Buschke-Löwenstein Tumour: Successful Treatment with Minimally Invasive Techniques

Abstract

We report a case of an 80-year-old female who presented with a four-year history of a growing mass in the perianal area with pain and bleeding during defaecation. Clinical examination revealed a locally destructive, cauliflower-like, verrucous mass measuring 10 × 12 cm in diameter. Histologic findings revealed a moderate degree of dysplasia of the epithelium with koilocytosis atypia, acanthosis, and parakeratosis, features that are consistent with Buschke-Löwenstein tumour. Polymerase-chain-reaction assay for human papillomavirus (HPV) showed an infection with HPV type 11. Full-thickness excision of involved skin was undertaken by cryotherapy and electrocautery over five months. The entire wound was left open to heal by secondary intention. After 3 years of follow-up, the patient has not experienced a recurrence, with excellent functional results, but the cosmetic results were satisfactory. These minimally invasive techniques can be safer and more cost-effective than surgery and the General Practitioner can play a key role in diagnosis.

Giant anogenital tumor of Buschke–Löwenstein in a patient living with human immunodeficiency virus/acquired immunodeficiency syndrome: a case report

“…However, coinfected HPV–HIV patients have a greater risk of failure or recurrence [ 18 ]. Fear of stigma and a feeling of shame seemed to be among the most important factors enhancing the evolution of this tumor [ 24 , 25 ].…”

Vulvar condyloma of Buschke and Löwenstein: an unusual tumour in developed countries

“…Buschke-Löwenstein condylomas are extremely rare benign tumours and reported cases in developed countries are even scarcer 1 2. Most commonly, they affect the penis and perianal regions, but also the vulva and the vagina 1.…”

“…Due to its rarity, consensus on management and treatment is challenging and many treatment options are mentioned in literature, such as podophyllin, 5-fluorouracil, methotrexate, bleomycin, interferon, oral retinoid therapy and even paiteling 2 9 12–14. Minimally-invasive techniques (cryotherapy, photodynamic therapy, CO2 laser ablation, electrosurgery or curettage) and radiotherapy may also be used in some smaller lesions 2 9 14. Wide surgical excision with tumour-free margins seems to be the most accepted approach for large lesions 15.…”

Buschke‐Lowenstein tumor: Use of dermal matrix for reconstruction of genital area

“…4 High recurrence rates after resection and elevated incidence of malignant transformation into an invasive squamous cell carcinoma are features of BLT. 5 Wide surgery is considered the mainstay of treatment. [1][2][3][4][5][6] A 64-year-old Moroccan man was referred to our dermatology department with a 10-year-history of a growing mass in the genital region.…”

“…5 Wide surgery is considered the mainstay of treatment. [1][2][3][4][5][6] A 64-year-old Moroccan man was referred to our dermatology department with a 10-year-history of a growing mass in the genital region. He denied a history of immunodeficiency syndromes.…”