Primary Eccrine Adenocarcinoma of the Skin: A Single-centre Experience of 10 Years

Head and neck sweat gland adenocarcinoma: A population‐based perspective of a rare entity

“…Several studies report that SGA of eccrine origin may in fact display a propensity for the head and neck. [8][9][10][11] Our analysis suggests that HNSGA typically is identified early in its progression and mostly appears to be locally aggressive in behavior. Despite the limited AJCC-staging data available, only 16.6% of cases displayed AJCC stage III or IV.…”

“…Our data suggest that HNSGA originating from eccrine glands is more common over apocrine glands. Several studies report that SGA of eccrine origin may in fact display a propensity for the head and neck …”

“…Complete extirpation of local disease is particularly important because recurrence of up to 30% has been reported . Many studies report the increased utilization of Mohs micrographic surgery, particularly for smaller malignancies or those that are well or moderately differentiated . Two particular studies report reduced recurrence rates when using this treatment modality .…”

“…Although there is no established algorithm for the treatment of SGA, there is general consensus in the literature that primary surgical excision with wide margins (1 cm-2 cm) and therapeutic neck dissection in the presence of clinically positive nodes is the recommended treatment for all sweat gland carcinomas, including SGA. 2,6,7,9,10,[14][15][16] Complete extirpation of local disease is particularly important because recurrence of up to 30% has been reported. 6,12 Many studies report the increased utilization of Mohs micrographic surgery, particularly for smaller malignancies or those that are well or moderately differentiated.…”

“…6,12 Many studies report the increased utilization of Mohs micrographic surgery, particularly for smaller malignancies or those that are well or moderately differentiated. 6,10,12 Two particular studies report reduced recurrence rates when using this treatment modality. 17,18 Although there is no general consensus on the use of radiotherapy, sweat gland carcinomas tend to be resistant to irradiation; therefore, radiation is generally not recommended as primary therapy.…”