Getting nervous about regeneration

The Potential of Nail Mini-Organ Stem Cells in Skin, Nail and Digit Tips Regeneration

“…Subsequently, the Runx2 + progenitors and Sp7 + osteoblasts proliferation is inhibited, and so the production of Bmp4 [ 15 ]. Similar suppression of blastema development was observed in control mice that were subjected to the surgical removal of the nerves [ 77 , 78 ]. The unnerved blastema is deprived of nerve-associated Sox2 -positive dedifferentiated Schwann cell precursors (SCPs) and their secretions: platelet-derived growth factor AA (PDGF-AA) and Oncostatin M (OSM) ( Figure 4 ) [ 53 ].…”

“…The unnerved blastema is deprived of nerve-associated Sox2 -positive dedifferentiated Schwann cell precursors (SCPs) and their secretions: platelet-derived growth factor AA (PDGF-AA) and Oncostatin M (OSM) ( Figure 4 ) [ 53 ]. The absence of SCPs manifestly hinders the proliferation of blastema mesenchymal cells and bone regeneration [ 53 , 77 ]. Moreover, loss of nerves, which should provide a migration route for the mesenchymal precursors, prevents their deposition in the regeneration of mesenchymal tissues, bone and dermis [ 54 ].…”

Schwann cells: an emerging player in tissue regeneration

“…Specifically, our work highlights the necessity of trophic support by SCPs to sufficiently expand the mesenchymal blastemal during reconstitution of the digit following amputation of the distal phalanx (3). However, these findings also underscore the need for further clarity of the many uncertainties discussed in the aforementioned commentaries (4,5).…”