Giant condyloma acuminatum of Buschke and Löwenstein: successful surgical treatment

Talwar, Ashutosh; Puri, Neerja; Singh, Majhail

doi:10.1258/ijsa.2009.009159

Cited by 12 publications

(14 citation statements)

References 13 publications

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“…Clinically, this variant is a slow-growing cauliflower-like growth that is locally invasive. 13 Although it is usually benign, up to one-third of the cases progress to malignancy. 13 , 14 Because of the risk of malignancy, surgery is the first-line treatment for giant condyloma acuminate.…”

Section: Discussionmentioning

confidence: 99%

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report

Hum

Chow

Schuurmans

et al. 2018

SAGE Open Medical Case Reports

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Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. The patient, a 66-year-old female, was referred to Dermatology for large protruding verrucous plaques that covered the entire surface of her external vulva, perineum and perianal area. These lesions developed after being treated for genital warts with cantharidin. Four other cases treated with imiquimod were identified in the literature but either required surgery, higher doses or longer duration of treatment or involved pediatric populations. In patients who are not amenable to surgery, topical imiquimod may be a novel standalone or an adjunctive therapy for giant condyloma acuminata.

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Section: Discussionmentioning

confidence: 99%

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report

Hum

Chow

Schuurmans

et al. 2018

SAGE Open Medical Case Reports

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“…In our case report, the giant condyloma was due to immunodeficiency (post-allogeneic transplantation). Immunosuppressed solid organ allograft recipients rarely develop anogenital lesions (2.3%), and giant condyloma after bone marrow transplantation is extremely rare (0.3 to 1.3%) [ 2 , 3 , 10 ]. Immunodeficiency is common after allogeneic stem cell transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, human leukocyte antigen (HLA)-mismatching between the donor and the recipient and T-cell depletion can delay immune recovery. Ongoing immunosuppression in patients undergoing transplantation provides fertile ground for untamed proliferation of the HPV virus, which leads to a higher chance of dissemination, local invasion, and oncogenesis [ 2 , 3 , 11 , 12 ]. To date, no definitive therapeutic strategies have been established [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for giant condyloma acuminatum (GCA) include an immunodeficient state, such as human immunodeficiency virus (HIV) infection, post-organ transplantation, and post-allogeneic bone marrow transplantation. However, reports of giant condyloma after bone marrow transplantation are extremely rare (0.3 to 1.3%) [ 1 – 3 ]. There are various treatment methods including wide surgical resection, however, no definitive therapeutic guideline has yet been established [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report

et al. 2015

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IntroductionCondyloma acuminatum are caused by human papillomavirus. Giant condyloma acuminatum is a locally invasive, destructive, and large sized mass. Risk factors for the development of giant condyloma acuminatum include an immunodeficient state, such as human immunodeficiency virus infection, post-organ transplantation, or post-allogeneic bone marrow transplantation. However, reports of giant condyloma after bone marrow transplantation are extremely rare (0.3 to 1.3%). The standard treatment for giant condyloma acuminatum is recommended as wide surgical resection due to its high rate of success and low rate of recurrence.Case presentationA 31-year-old Korean man presented to our hospital with anal discomfort for more than one month due to a protruding mass. He had a history of BCR-ABL-positive acute lymphoblastic leukemia and had undergone an allogenic stem cell transplantation. Gross findings revealed a large perianal cauliflower-like mass over 7cm in size with invasion of the anal orifice. He was diagnosed with giant anal condyloma occurring after an allogeneic bone marrow transplantation. However, we achieved successful treatment using a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.ConclusionsWe report an extremely rare case of giant condyloma acuminatum of anus due to human papillomavirus type six in a patient with acute lymphoblastic leukemia following an allogeneic bone marrow transplantation. The tumor was successfully treated with a combination of topical podophyllin and cryotherapy and transanal surgical excision, followed by bleomycin irrigation.

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“…BLT is a slow growing cauliflower-like tumour, but unlike simple condyloma, it is locally aggressive and destructive 4 . It was originally described in 1896 by Buschke and Loewenstein in 1925 and later on was named by Loewenstein “carcinoma-like condylomata acuminata” of the penis 6 .…”

Section: Introductionmentioning

confidence: 99%

Buschke–Lowenstein tumour of glans penis

Agarwal

Nirwal

Singh

2014

International Journal of Surgery Case Reports

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INTRODUCTIONBuschke–Löwenstein tumour, also known as Giant condyloma acuminatum, is a rare, sexually transmitted disease that affects ano-genital region. BLT is a slow growing cauliflower-like tumour, locally aggressive and destructive. Human papillomavirus has been identified as an important contributory factor in the development of tumour.PRESENTATION OF CASEA 45 year uncircumcised male presented with complaints of cauliflower like growth on glans penis. Growth started as a small papule on the corona sulcus at 12 O’clock position 6 months back. Patient developed pain and dysuria due to compression of urethral meatus. Patient has history of multiple sexual partners.DISCUSSIONBLT, first described by Buschke and Lowenstein in 1925. They observed a penile lesion that clinically resembled both common condyloma acuminata and squamous cell carcinoma, but differing from both of them regarding the biological behaviour and the histopathological appearance. GCA can be differentiated from ordinary condylomas by the characteristic “pushing” rather than “infiltrating” effect that tends to compress and displace the underlying tissue.CONCLUSIONWe have successfully treated a penile BLT with surgical excision and no relapse up to 6 months. Surgical excision could be considered an effective therapy in the treatment.

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Giant condyloma acuminatum of Buschke and Löwenstein: successful surgical treatment

Cited by 12 publications

References 13 publications

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report

Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report

Giant anal condyloma (giant condyloma acuminatum of anus) after allogeneic bone marrow transplantation associated with human papillomavirus: a case report

Buschke–Lowenstein tumour of glans penis

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