Buschke–Lowenstein tumour of glans penis

Abstract

INTRODUCTIONBuschke–Löwenstein tumour, also known as Giant condyloma acuminatum, is a rare, sexually transmitted disease that affects ano-genital region. BLT is a slow growing cauliflower-like tumour, locally aggressive and destructive. Human papillomavirus has been identified as an important contributory factor in the development of tumour.PRESENTATION OF CASEA 45 year uncircumcised male presented with complaints of cauliflower like growth on glans penis. Growth started as a small papule on the corona sulcus at 12 O’clock position 6 months back. Patient developed pain and dysuria due to compression of urethral meatus. Patient has history of multiple sexual partners.DISCUSSIONBLT, first described by Buschke and Lowenstein in 1925. They observed a penile lesion that clinically resembled both common condyloma acuminata and squamous cell carcinoma, but differing from both of them regarding the biological behaviour and the histopathological appearance. GCA can be differentiated from ordinary condylomas by the characteristic “pushing” rather than “infiltrating” effect that tends to compress and displace the underlying tissue.CONCLUSIONWe have successfully treated a penile BLT with surgical excision and no relapse up to 6 months. Surgical excision could be considered an effective therapy in the treatment.

Electrocautery Resection, Shaving with a Scalpel, and Podophyllin: a Combination Therapy for Giant Condyloma Acuminatum

“…In our case, in order to prevent any injuries to the penis and its functions, we used electrocautery resection for tumor debulking, followed by shaving the lesion from above the skin in order to preserve the skin and the underlying sensory nerve endings. Consequently, regrowth of the lesion three weeks after the operation was expected [ 7 ]. Thus, further local treatment involving with podophyllin home therapy and office-based cryotherapy with liquid nitrogen was inevitable, and such therapeutic strategies have been recommended in the literature [ 1 ].…”

Buschke–Löwenstein tumor of the penis

“…Treatment with interferons 2α and 2β combined with laser therapy (Nd:YAG) has been described, as well as cryosurgery with some cases of success. Radical surgical excision with wide surgical margins remains the first line of treatment, with a higher success rate (63-91%) and a lower rate of relapse [8]. Nevertheless, penile skin loss and repair of the urethra can be a challenge for urologists.…”

Buschke-Löwenstein Tumour: Successful Treatment with Minimally Invasive Techniques

“…The human papillomavirus (HPV) has been identified as an important contributory factor in the development of BLT [ 4 ].…”

“…Although this is a well-differentiated, benign lesion, its management is often challenging due to the size, probable local invasion, and elevated recurrence rates [ 4 ].…”