Case of giant vulvar condyloma acuminata successfully treated with imiquimod 3.75% cream: A case report

Abstract

Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. The patient, a 66-year-old female, was referred to Dermatology for large protruding verrucous plaques that covered the entire surface of her external vulva, perineum and perianal area. These lesions developed after being treated for genital warts with cantharidin. Four other cases treated with imiquimod were identified in the literature but either required surgery, higher doses or longer duration of treatment or involved pediatric populations. In patients who are not amenable to surgery, topical imiquimod may be a novel standalone or an adjunctive therapy for giant condyloma acuminata.

Radical Excision of a Buschke-Lowenstein Tumor and Excellent Reconstruction of the Tissue with Cutaneous Flap and Split-thickness Skin Graft

“…[23][24][25] The surgical treatment represents the "gold standard" therapy and consists of full-thickness excision and tumor-free margins control. [3,8,9,26,27] Our case of great size BLT involving widely prepubic, penopubic, and penile shaft skin with no malignant transformation was treated by wide tissue excision. Very large excision defects were successfully covered by fatty subcutaneous tissue flaps and split-thickness skin graft.…”

Massive Condyloma Acuminata on a 20-week Pregnant Primigravida

“…Imiquimod is used for extensive condyloma, which has difficulty with cryotherapy and laser therapy [22]. Topical imiquimod 3.75% cream provides optimal results in the treatment of giant condyloma in a person aged 66 years, who is at risk of other procedures [23]. The use of imiquimod 5% cream also succeeded in curing condyloma in a 2-year-old baby, with a dose of 3 times per week, for 12 weeks [24].…”

Peri-anal and genital localization of giant condyloma acuminatum or Buschke–Lowenstein’s Tumor: A report of two cases

“…Rare cases of total regression of BLT have been reported by Hum et al . [ 13 ] and Dinleyici et al . [ 14 ] after application of imiquimod 3.75% three times per week.…”