Giant eccrine adenocarcinoma with skin and lymph node metastases: favourable response to chemotherapy

Abstract

4 Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997; 34: 391-399. 5 Javor J, Bucova M, Ferencik S, Grosse-Wilde H, Buc M. Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population. Int J Immunogenet 2007; 34: 273-280. 6 Paraskevaidis A, Drakoulis N, Roots I et al. Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne. Dermatology 1998; 196: 171-175. 7 Sobjanek M, Zablotna M, Sokolowska-Wojdylo M. Polymorphism in cytochrome P-450 (CYP1A1) in acne vulgaris: preliminary study. Post Dermatol Alergol 2007; 24: 69-72. 8 He L, Yang Z, Yu H et al. The relationship between CYP17 -34T/C polymorphism and acne in Chinese subjects revealed by sequencing. EditorA 45-year-old man presented with a complaint of a 4-month history of two progressively enlarging skin tumours, one each on the occipital scalp and nape (Fig. 1a,b). Initially, the scalp lesion began first, and the nape lesion developed a few days later. Multiple enlarged lymph nodes could be palpated in the neck and supraclavicular area. Incisional biopsies of both lesions were

Head and neck sweat gland adenocarcinoma: A population‐based perspective of a rare entity

“…Two particular studies report reduced recurrence rates when using this treatment modality . Although there is no general consensus on the use of radiotherapy, sweat gland carcinomas tend to be resistant to irradiation; therefore, radiation is generally not recommended as primary therapy . Because chemotherapy use is infrequent, its role in treatment has yet to be fully elucidated.…”

Primary Eccrine Adenocarcinoma of the Skin: A Single-centre Experience of 10 Years

“…Gross features of the tumour are undefined, and variants have been reported; therefore, histological evaluation is necessary for diagnosis (1,2). Exclusion of a visceral adenocarcinoma with cutaneous metastasis is another important criterion for confirming a diagnosis of primary eccrine adenocarcinoma (2,3).…”

“…Traditionally, the recommended treatment for primary eccrine adenocarcinoma of the skin has been wide local excision with possible regional lymph node dissection (4); however, given the lack of published reports, there is no standard of care for management. Recently, Mohs micrographic surgery (MMS) has become an attractive treatment option for this type of tumour (3,5,6). For the past decade, we have treated primary eccrine adenocarcinomas of the skin based on a clinical assessment involving a total body computed tomographic and positron emission scan (positron emission tomography/computed tomography; PET/CT scan) for metastatic work-up and MMS for complete removal of the tumour.…”