Schwann cells: an emerging player in tissue regeneration

Johnston, Adam

doi:10.21037/sci.2017.02.05

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…At the same time, Schwann cells produce factors that counterbalance proinflammatory cytokines, including IL-10 and erythropoietin (77)(78)(79). A similar phenotypic switch by Schwann cells occurs during injury and repair of nonneuronal tissues (87,88).…”

Section: Neuroimmune Axis In Cancermentioning

confidence: 89%

The Neuroimmune Axis in the Tumor Microenvironment

Shurin

Zlotnikov

et al. 2020

The Journal of Immunology

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Cancer is a complex ecosystem and should be considered in the context of its cellular and molecular microenvironment, which includes the nerves. Peripheral nerves can modulate phenotype and behavior of the malignant cells and thus affect tumor growth and metastasis. Only recently has the role of neuroimmune cross-talk surfaced as a key contributor to cancer progression. However, little is known about the immunomodulatory role of the neuroglial cells in cancer progression and metastasis and the response to therapy. Schwann cells, the principal glial cells of the peripheral nervous system, are now considered to be important players in the tumor microenvironment. They can directly accelerate malignant cell migration and the formation of metastases. Better understanding of the neuroimmune circuits in the tumor milieu will be instrumental in the development of novel therapeutic approaches for the malignancies known to be associated with inflammation and dysregulated immune responses.

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Section: Neuroimmune Axis In Cancermentioning

confidence: 89%

The Neuroimmune Axis in the Tumor Microenvironment

Shurin

Zlotnikov

et al. 2020

The Journal of Immunology

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“…Of note, CADM3 mutations are associated with type 2FF Charcot–Marie–tooth disease (OMIM #619519), a peripheral neuropathy characterized by early childhood onset, progressive weakness and muscle atrophy 51 . In this context, both Col20a1 and Cadm4 are excellent candidate loci for the design of genetic tools to study how the peripheral nervous system regulates endochondral bone development and regeneration 52 …”

Section: Resultsmentioning

confidence: 99%

“…51 In this context, both Col20a1 and Cadm4 are excellent candidate loci for the design of genetic tools to study how the peripheral nervous system regulates endochondral bone development and regeneration. 52 In the hematopoietic compartment, several of the MC clusters were predicted to interact with HPC, and preferentially with Eo/Bas and ILC-TSP2, with GFP, SFP, AFP and CLFP being the most active (Figure 4a). Representative direct connectors for HPC, ILC-TSP2 and Eo/Bas include App-CD74, Icam1-Itgal and Sell-CD34, respectively (Figure 4b and Supplementary table 6).…”

Section: Interactions Between Endochondral Cell Subsets and Implicati...mentioning

confidence: 99%

The cellular landscape of the endochondral bone during the transition to extrauterine life

Rueda,

Salvador‐Martínez,

Sospedra‐Arrufat

et al. 2024

Immunol Cell Biol

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The cellular complexity of the endochondral bone underlies its essential and pleiotropic roles during organismal life. While the adult bone has received significant attention, we still lack a deep understanding of the perinatal bone cellulome. Here, we have profiled the full composition of the murine endochondral bone at the single‐cell level during the transition from fetal to newborn life and in comparison with the adult tissue, with particular emphasis on the mesenchymal compartment. The perinatal bone contains different fibroblastic clusters with blastema‐like characteristics in organizing and supporting skeletogenesis, angiogenesis and hematopoiesis. Our data also suggest dynamic inter‐ and intra‐compartment interactions, as well as a bone marrow milieu that seems prone to anti‐inflammation, which we hypothesize is necessary to ensure the proper program of lymphopoiesis and the establishment of central and peripheral tolerance in early life. Our study provides an integrative roadmap for the future design of genetic and cellular functional assays to validate cellular interactions and lineage relationships within the perinatal bone.image

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“…Simultaneously, rSCs release more chemokines and neurotrophic factors [ 24 , 48 , 52 ]. In addition to the nerve, new research results show that injury in other tissues can activate the repair program of SCs and promote repair and regeneration [ 53 , 54 ]. Parfejevs et al described a similar phenotypic transition of SCs in the context of skin wound healing, where rSCs could spread from injured nerves to granulation tissue and support non-neural tissue repair [ 55 ].…”

Section: Scs In the “Tumor-nerve Niche”mentioning

confidence: 99%

Schwann Cells in the Tumor Microenvironment: Need More Attention

Sun

Chen

2022

Journal of Oncology

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The tumor microenvironment (TME), which is composed of various cell components and signaling molecules, plays an important role in the occurrence and progression of tumors and has become the central issue of current cancer research. In recent years, as a part of the TME, the peripheral nervous system (PNS) has attracted increasing attention. Moreover, emerging evidence shows that Schwann cells (SCs), which are the most important glial cells in the PNS, are not simply spectators in the TME. In this review article, we focused on the up-to-date research progress on SCs in the TME and introduced our point of view. In detail, we described that under two main tumor-nerve interaction patterns, perineural invasion (PNI) and tumor innervation, SCs were reprogrammed and acted as important participants. We also investigated the newest mechanisms between the interactions of SCs and tumor cells. In addition, SCs can have profound impacts on other cellular components in the TME, such as immune cells and cancer-associated fibroblasts (CAFs), involving immune regulation, tumor-related pain, and nerve remodeling. Overall, these innovative statements can expand the scope of the TME, help fully understand the significant role of SCs in the tumor-nerve-immune axis, and propose enlightenments to innovate antitumor therapeutic methods and future research.

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Schwann cells: an emerging player in tissue regeneration

Cited by 5 publications

References 8 publications

The Neuroimmune Axis in the Tumor Microenvironment

The Neuroimmune Axis in the Tumor Microenvironment

The cellular landscape of the endochondral bone during the transition to extrauterine life

Schwann Cells in the Tumor Microenvironment: Need More Attention

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