Ghrelin, leptin and insulin in healthy children: Relationship with anthropometry, gender, and age distribution

Wilasco, Maria Inês A.; Goldani, Helena Ayako Sueno; Dornelles, Cristina; Maurer, Rafael Lucyk; Kieling, Carlos Oscar; Porowski, Marilene; Silveira, Themis Reverbel da

doi:10.1016/j.regpep.2011.08.013

Cited by 33 publications

(30 citation statements)

References 26 publications

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“…In our sample, adiponectin and leptin levels were slightly higher in girls than in boys, which is in accordance with the findings in children 3,19 and in adults, 4 reporting higher leptin levels in females than in males.…”

Section: Leptin and Adiponectin Values For Children E Erhardt Et Alsupporting

confidence: 92%

“…There is only one Mexican cross-sectional study 19 that investigated 190 school-age children classified as obese and 196 children classified as eutrophic. A significant difference (P o 0.001) was found between eutrophic and obese children with respect to anthropometric and metabolic measurements.…”

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 99%

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Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

et al. 2014

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on behalf of the IDEFICS consortium OBJECTIVE: To establish age-and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children. SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n = 539) in our analysis. Using the General Additive Model for Location Scale and Shape, age-and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n = 1015) and the whole study sample (n = 1338). RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from − 2.2 to 4.6 μg ml − 1 and from 2.2 to 4.8 ng ml − 1 for adiponectin and leptin, respectively. CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

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Section: Leptin and Adiponectin Values For Children E Erhardt Et Alsupporting

confidence: 92%

Section: Leptin and Adiponectin Values For Children E Erhardt Et Almentioning

confidence: 99%

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

et al. 2014

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“…Karakosta et al calculated gender-specific reference intervals for leptin levels in cord blood in 398 healthy neonates in Crete and found that females had higher levels of this hormone than males [25]. Leptin levels have been shown to be consistently higher in females than in males later in life [26], [27]. We hypothesize that these differences are related to differences in body composition or hormone levels in males and females.…”

Section: Discussionmentioning

confidence: 78%

Serum Reference Values for Leptin in Healthy Infants

et al. 2014

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ObjectiveReports on leptin concentrations in pediatric populations lack reference values for infants in the first months of life. Our study was conducted on healthy full-term infants between 2002 and 2012 to determine serum leptin reference values in subjects less than 18 months old.MethodsRoutine outpatient blood tests for serum leptin were performed on 317 infants using a radioimmunoassay method. The median and 10th–90th percentiles were calculated to obtain reference values using quantile regression. Values established in this study were compared with another independent cohort of 110 infants.ResultsThe median (IQR) serum leptin concentration in the infants was 2.37 (3.26) ng/ml (n = 317). The median leptin concentration was 2.81 (3.49) ng/ml (n = 202) in infants younger than 6 months of age, 1.44 (2.27) ng/ml (n = 59) in infants between 6–12 months of age and 1.77 (2.05) ng/ml (n = 56) in infants between 12–18 months of age. We obtained leptin reference values based on age by estimating the lower and upper percentiles. In the entire cohort, the median (IQR) leptin concentration was 2.22 (3.11) ng/ml in males (n = 168) and 2.60 (3.32) ng/ml in females (n = 149). According to the type of feeding median serum leptin concentration was higher in breast-fed infants (n = 188) than in formula-fed infants (n = 129) (2.63 (3.34) ng/ml vs. 2.12 (2.77) ng/ml; p<0.05).ConclusionsOur data revealed no gender difference in leptin concentration in early infancy. After 6 months of life, leptin concentrations decreased slightly. We used a large cohort to confirm that breast-fed infants had significantly higher serum leptin levels than formula-fed infants during the first 6 months of life, although this difference disappeared later in life. In this study, we defined the leptin reference range in healthy infants in the first 18 months of life according to the Clinical and Laboratory Standards Institute (CLSI).

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“…The relationship between ghrelin plasma levels and the age of the children seemed to be controversial, and data were inconsistent (6,8,28,29) . This study revealed that the inverse correlation of ghrelin and age is present only in healthy children but not in the PID or the RRTI groups.…”

Section: Discussionmentioning

confidence: 99%

Relation among ghrelin, nutritional status, and immunity in children

Gorczyca

Basiewicz-Worsztynowicz

Augustyniak

et al. 2012

Journal of Pediatric Endocrinology and Metabolism

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Ghrelin, leptin and insulin in healthy children: Relationship with anthropometry, gender, and age distribution

Abstract: Ghrelin showed an inverse correlation with age and leptin showed a direct correlation with anthropometric parameters and female gender in healthy children. Insulin did not show any correlation.

Cited by 33 publications

References 26 publications

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort

Serum Reference Values for Leptin in Healthy Infants

Relation among ghrelin, nutritional status, and immunity in children

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