable cost, LM biomaterials have been widely applied in biological imaging [ 6 , 7 ], bone repair [ 8 ], drug delivery [ [9] , [10] , [11] ], magnetic hyperthermia [ 12 , 13 ], photothermal therapy [ [14] , [15] , [16] ], tumor embolotherapy [ 17 ], microwave dynamic therapy and microwave thermal therapy [ 18 ]. Such ‘One material, Multi-functionalities’ is rather unusual among many existing top materials and therefore it is noteworthy to recognize that a new direction of biomedical category: the LM biomaterials have formed [ 2 ].…”

“…Therefore, it would be wise to combine these two components into one nano-hybrid platform by virtue of the interfacial galvanic replacement reactions offered by LM. In our previous demonstration, the EGaIn alloy displays magnetic field-driven thermochemotherapy and dual stimuli-responsive drug for cancer theranostics [ 13 ]. Here, we discovered that the EGaIn-Au nano-composite could effectively response to X-ray and NIR laser irradiation, which endowed the nano-composite with photothermal conversion ability and radiosensitization effect to kill cancer cells and achieve excellent therapeutic effect.…”

Stimulus-Responsive Nanomedicines for Disease Diagnosis and Treatment

“…When SPN released singlet oxygen, it could not only carry out photodynamic therapy, but also released proenzyme to degrade cancer-specific RNA, the synergistic treatment by chemo/phototherapy for cancers [ 223 ] ( Figure 11 ). Other dual/multiple stimuli-responsive systems for cancer treatments include pH/magnetic responsive systems [ 224 , 225 ] and other pH-based multiple stimuli-responsive systems [ 226 , 227 , 228 ].…”